Dow proposes a method to make a silicon glycan is provided. The silicon glycan comprises a glycoside moiety, independently selected organosilicon moieties, and linking moieties joining the organosilicon moieties to the glycoside moiety.
Marc-André Courtemanche; Emmett Partain
See the full patent here: A method for preparing a silicon glycan
Changes in the glycosylation process appear early in carcinogenesis and evolve with the growth and spread of cancer. The correlation of the characteristic glycosylation signature with the tumor stage and the appropriate therapy choice is important in translational medicine. Oncologists also pay attention to extracellular vesicles as reservoirs of new cancer glycomarkers that can be potent for cancer diagnosis/prognosis. In this review, Karolina Grzesik, Marcelina Janik, Dorota Hoja-Łukowicz from Jagiellonian University collect glycomarkers used in oncology and show their new glycoforms of improved clinical relevance, summarize current knowledge on the biological functions of glycoepitopes in cancer-derived extracellular vesicles and their potential use in clinical practice. Is glycomics a future of cancer diagnosis? It may be but in combination with other omics analyses than alone.
See the full review here: The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment
Fascinating discovery from BASF on increasing space-time-yield, carbon-conversion-efficiency, and carbon substrate flexibility in the production of fine chemicals. They found a positive effect of increased cAMP levels and/or manipulating the PTS system on the above characteristics achieved by de-regulating adenylate cyclase cyaa by deleting the C-terminal regulatory region leading to increased cAMP levels or deleting the Crr protein activity (carbohydrate repression resistance) which regulates the carbohydrate utilization system. Both lead to increased 2-fucosyllactoe and 6-sialyllactose production (human milk oligosaccharides) and increase carbohydrate usage.
Hartwig Schroeder; Peter Ödman]; Georg Wandrey; Christian Dietzsch; Dominik Satory; Matthew Blankschien; Jens Plassmeier et al.
See the full patent on Espacenet
Interesting conceptual comparison of Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives by László Jicsinszky, Giancarlo Cravotto, et al. from the University of Turin.
See the full article in Molecules.
A fascinating journey in the world of novel glycopeptide antibiotics with stops such as overcoming resistance in Gram-positive and Gram-negative bacteria and combined antiviral and antibiotic effects guided by Anikó Borbás and her group at University of Debrecen supported by several international KOLs in the field (Ilona Bakai-Bereczki, Ferenc Fenyvesi, Pal Herczegh, Eszter Ostorhazi, Henrietta Papp, Batta Gyula, Ana Mitrović, Janko Kos, István Hajdu, Dávid Bajusz, György Keseru, et al)
See the corresponding articles on nature.com:
Fascinating joint invention by Università degli Studi di Firenze and Florida International University – Robert Sackstein MD,PhD, Barbara Richichi, and Kyle Martin.
The specific glycomimetic fucosyltransferase inhibitors created are proposed for treatment of a variety of diseases, like acute inflammatory disease, chronic inflammatory disease, diabetes, cystic fibrosis, or a cancer via a modification of fucosylated cell surface glycoconjugates.
Science masterpiece by Università degli Studi di Milano-Bicocca – Laura Russo, who presents the development of a 3D printed colorectal cancer model discovering that hyaluronic acid and gelatin glycosylation influences the construct morphology, and protein profiles of tumoroid cells
Mindblowing study!
See the full article here
Griffith University (Oren Cooper, Dechao Chen, Thomas Haselhorst, Joseph Tiralongo et al) and University of Bremen released common findings on creating multivalent siglec probes through the decoration of α(2,6)-sialyllactose ligands on inherently fluorescent carbon dots capable of generating a significant cytotoxic effect on Burkitt’s Lymphoma (BL) Daudi B cells.
Using sugars in a prodrug concept is a fascinating idea as these compounds can bring so much to the table like improve stability, PK, or help in targeting. In this patent from Heidelberg University oligosaccharide conjugated prostate-specific membrane antigens are described where the bonds are cleaved by amylase in the body.
Oral, topical, and agrochemical uses of nanochitin presented by Shinsuke Ifuku from Tottori University.
