Composition for the prevention of infection by SARS-COV-2

Today's cyclodextrin, ,

Today’s cyclodextrin is interesting both from the application and the formulation point of view. Mouth rinses and mouthwashes are not so common with CDs, yet certainly they are gainly space in dental hygiene. Yet in this invention from MAGI Euregio, not only the comlex forming, but also antiviral (specifically anti covid) properties are also exploited.

The composition includes α-cyclodextrin and hydroxytyrosol and is effective (even proven clinically) in preventing SARS-CoV-2 infection, whereas also effective in contrasting halitosis in subjects that wear a mask for a prolonged period.

Espacenet – Composition for the prevention of infection by SARS-COV-2


Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States

Today's cyclodextrin, ,

Today’s cyclodextrin is an essential paper on understanding differences in internalization and cellular location of various polyrotaxanes by Hokkaido University, Japan Science and Technology Agency (JST) and Tokyo Medical and Dental University

Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of defective proteins and the formation of abnormal organelles. Methylated β-cyclodextrins-threaded polyrotaxane (Me-PRX), a supramolecular structured polymer, induces autophagy by interacting with the endoplasmic reticulum. The same level of autophagy induction was achieved at one-twentieth the dosage for the mitochondria-targeted nanocarrier (Me-PRX) compared to the naked Me-PRX. The quantitative evaluation of the intracellular organelle localization of both naked Me-PRX and the MITO-Porter (Me-PRX) are reported here. Mitochondria, endoplasmic reticulum and lysosomes were selected as target organelles because they would be involved in autophagy induction. In addition, organelle injury and cell viability assays were performed. The results showed that the naked Me-PRX and the MITO-Porter (Me-PRX) were localized in different intracellular organelles, and organelle injury was different, depending on the route of administration, indicating that different organelles contribute to autophagy induction. These findings indicate that the organelle to which the autophagy-inducing molecules are delivered plays an important role in the level of induction of autophagy.

Biomolecules | Free Full-Text | Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States (mdpi.com)

Preparation process of low-irritation hair dye with color protection function

Today's cyclodextrin, , ,

Today’s cyclodextrin:
With the party mood of the weekend approaching, let’s see an example of using CDs as hair dye components. The invention provides a low-irritation hair dye with a color protection function. As claimed, the hair dye can greatly reduce scalp irritation, reduce scalp stabbing pain and burning feelings caused by hair dyeing of consumers in the past, reduce direct contact between irritant substances and scalp, and greatly reduce scalp irritation.

Espacenet – Preparation process of low-irritation hair dye with color protection function

Cyclodextrins permeabilize DPPC liposome membranes: a focus on cholesterol content, cyclodextrin type, and concentration

drug delivery, Today's cyclodextrin,

Today’s cyclodextrin is a smart and very practical study, highlighting how different cyclodextrins added to a liposomal formulation could influence the release of the active load.

The results demonstrated that the CDs effect on the membrane depends on the CD type, CD concentration, and membrane cholesterol content. The investigated CDs exhibited an instantaneous permeabilizing effect promoting vesicle leakage of API from the various membranes; this effect increased with CDs concentration. Among the studied CDs, α-CD, β-CD, and RAMEB were the most permeabilizing CDs on the different membranes.

Ghenwa Nasr, Helene Greige, Sophie Fourmentin, Abdelhamid ELAISSARI, Nathalie Khreich

BJOC – Cyclodextrins permeabilize DPPC liposome membranes: a focus on cholesterol content, cyclodextrin type, and concentration (beilstein-journals.org)

Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors

Today's cyclodextrin,

today’s cyclodextrin: Cyclodextrin-supported sensors on the way!

While hydrogels enable a variety of applications in wearable sensors and electronic skins, they are susceptible to fatigue fracture during cyclic deformations owing to their inefficient fatigue resistance. Herein, acrylated β-cyclodextrin with bile acid is self-assembled into a polymerizable pseudorotaxane via precise host-guest recognition, which is photopolymerized with acrylamide to obtain conductive polymerizable rotaxane hydrogels (PR-Gel). The topological networks of PR-Gel enable all desirable properties in this system due to the large conformational freedom of the mobile junctions, including the excellent stretchability along with superior fatigue resistance. PR-Gel based strain sensor can sensitively detect and distinguish large body motions and subtle muscle movements. The three-dimensional printing fabricated sensors of PR-Gel exhibit high resolution and altitude complexity, and real-time human electrocardiogram signals are detected with high repeating stability. PR-Gel can self-heal in air, and has highly repeatable adhesion to human skin, demonstrating its great potential in wearable sensors.

Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors | Nature Communications

HumanLectome, an update of UniLectin for the annotation and prediction of human lectins

carbohydrates

The UniLectin portal was designed in 2019 with the goal of centralising curated and predicted data on carbohydrate-binding proteins known as lectins. UniLectin is also intended as a support for the study of lectomes (full lectin set) of organisms or tissues. 
Check out the most recent update by Anne Imberty, Frederique Lisacek and colleagues:

HumanLectome, an update of UniLectin for the annotation and prediction of human lectins | Nucleic Acids Research | Oxford Academic (oup.com)

Cyclodextrins as molecular carriers for biopesticide

Today's cyclodextrin,

today’s cyclodextrin:
Is a nice reivew by Sophie Fourmentin et al on applicatations for biopesticides.

The application of biopesticides can be challenging because they are generally insoluble in aqueous phases, highly volatile and unstable. One strategy to promote their use is their encapsulation into natural hosts, cyclodextrins. Encapsulation in cyclodextrins would offer many advantages such as increased solubility, lower release rates and protection against chemical and physical degradation. The paper discusses preharvest treatment and the different stages of the postharvest handling such as storage, distribution, packaging and marketing.

Cyclodextrins as molecular carriers for biopesticides: a review | SpringerLink

Concrete water reducer and preparation method

Today's cyclodextrin,

Today’s cyclodextrin:
Did you know that CDs can be used even in the construction industry? There are many applications, one is reducing water in concrete.
Here, a modified beta-cyclodextrin polycarboxylic acid water reducing agent, an anti-mildew antibacterial agent, sodium lignin sulfonate, sodium dodecyl benzene sulfonate, a polyether defoaming agent, sodium tripolyphosphate, triisopropanolamine, sodium nitrite, ethylene glycol and water to obtain the concrete water reducing agent. The concrete water reducer prepared is excellent in slump retaining performance and water reducing performance, and good in storage stability.

Espacenet – search results


Cyclodextrin inclusion complexes improving antibacterial drug profiles: an update systematic review

Today's cyclodextrin,

Today’s cyclodextrin:

Improving antibacterial drugs’ physicochemical characteristics and biological activities has been in the focus of CD research for a long time. This extensive review by deals with this topic showing the biological results rvealing the antibacterial effect of the inclusion complexes was extensively improved. Cyclodextrins can enhance the therapeutic effects of antibiotics already existing on the market, natural products and synthetic molecules. Overall, CDs as drug-delivery vehicles have been shown to improve antibiotics solubility, stability, and bioavailability, leading to enhanced antibacterial activity.

Cyclodextrin inclusion complexes improving antibacterial drug profiles: an update systematic review | Future Microbiology (futuremedicine.com)