Interesting conceptual comparison of Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives by László Jicsinszky, Giancarlo Cravotto, et al. from the University of Turin.
See the full article in Molecules.
Have you always been fascinated by the creation and limitless use of rotaxanes like me? If so, this review is for you on their sequence-controlled synthesis.
National University of Singapore, Northwestern University – Han Han, James Seale, Liang Feng, Yunyan Qiu, Fraser Stoddart
From peptides to sugars: Design, Synthesis, and Characterization of Stapled Oligosaccharides. Oligosaccharide stapling increases enzymatic stability and cell penetration, opening new opportunities for using glycans in medicinal chemistry. – Max Planck Institute Manuel Garcia Ricardo, Emelie Ellen Reuber, Ling Yao, José Angel Danglad-Flores, Martina Delbianco, Peter Seeberger
Wonderful chemistry and insightful new possibilities.
Olivier Renaudet, David Goyard, Ángela Martín-Serrano Ortiz and Didier Boturynlick from Université Grenoble Alpes presents click chemistry to decorate synthetic multivalent scaffolds with glycans to mimic the cell surface glycocalyx and to develop applications in glycosciences.
Great reivew on glycoconjugates, their synthesis and pharmaceutical applications from Scripps Research (Sachin S. Shivatare, PhD, Vidya Shivatare and Chi-Huey Wong)
Covalent linkages are engineered between proteins and carbohydrates under biocompatible conditions. Genetically encoding the chemical crosslinking of proteins to carbohydrates offers a solution to address the low affinity and weak strength of protein–sugar interactions.
The University of California, San Francisco – Shanshan Li, Nanxi Wang, Bingchen Yu Wei Sun Lei Wang present pure beauty!
Read the full article on nature.com
Hyaluronic acid-related oligosaccharides were evaluated as potential antiangiogenic agents by N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences – Nadezhda Ustyuzhanina Nikolay Nifantiev
Link to the full article on ScienceDirect
DOI: https://doi.org/10.1016/j.carres.2022.108701Get rights and content
A new automated glycan synthesizer offering one-pot chemical glycosylations in the solution presented by Sir Fraser’s team from Northwestern University: Yong Wu, Yunyan Qiu, and Yuanning Feng
https://pubs.acs.org/doi/10.1021/acscentsci.2c01043
What a great day when we can celebrate Carolyn Bertozzi, a pioneer in glycochemistry, and the fathers of click reaction Barry Sharpless and Morten Meldal, whose innovation we use day-by-day in our humble research.
Thank you for your groundbreaking work that enables many and more new discoveries!
Automated solution-phase multiplicative synthesis of complex glycans enabled by preactivation-based, multi-component, one-pot glycosylation and continuous multiplying amplification published by Peking University. Wonderful!
