today’s cyclodextrin:
I love this invention from Biomeme, Inc. for processing a target nucleic acid sequence.
The inventors – Jonathan H. & Stephen Judice – use cyclodextrin to stabilize an enzyme and nucleic acids.
CDs can also shorten a cycle threshold value or a time to result value in the nucleic acid amplification and lower a detection limit.
Read the patent here: WO2025049920 METHODS AND COMPOSITIONS FOR SAMPLE PROCESSING
Today’s cyclodextrin is this great patent from Roquette‘s team, Tao Peng, Lucas Goh, Jeff Chang Shih Chieh on a new class of Lipid nanoparticles (LNPs) that can be used for nucleic acid delivery, wherein LNPs comprise a nucleic acid and a nonionic or cationic cyclodextrin compound.
How do you see the future of CDs in gene therapy? Will we see solutions commercialized in the future? In GENEGUT we certainly work towards this goal!
WO2024125823 LIPID NANOPARTICLES FOR NUCLEIC ACID DELIVERY (wipo.int)
A fascinating patent application by Hologic, Inc. using CDs in enzyme formulations for nucleic acid amplification. The compositions are also useful in mitigating the inhibitory effect of sample extraction detergents.
See the full patent on PatentScope
