Treatment of cancer

This patent on CRLX-101, an experimental approach using camptothecin (CPT) to cancer chemotherapy, reminded us of a wonderful idea from Mark Davis (Caltech). In CRLX101, CPT is linked covalently through a glycine link to the linear copolymer CDP, which in turn consists of alternating subunits of beta-cyclodextrin and polyethylene glycol (PEG). The CRLX101 nanoparticle is water-soluble. After intravenous injection, active CPT is slowly released as the linkage is hydrolyzed. The size of the nanoparticle (20-50 nm in diameter) facilitates its extravasation in the more leaky vessels of tumors via the enhanced permeability and retention effect. As a result, the anticancer drug is enhanced and retained in the tumor tissue.
The new patent from Ellipses Pharma proposes novel applications dominantly in rectal cancer.
Amato GiacciaHanna SanoffJoel Tepper

Hyaluronan-Cyclodextrin Conjugates as Doxorubicin Delivery Systems

We love both chemistry and carbohydrates. So when people publish about conjugating carbohydrates with carbohydrates and their pharma applications, our hearts are full of inspiration and passion.
Check out how researchers from Università di Catania and Ospedale Policlinico San Martino propose using Hyaluronan-Cyclodextrin Conjugates as drug delivery tools!
Noemi BognanniLuana La PianaSimone Stranorosaria gangemiMaria Teresa CambriaGraziella Vecchio et al

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A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death

A fascinating novel concept of cancer research using lectibodies, a bispecific construct composed of a lectin linked to an antibody fragment. This approach aims to redirect the immune system into fighting cancer by targeting altered glycans at the surface of malignant cells.
The University of Freiburgacib GmbH – Francesca RosatoRajeev P.Jana TomischAna Valeria Meléndez MayorgaDajana Kolanovic, Olga Makshakova, Birgit Wiltschi, Winfried Römer 

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Palleon Pharmaceuticals announces issuance of a U.S. Patent for the use of antibody sialidase conjugates

We are always thrilled to see companies adjancing drugs in the field of glycochemistry, just as Palleon Pharmaceuticals. who recently announced patenting engineered human sialidase enzymes that restore antitumor immunity by degrading immunosuppressive sialoglycans on tumors and across immune cell types

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