IgG N-Glycosylation Is Altered in Coronary Artery Disease
Coronary artery disease (CAD) is the most common cardiovascular disease, and previous studies have shown a significant association between N-glycosylation and the development of atherosclerotic plaques. Genos Ltd, Sveučilište u Rijeci / University of Rijeka and University of Zagreb/Sveuciliste u Zagrebu teamed up to determine whether the N-glycome of immunoglobulin G is associated with the disease as N-glycans are known to alter the effector functions of IgG, which may enhance the inflammatory response.
The most notable differences were observed in women, where the presence of sialylated N-glycan structures was negatively associated with CAD. The obtained data provide insight into the IgG N-glycome composition in CAD as well as the biomarker potential of IgG N-glycans in CAD.
Barbara Radovani, Frano Vučković, Aldo Pietro Maggioni, Ele Ferrannini, Gordan Lauc and Ivan Gudelj