Long-term administration of intravenous Trappsol® Cyclo™ (HP-β-CD) results in clinical benefits and stabilization or slowing of disease progression in patients with Niemann-Pick disease type C1: Results of an international 48-week Phase I/II trial

carbohydrates, drug development, ,

Long-term administration of intravenous Trappsol® Cyclo™ (HP-β-CD) results in clinical benefits and stabilization or slowing of disease progression in patients with Niemann-Pick disease type C1: Results of an international 48-week Phase I/II trial.
Niemann-Pick disease type C (NPC) is a rare, fatal, pan-ethnic, autosomal recessive lysosomal storage disease characterized by progressive major organ failure and neurodegeneration. Preclinical studies confirmed the critical role of systemically administered hydroxypropyl-β-cyclodextrin (HP-β-CD; Trappsol® Cyclo™) in cholesterol metabolism and homeostasis in peripheral tissues of the body, including the liver, and in the central nervous system (CNS). Herein, the pharmacokinetics (PK), safety, and efficacy of HP-β-CD and biomarkers of NPC were assessed in pediatric and adult patients with NPC1.
Cyclo Therapeutics, Inc. –  Caroline Hastings, Sharon Hrynkow et al

Long-term administration of intravenous Trappsol® Cyclo™ (HP-β-CD) results in clinical benefits and stabilization or slowing of disease progression in patients with Niemann-Pick disease type C1: Results of an international 48-week Phase I/II trial – ScienceDirect

Screening of sugars and cyclodextrins as carriers in montelukast dry powder inhalers processed by spray freeze drying

Today's cyclodextrin,

Today’s cyclodextrin:
This study aimed to develop a site targeting montelukast sodium (MTK) microparticles as a respiratory drug delivery system using the spray freeze-drying process. A range of sugars and cyclodextrins were screened as carriers in order to find compatible excipients for the preparation of dry powder inhalers.
Powders containing CDs mostly showed proper aerodynamic behavior, especially in formulations containing alfa-cyclodextrin (A-CD), beta-cyclodextrin (β-CD), and highly branched cyclic dextrin (HBCD). Overall, data indicated that the CDs were excellent excipients for use with MTK for respiratory drug delivery.

Screening of sugars and cyclodextrins as carriers in montelukast dry powder inhalers processed by spray freeze drying


Cyclodextrin-based anti-microbial therapy

carbohydrates, drug development, ,

Cyclodextrin-based antimicrobial/antiviral therapy discovered at the University of Southern California
A rapidly deployable nanoscale biodegradable system using hydroxypropyl beta cyclodextrin-based combination product is presented as an agnostic barrier blocking pathogenic microbes that has localized on the mucocutaneous lining of the conjunctiva, mouth and nose, lung, or gastrointestinal tract. The cyclodextrin may bind the viral particles and/or disrupt viral entry mechanisms by removing cholesterol from viral particles to reduce infectivity. Cyclodextrins also may facilitate the removal of the viral cholesterol molecules, thus rendering them less viable.
Stan Louie; Gianluca Lazzi; Jean-Marie Bouteiller

You can read the patent on Espacenet!

A stable composition comprising honey and a cannabinoid

Today's cyclodextrin,

Today’s cyclodextrin:
It is a unique combination of honey and cannabinoids. In these compositions, CDs are used as emulsifiers and stabilizers so that the rate of degradation of the active components in honey, including methylglyoxal and dihydroxyacetone, is reduced. The composition is also physically stabilized such that the rate of separation of the cannabinoid is reduced and the homogeneity of the composition is maintained over time.

See the patent on Espacenet!

Aggregation Behavior of Cyclodextrin-Based [3]Rotaxanes

drug delivery, Today's cyclodextrin,

Today’s #cyclodextrin:
I have shared several papers and patents already on the fascinating and widespread applications of rotaxanes, from cosmetics through drug delivery to advanced materials.
In this paper Yosuke Akae and Patrick Theato report on an important practical aspect of their use, particularly on the aggregation of cyclodextrin (CD)-based [3]rotaxane, which forms a hexagonal packing type aggregation derived from hydrogen bond formation among CD units in a similar manner to polyrotaxane species. This aggregation could be controlled by solvent type on dispersion treatment, axle end structures, and modification of CD.

To the full article, please follow this link!

Whole-body cellular mapping in mouse using standard IgG antibodies

carbohydrates,

Fascinating new method, wildDISCO, uses 2,6-dimethyl-β-cyclodextrin to overcome the limitations of conventional whole-body imaging methods.

This technology enables the uniform staining of whole bodies with conventional IgG antibodies and reveals cellular and structural maps across the entire mouse body. This has allowed us to map diverse biological systems, including peripheral nerve atlases and the complete lymphatic system, and make novel biological findings. We studied tertiary lymphoid structures (TLS) in the whole mouse body along with cancer metastasis, providing insights into their therapeutic potentials.

The wildDISCO method facilitates the visualization of endogenous proteins in a whole body without a transgenic reporter. Its compatibility with over 30 commercial antibodies marks a breakthrough in biomedical applications and research at the whole mouse level.
Rami Al-Maskari, Izabela Horvath, Marie Piraud, Johannes C. Paetzold, Jennifer Modamio, Farida Hellal & Ali Ertürk et al.

See the full article on nature.com!


Developed an Indocyanine / β-cyclodextrin conjugate for ureter visualization

Today's cyclodextrin

Today’s cyclodextrin:
It is in the field of imaging. Mie University and Nagoya University has jointly developed an Indocyanine / β-cyclodextrin conjugate suitable for ureter visualization in patients undergoing laparoscopic/minimally invasive colorectal surgery. 
Astellas Pharma has acquired exclusive development and marketing rights worldwide (the designation of the compound is ASP5354). A recent clinical trial investigated the safety, tolerability and the pharmacokinetics of ASP5354 in participants undergoing laparoscopic/minimally invasive surgery.
ASP5354 fluoresces upon excitation with a particular wavelength of near-infrared light. When administered intravenously, ASP5354 is primarily and rapidly excreted by the kidneys and provides the surgeon with visualization of the ureter(s) during surgery through the use of a near-infrared fluorescence (NIR-F) medical device.

Please follow these links to read the corresponding article!

A Study for Ureter Visualization, Using ASP5354 in Subjects Undergoing Laparoscopic/Minimally Invasive Colorectal Surgery

Ready vascular permeability of a near‑infrared fluorescent agent ASP5354 for intraoperative ureteral identification enables imaging of carcinoma tissues.

Northwestern University and CarboHyde in arms against water contamination

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It’s our pleasure to share that Will Dichtel’s lab at Northwestern University and CarboHyde just entered into a long-term research collaboration aiming to explore better Dr. Dichtel’s current research on the potential use of cyclodextrins as PFAS removers from drinking water.

Dr. Dichtel has been successfully working on various strategies to remove pollutants from drinking and wastewater. Now his expertise and concept will be supported by the cyclodextrin chemistry know-how of CarboHyde to create even more potent tools in this challenging application.

https://www.linkedin.com/posts/carbohyde_cyclodextrin-pfas-waterpurification-activity-7087002686151176193-6wJp?utm_source=share&utm_medium=member_desktop

Supramolecular preparation of retinol and derivatives thereof and preparation method therefor

Today's cyclodextrin

Today’s cyclodextrin:
is a case study from the cosmetic industry. Here, CDs are mainly used to stabilize components, as emulsifiers, and of course, as solubilizers. Proya Cosmetics proposes the supramolecular preparation of retinol and derivatives thereof having the advantages such as good stability, high solubility, low irritation, and good anti-wrinkle effect.

The full patent is available on Espacenet!