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Prostate-specific membrane antigen (PSMA) ligands comprising an amylase cleavable linker

Nov 10, 2022Tamas Sohajdacarbohydrates, drug discoveryadc, glycotime, targeted therapy

Using sugars in a prodrug concept is a fascinating idea as these compounds can bring so much to the table like improve stability, PK, or help in targeting. In this patent from Heidelberg University oligosaccharide conjugated prostate-specific membrane antigens are described where the bonds are cleaved by amylase in the body.

See the patent on espacenet

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