Polysaccharide-based nanogels for biomedical applications: A comprehensive review

carbohydrates, drug delivery,

The biomedical, biotech, and food industries all use polysaccharides as vital biomolecules with a variety of applications. Polysaccharides have great potential as biomaterials, and polysaccharide-based nanogels have attracted a lot of attention as carriers for different bioactive agents due to their unique versatile groups, specifically for site-directed or controlled delivery of the payload and, particularly because of their physicochemical properties, biodegradability, and biocompatibility. The 3D polymer network of NG produced by chemical crosslinking or physical self-assembly may be used to incorporate hydrophilic or hydrophobic molecules, including tiny drugs and proteins, genetic material patterns, and even ultrasmall nanoparticles. In this review, the chemistry of specific common polysaccharides and the various methods used to fabricate polysaccharide-based NG is discussed, with an emphasis on their use NG as drug delivery systems.

FOUAD DAMIRI, Dr.Satish Rojekar, Yahya Bachra, Rajender Varma, Dr. Swetha Andra, Satheesh kumar Balu, Dr. Chandrakantsing Pardeshi, Vijaysing Pardeshi, Hitendra Patel, Ana Cláudia Paiva-Santos, Mohammed Berrada, Mónica Cristina García

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Sialic acid-targeted cyclodextrin-based nanoparticles deliver CSF-1R siRNA and reprogram tumour-associated macrophages for immunotherapy of prostate cancer

drug delivery, drug development

Another important paper on cyclodextrin-assisted gene therapy from the GENEGUT consortium leader University College Cork (Caitriona O’Driscoll) now proposing a sialic acid-targeted cyclodextrin-based nanoparticle to specifically deliver CSF-1R siRNA to M2 macrophages. This targeted cyclodextrin-based siRNA drug delivery system provides a potential strategy for prostate cancer immunotherapy.
Monique Mendonça, Jianfeng Guo et al

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Three-in-one: exploration of co-encapsulation of cabazitaxel, bicalutamide and chlorin e6 in new mixed cyclodextrin-crosslinked polymers

drug delivery, ,

Another great paper comes out of the long-term collaboration between our CSO,Milo Malanga and Ilse Manet‘s lab at National Research Council of Italy.
We explored a series of cyclodextrin (CyD) polymers composed either of a single CyD type or a mixture of two CyD types to encapsulate simultaneously different compounds with potential therapeutic interest for multimodal prostate cancer treatment. Thanks to a single inexpensive CyD-based polymer, we produced a three-in-one platform for the future implementation of combined chemotherapy and photodynamic therapy. These achievements are most relevant as nanomedicines are continuously proposed, but their potential for translation to the pharma industry is compromised by their limited potential for industrial upscale.

Elisabetta Pancani, PharmD, Marco Agnes, Arianna Mazza, Alessandro Venturini et al.

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Facile microwave-assisted synthesis of Dialdehyde−β−Cyclodextrin for evaluation of angiogenesis in wound healing

Today's cyclodextrin, ,

today’s #cyclodextrin:
An exponential growth in chronic non-healing wounds worldwide has propelled the dire need for the design of effectual interventions. Of late, dialdehyde polysaccharides have blossomed as novel antimicrobial agents. Yet, such dialdehydes, accomplished by periodate oxidation, are mostly synthesized by the conventional strategy. Microwave-assisted synthesis, as of today, finds greater relevance than conventional methods as it is environmentally more benign. This research contribution focuses on the microwave-initiated rapid synthesis of dialdehyde−β−Cyclodextrin (DA−β−CD) for its efficient use in chronic wound healing. The antibacterial and antibiofilm activities of DA−β−CD were systematically assessed against Staphylococcus epidermidis. The hemocompatible and cytotoxicity were also evaluated. In vivo angiogenic potential was performed in chick embryo. The results suggested that the microwaved product was endowed with improved aqueous solubility and fared better in wound healing than the conventional product.

Debosmita Dash, Purnendu Parhi et al at Ravenshaw University and Odisha University of Technology and Research

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Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

Today's cyclodextrin,

today’s #cyclodextrin:
are peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables the irreversible deactivation of a wide range of T-like phages. The compounds can be used directly inside the environment of the bioreactor, but they are also a safe additive to stocks of antibiotics and expression inducers (such as isopropyl β-d-1-thiogalactopyranoside, i.e., IPTG) that cannot be autoclaved and are a common source of phage infections.
EPFL (École polytechnique fédérale de Lausanne) – Paulo Jacob Silva, Laura Roset Julià, Carla Malinverni, Lixia Wei, Marcin Los, and Francesco Stellacci et al

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Growing impact of sialic acid-containing glycans in future drug discovery

Egyéb kategória

In nature, almost all cells are covered with a complex array of glycan chains namely sialic acids or nuraminic acids, negatively charged nine-carbon sugars, which is considered for their great therapeutic importance since long back. Owing to its presence at the terminal end of the lipid bilayer (commonly known as terminal sugars), the well-defined sialosides or sialoconjugates have served a pivotal role on the cell surfaces, and thus, the sialic acid-containing glycans can modulate and mediate a number of imperative cellular interactions. Understanding the sialo-protein interaction and their roles in vertebrates in regard of normal physiology, pathological variance, and evolution has indeed a noteworthy journey in medicine.
This is a concise overview of the structure, linkages in chemical diversity, and biological significance followed by chemical and enzymatic modification/synthesis of sialic acid containing glycans. More focus is attempted on the recent advances, opportunity, and moreover, growing impact of sialosides and sialoconjugates in future drug discovery and development.
Priyanka Bose, Dr. Manoj Kumar Jaiswal, Vinod Tiwari et al – Banaras Hindu University

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Formulation and stability study of an oral paediatric phenobarbital 1% solution containing hydroxypropyl-β-cyclodextrins

Today's cyclodextrin

Today’s cyclodextrin:
is a pediatric application. Phenobarbital is a barbiturate used to treat focal and generalized epilepsy. Since the end of marketing of the oral solution KANEURON in 2017, phenobarbital tablets remain the only available dosage form. Therefore, developing an oral phenobarbital solution for pediatric use is essential to fulfilling clinical needs. A new formulation of phenobarbital with hydroxypropyl-β-cyclodextrins (HPBCD) was developed, and the physicochemical stability of the solution was evaluated.
Louise Parrenne, Zoé Ribier et al – Greater Paris University Hospitals – AP-HP

See the full article here: Formulation and stability study of an oral paediatric phenobarbital 1% solution containing hydroxypropyl-β-cyclodextrins