Our CEO, Tamas Sohajda, presented at CPhI North America

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Here are a few words from Tamás about the conference:

A few weeks ago at CPHI North America, I had the pleasure of helping the audience peek into the future of cyclodextrins by showcasing some of the applications we are working on at CarboHyde such as:
– therapeutic cyclodextrins and their development
– using cyclodextrins in vaccines
– using cyclodextrins for gene delivery

I had never spoken at CPHI before, yet it was a fascinating experience, mainly due to James Reidy’s fantastic support.

Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights

drug delivery, Today's cyclodextrin, ,

Today’s cyclodextrin is about the stabilization effect of CDs on proteins, yet from a different angle.

I shared a lot earlier about the potential of CDs replacing surface active agents, yet how about combining them?

This study from Roquette led by Rajeev Gokhale and Vinod T. investigates the collaborative impact of combining polysorbates and HPβCD as excipients in protein formulations. The introduction of HPβCD in formulations showed it considerably reduced aggregation in two model proteins, bevacizumab and ipilimumab, following exposure to various stress conditions. The diffusion interaction parameter revealed a reduction in protein-protein interactions by HPβCD.

The study suggests that combining these excipients can improve mAb stability in formulations, offering an alternative for the biopharmaceutical industry.

Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights – ScienceDirect

mAb, monoclonal antibodies, carbohyde

CarboHyde – Cyclodextrin live Q&A

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Join us for an exclusive LinkedIn Live event as we dive into the intriguing world of cyclodextrins! This dynamic Q&A session features industry experts, researchers, and enthusiasts exploring the diverse applications and cutting-edge advancements in cyclodextrin science.

📅 Date & Time: June 5, 2024, 16:00 CET

📍 Location: LinkedIn Live – Event Link

What to Expect:

  • Expert Insights: Learn about cyclodextrins and their diverse applications.
  • Interactive Q&A: Ask your questions and get real-time answers from experts.
  • Networking: Connect with professionals and researchers in the field.

How to Participate:

  1. Follow our LinkedIn page for updates.
  2. Set a reminder for the event.
  3. Prepare your questions for the Q&A session.

Who Should Attend:

  • Researchers, scientists, and professionals in relevant industries.
  • Students and academics interested in cyclodextrin advancements.

Don’t miss this chance to engage with experts and enthusiasts in cyclodextrin science!

Join us and ask your questions directly to our CEO, Tamas Sohajda.

Register and learn more here: Event Link

Cluster Dextrin™

Today's cyclodextrin

Cluster Dextrin™, also called Highly Branched Cyclic Dextrin (HBCD) is a complex carbohydrate that is said to have several potential benefits for athletes and active individuals. It is manufactured from corn starch utilizing enzymatic reactions. Cluster dextrin provides a steady release of energy. Unlike the bonds in maltodextrin, which all break down at once, the bonds holding cluster dextrin together take more time to ‘unwrap’, and this results in your body being ‘drip fed’ with carbs.

Unfortunately, as seen below, it is also often referred to as cyclodextrin, which as we know is a different molecule, although it is also manufactured from corn starch utilizing enzymatic reactions, moreover, it is a complex carbohydrate that is said to have several potential benefits for athletes and active individuals.

A novel process for the preparation of amorphous solid dispersion of 1-{3-[3-(4-chlorophenyl) propoxy] propyl} piperidine, hydrochloride with hydroxypropyl beta-cyclodextrin (HPBCD)

carbohydrates

Amorphous solid dispersions (ASDs) are frequently employed to improve the bioavailability of poorly soluble molecules by enhancing the rate and extent of dissolution in the drug product development process. These systems comprise an amorphous active pharmaceutical ingredient stabilized by a polymer matrix to provide enhanced stability.

Amorphous products, particularly ASDs, are currently the most emerging area in the pharmaceutical field. This strategic approach presents a huge impact and advantageous features concerning the overall improvement of drug product performance in clinical settings, which ultimately leads to drug product approval by leading regulatory agencies into the market.

In this patent by Biophore India Pharmaceuticals Pvt. Ltd. the combination of cyclodextrin and amorphous solid dispersion is discussed.

To learn more about such formulation strategies, check out our website: www.carbohydesolutions.com – Carbohyde

Espacenet – A NOVEL PROCESS FOR THE PREPARATION OF AMORPHOUS SOLID DISPERSION OF 1-{3-[3-(4-CHLOROPHENYL) PROPOXY] PROPYL} PIPERIDINE, HYDROCHLORIDE WITH HYDROXYPROPYL BETA-CYCLODEXTRIN (HPβCD)

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers

Egyéb kategória

Fresh from the oven, is a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.

Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.

Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers | ACS Medicinal Chemistry Letters

Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.

Bicyclos project runs at full speed

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In the past weeks, we have had the pleasure of welcoming Ilse Manet, the leader of the Bicyclos consortium, to our lab and city. We discussed the progress of the staff exchange program, the science we are doing—results obtained, experiments planned—and the fine details of the workshop we organized together in September in Budapest.

Inclusion Complexes between β-Cyclodextrin and Gaseous Substances—N2O, CO2, HCN, NO2, SO2, CH4 and CH3CH2CH3: Role of the Host’s Cavity Hydration

Today's cyclodextrin,

Today’s cyclodextrin post sheds light on the fascinating ability of cyclodextrins to complex not only solids and oils, but also gases!

Researchers Todor Dudev and Tony Spassov from Sofia University explore the intimate mechanism of β-cyclodextrin/gas complex formation and answer intriguing questions.

They investigate how the polarity and size of the guest molecule influence complexation thermodynamics, and which encapsulation process by the host macrocycle is more advantageous. They also examine the major factors governing the formation of the complex between β-cyclodextrin and gaseous substances. The research emphasizes the special role that the cluster of water molecules inside the host’s internal cavity plays in the encapsulation process.

Inorganics | Free Full-Text | Inclusion Complexes between β-Cyclodextrin and Gaseous Substances—N2O, CO2, HCN, NO2, SO2, CH4 and CH3CH2CH3: Role of the Host’s Cavity Hydration (mdpi.com)

If you would like to learn more about such solutions, please visit: www.carbohydesolutions.com – Carbohyde

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers

Egyéb kategória

Fresh from the oven, a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.

Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.

Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.

Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers | ACS Medicinal Chemistry Letters