The retinol-loaded microneedles
Today’s cyclodextrin is about microneedles.
Cyclodextrins are emerging as valuable excipients in microneedle-based drug delivery systems due to their unique ability to form inclusion complexes with a wide range of therapeutic molecules, and the fact that such complexes can often form microneedles on their own.
By enhancing the solubility, stability, and bioavailability of drugs, cyclodextrins improve the efficiency of transdermal delivery through microneedles and can also facilitate the controlled release of active ingredients, offering a promising strategy for the delivery of poorly water-soluble compounds or sensitive biomolecules.
Incorporating cyclodextrins into microneedle matrices or coatings enables targeted, minimally invasive therapies with potential applications in vaccination, pain management, and chronic disease treatment.
And a recent, real-world example? Check out how Raphas is using CDs to stabilize retinol-loaded microneedles and achieve high transdermal delivery efficiency, thus maximizing the effect of retinol on wrinkle reduction.
Espacenet – US2025143986A1 COMPOSITION FOR MICRONEEDLE PREPARATION, COMPRISING CYCLODEXTRIN FOR RETINOL STABILIZATION, AND MICRONEEDLE PREPARED WITH SAME COMPOSITION
