Treatment of cancer

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This patent on CRLX-101, an experimental approach using camptothecin (CPT) to cancer chemotherapy, reminded us of a wonderful idea from Mark Davis (Caltech). In CRLX101, CPT is linked covalently through a glycine link to the linear copolymer CDP, which in turn consists of alternating subunits of beta-cyclodextrin and polyethylene glycol (PEG). The CRLX101 nanoparticle is water-soluble. After intravenous injection, active CPT is slowly released as the linkage is hydrolyzed. The size of the nanoparticle (20-50 nm in diameter) facilitates its extravasation in the more leaky vessels of tumors via the enhanced permeability and retention effect. As a result, the anticancer drug is enhanced and retained in the tumor tissue.
The new patent from Ellipses Pharma proposes novel applications dominantly in rectal cancer.
Amato Giaccia, Hanna Sanoff, Joel Tepper

Hyaluronan-Cyclodextrin Conjugates as Doxorubicin Delivery Systems

carbohydrates,

We love both chemistry and carbohydrates. So when people publish about conjugating carbohydrates with carbohydrates and their pharma applications, our hearts are full of inspiration and passion.
Check out how researchers from Università di Catania and Ospedale Policlinico San Martino propose using Hyaluronan-Cyclodextrin Conjugates as drug delivery tools!
Noemi Bognanni, Luana La Piana, Simone Strano, rosaria gangemi, Maria Teresa Cambria, Graziella Vecchio et al

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A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death

carbohydrates

A fascinating novel concept of cancer research using lectibodies, a bispecific construct composed of a lectin linked to an antibody fragment. This approach aims to redirect the immune system into fighting cancer by targeting altered glycans at the surface of malignant cells.
The University of Freiburg, acib GmbH – Francesca Rosato, Rajeev P., Jana Tomisch, Ana Valeria Meléndez Mayorga, Dajana Kolanovic, Olga Makshakova, Birgit Wiltschi, Winfried Römer 

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Palleon Pharmaceuticals announces issuance of a U.S. Patent for the use of antibody sialidase conjugates

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We are always thrilled to see companies adjancing drugs in the field of glycochemistry, just as Palleon Pharmaceuticals. who recently announced patenting engineered human sialidase enzymes that restore antitumor immunity by degrading immunosuppressive sialoglycans on tumors and across immune cell types

Press releases

The synthesis of hyaluronic acid-related oligosaccharides and elucidation of their antiangiogenic activity

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Hyaluronic acid-related oligosaccharides were evaluated as potential antiangiogenic agents by N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences – Nadezhda Ustyuzhanina Nikolay Nifantiev

Link to the full article on ScienceDirect

DOI: https://doi.org/10.1016/j.carres.2022.108701Get rights and content

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