In the past weeks, we have had the pleasure of welcoming Ilse Manet, the leader of the Bicyclos consortium, to our lab and city. We discussed the progress of the staff exchange program, the science we are doing—results obtained, experiments planned—and the fine details of the workshop we organized together in September in Budapest.
Today’s cyclodextrin post sheds light on the fascinating ability of cyclodextrins to complex not only solids and oils, but also gases!
Researchers Todor Dudev and Tony Spassov from Sofia University explore the intimate mechanism of β-cyclodextrin/gas complex formation and answer intriguing questions.
They investigate how the polarity and size of the guest molecule influence complexation thermodynamics, and which encapsulation process by the host macrocycle is more advantageous. They also examine the major factors governing the formation of the complex between β-cyclodextrin and gaseous substances. The research emphasizes the special role that the cluster of water molecules inside the host’s internal cavity plays in the encapsulation process.
If you would like to learn more about such solutions, please visit: www.carbohydesolutions.com – Carbohyde
Fresh from the oven, a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.
Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.
Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.
Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.
Insight Heart is a 3D interactive app that offers a comprehensive and immersive journey into the human heart. It features high-resolution visuals, real-time insights, and interactive elements, making medical education engaging, accessible and enjoyable for students, physicians, and patients anytime and anywhere.
Its key features include a spatial computing experience, multi-user sessions, filter system exploration, and condition visualizations, which allow for remote and efficient collaboration, in-depth understanding of the heart’s complex structures, and an immersive experience of heart conditions.
This provides a new level of understanding and immersion in medical education.
INSIGHT HEART on Apple Vision Pro (youtube.com)
Its our pleasure to announce our most recent paper on
Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy
resulting from a collaboration with Semmelweis University and Aalborg University.
Recognizing that the distribution of substituents significantly influences the complexation ability and overall activity of the derivative, primarily by altering cavity dimensions, we present a straightforward and non-destructive method based on liquid state NMR spectroscopy to analyze the positions of the hydroxypropyl sidechains. This method relies on a single set of routine experiments to establish quantitative assignment and it provides a simple yet effective tool to disclose the substitution pattern of this complex material, utilizing easily accessible (400 MHz NMR) instrumentation.
Szabolcs Béni, Eszter Kalydi, Thorbjørn Terndrup Nielsen, Reinhard Wimmer, Milo Malanga PhD
Today’s cyclodextrin is a unique practical application by CYCLADEX INC that many of you may not know: the recovery of precious metals such as gold, silver, platinum, palladium, and rare earths from precious metal-bearing materials.
Cycladex has developed a series of technologies for the isolation of important metals, including gold, silver, and, its newest discovery, a process for lithium. The Technology has been scaled up in our demonstration plant in the US, and the results show significantly lower costs with environmentally friendly chemicals and excellent yields.
In this setup, cyclodextrins are added to the alkali metal/metal bromide solution to precipitate a metal cyclodextrin complex.
Espacenet – RECOVERY OF PRECIOUS AND RARE EARTH METALS USING CYCLODEXTRIN
