carbohydrates - CarboHyde

Cyclodextrin based artificial enzymes

Mar 21, 2025adminToday's cyclodextrinAI, cyclodextrin

Using cyclodextrins (CDs) as scaffolds for artificial enzymes has emerged as a promising strategy for improving catalytic processes.

CDs are still widely used in the design of artificial enzymes and in understanding the enzymatic reaction mechanisms, especially in applications that require the modification of substrate solubility or the stabilization of reaction intermediates.

This review summarizes the CD-based artificial enzyme development, discusses key challenges and limitations of syntheses, and explores potential strategies to improve their catalytic activity.

Great paper from László Jicsinszky, Katia Martina, Luisa Boffa, Giancarlo Cravotto

Webinar at the request of a partner

Mar 18, 2025Tamas Sohajdacarbohydrates, education

I had the pleasure to deliver a short online seminar to an audience of experts at NIPER S.A.S. NAGAR.

I was flattered by the invitation and the organization.

Want to do something similar? I would love to, just let me know.

Extended and enhanced release with cyclodextrin

Mar 17, 2025Tamas Sohajdacarbohydrates, educationcarbohyde, cyclodextrin, formulation development

One of the biggest problems to overcome with cyclodextrins?
Sustained release.

In this deck we show how we achieve this at CarboHyde, leveraging the synergistic advantages of cyclodextrin and other drug delivery technologies.

Do you have an active on the shelf to try this tool with?

Extended and enhanced release with cyclodextrins Download

Stabilized Nucleic Acid Processing for Enhanced Amplification

Mar 12, 2025Tamas SohajdaToday's cyclodextrincyclodextrin, dna, nucleic acid

today’s cyclodextrin:
I love this invention from Biomeme, Inc. for processing a target nucleic acid sequence.

The inventors – Jonathan H. & Stephen Judice – use cyclodextrin to stabilize an enzyme and nucleic acids.
CDs can also shorten a cycle threshold value or a time to result value in the nucleic acid amplification and lower a detection limit.

Read the patent here: WO2025049920 METHODS AND COMPOSITIONS FOR SAMPLE PROCESSING

CarboHyde Cyclodextrin Masterclass IV

Mar 12, 2025adminToday's cyclodextrin, newscarbohyde, cyclodextrin, event

What to Expect?
Explore the evolving landscape of cyclodextrin-based drug delivery, from established uses to groundbreaking innovations. Our expert speaker will dissect key advancements, addressing both challenges and transformative opportunities that enhance therapeutic efficacy.

Key Focus Areas:
Monoclonal Antibodies
Gene Therapy
Vaccines
Biotechnology

You can register here: Cyclodextrin Masterclass IV – CarboHyde

New cyclodextrin patent for agricultural application

Feb 28, 2025Tamas SohajdaToday's cyclodextrin

Today’s cyclodextrin is my next cyclodextrin patent.

I have been advocating for improved solutions for agriculture formulations for a long time.

Cyclodextrins can help improve the biological activity and uptake of pesticides and insecticides, improve their penetration, reduce their applied dose (and burden on the environment) and even achieve controlled release of these agents.

US20250057161 USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM

This is what our patent with ADAMA Ltd. is about.
Shimon Amselem, Lital Koren, Zoltán Fülöp, István Puskás

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential

Feb 26, 2025Tamas SohajdaToday's cyclodextrincyclodextrin

Hungarian cyclodextrin science flourishes!

This paper by Horváti Kata & Chiara Bellini et al is about formulating lipopeptides.

Formulation with the randomly methylated α-cyclodextrin (RAMEA) and the sulfobutylether-β-cyclodextrin (SBECD) has resulted in the production of ultralow-sized molecular dispersion systems and reduced lipopeptide toxicity without compromising its antimicrobial activity.

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential – Bellini – Aggregate – Wiley Online Library

Inhibitor inclusion complex nitrogen fertilizer compositions

Feb 25, 2025Tamas SohajdaToday's cyclodextrinagriculture

Today’s cyclodextrin is about an agricultural application from SABIC.

In this invention, Sabic uses cyclodextrin for fertilizing via encapsulating urease inhibitors in a solidified nitrogen fertilizer melt.

The inhibitor (e.g., a nitrification and/or urease inhibitor), when complexed with the cyclodextrin, can be thermally stable at temperatures (e.g., 140 °C or more) exceeding the melt temperature of the nitrogen fertilizer. This can be advantageous in that the complexes can be contacted with and dispersed throughout molten nitrogen fertilizer with reduced, minimal, or no degradation of the inhibitors.

WO2025032113 INHIBITOR INCLUSION COMPLEX NITROGEN FERTILIZER COMPOSITIONS

Nasal delivery with cyclodextrins

Feb 22, 2025Tamas Sohajdacarbohydratesantiviral, cyclodextrin, nasal

The development project of Università di Pavia is a fantastic example of combining excipients.

Mucoadhesive and thermo-responsive in situ gelling systems were developed for nasal delivery, using hydrophobically-modified hydroxypropyl-methyl cellulose (Sangelose, SG) and beta-cyclodextrin (β-CD) derivatives, for preventing viral respiratory infections.

Silvia Rossi, Barbara Vigani & colleagues

Development of a nasal spray based on cyclodextrin/hydrophobically-modified hydroxypropyl-methyl cellulose for the prevention of viral respiratory infections – ScienceDirect

Bad Hair Day? Cyclodextrins to the Rescue!

Feb 17, 2025Tamas SohajdaToday's cyclodextrincosmetics, cyclodextrin

today’s cyclodextrin:
It’s Monday.
You are not in the mood to get up. To work.
And your hair sucks too.

But cyclodextrins can help!

Cyclodextrins were not yet utilized in personal care products in 1978, during the golden era of shiny hairstyling epitomized by the release of Grease. Had they been available, John Travolta could have made great use of the innovation described here. Tokyo-based Arimino Co., Ltd., founded in 1946 and specializing in hair and skin cosmetics—including hair color, styling products, shampoos, and skincare—has introduced a breakthrough product: Arimino Men Freeze Keep Grease. This scented hair grease for men incorporates native beta-cyclodextrin and hydroxypropyl beta-cyclodextrin as fragrance-retention agents. According to the company’s website (https://www.arimino.co.jp/), the product exemplifies their innovative use of cyclodextrins, which are featured across numerous offerings on their site. Among these, Arimino Men Freeze Keep Grease stands out as a truly remarkable development.