Silylated-Acetylated Cyclodextrins as Chiral Sensors for the Enantiodiscrimination of Fluorinated Anesthetics

Today's cyclodextrin,

today’s cyclodextrin:
is a nice piece of research from a collaboration between Università di Pisa and CarboHyde‘s CSO, Milo Malanga investigating the use of silylated-acetylated cyclodextrins as #chiral #sensors for the enantiodiscrimination of fluorinated anesthetics

Alessandra Recchimurzo, Federica Balzano, Gloria Uccello Barretta, Luca Gherardi and Federica Aiello

See the full article here: Silylated-Acetylated Cyclodextrins as Chiral Sensors for the Enantiodiscrimination of Fluorinated Anesthetics

Thiolated cyclodextrins: A comparative study of their mucoadhesive properties

drug delivery, Today's cyclodextrin

today’s cyclodextrin:
when it comes to CDs, mucoadhesive properties are rarely in focus. But why not?
Andreas Bernkop-Schnürch’s team at Leopold-Franzens Universität Innsbruck investigated the mucoadhesive properties of nonionic, negatively, and positively charged thiolated cyclodextrins (CDs), including α-, β-, and γ-CDs of the low and high degree of thiolation.
In conclusion, a high degree of thiolation and the introduction of cationic charges are mainly responsible for the high mucoadhesive properties of CDs and generate, GCD derivatives do better in this aspect.

See the full article here: Thiolated cyclodextrins: A comparative study of their mucoadhesive properties

High-efficiency gold recovery by additive-induced supramolecular polymerization of β-cyclodextrin

Today's cyclodextrin

today’s cyclodextrin:
Developing an eco-friendly, efficient, and highly selective gold-recovery technology is needed in order to maintain a sustainable environment and improve the utilization of resources. Northwestern University and University of South Florida report an additive-induced gold recovery paradigm based on precisely controlling the reciprocal transformation and instantaneous assembly of the second-sphere coordinated adducts formed between β-cyclodextrin and tetrabromoaurate anions.
The efficiency of gold recovery reaches 99.8% when dibutyl carbitol is deployed as the additive. In a laboratory-scale gold-recovery protocol, over 94% of gold in electronic waste was recovered at gold concentrations as low as 9.3 ppm. This simple protocol constitutes a promising paradigm for the sustainable recovery of gold, featuring reduced energy consumption, low-cost inputs, and the avoidance of environmental pollution.
Bo Song, Charlotte Stern, George Schatz, Wenqi Liu and Fraser Stoddart et al.

See the full article here: High-efficiency gold recovery by additive-induced supramolecular polymerization of β-cyclodextrin

Controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From design to clinical performances

Today's cyclodextrin,

today’s #cyclodextrin:
achieving controlled release with cyclodextrins can be really challenging, yet it is doable. In fact, there are multiple strategies to get there. In this review, Jana Ghitman and Voicu Stefan Ioan collected different approaches of cyclodextrins-based drug delivery forms that are suitable for co-delivery systems, non-viral vectors for gene delivery, and theranostics.
This review presents the latest achievements in nanoparticle-based supramolecular architectures, taking into account the main synthesis methods and the stimuli that control the release (light-responsive, pH-responsive, redox-responsive, and multi-responsive). The review also presents applications and also the present status regarding commercial systems based on cyclodextrins and their characteristics.

See the full article here:

Controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From design to clinical performances


Method for Reduced Aggregate Formation in Downstream Processing of Bispecific Antigen-Binding Molecules

Today's cyclodextrin, ,

This is a great example of using CDs in a downstream processing method to produce bispecific antigen-binding molecule. In Amgen‘s invention, β-CD is applied in the process either in a buffer applied in the filtration step or added to the filtration pool after the UF/DF filtration step to keep the product in a non-aggregated form.
Yan Wang; Nicholas Marchand; Robert Brake; Maria Perry; Ashish Sharma; Eugene Sun

See the full patent here.

Rechargeable films for protection of dry foods: A sustainable method for covalent grafting of β-cyclodextrin-thymol complex on PET/viscose platform

Today's cyclodextrin

This is a bit of food industry, a bit of agriculture: rechargeable materials for the effective protection of dry food products were developed by Stella Kiel and Elena Poverenov at Volcani Institute. β-cyclodextrin-thymol inclusion complex was covalently grafted on a solid platform and demonstrated antimicrobial properties preventing mold propagation in wheat grains. The treated grains showed normal germination abilities verifying that the prepared materials can protect dry food products without using harmful chemicals. The suggested approach can be extended to other applications and active agents. A combination of rechargeable films with natural volatiles can be an effective platform for sustainable active materials for food protection and in other fields such as agriculture, cosmetics, and medicine.

See the full article here

Templated Enzymatic Synthesis of δ-Cyclodextrin

Today's cyclodextrin

Recently, I tried to summarize in a blog post, how CDs are made from starch. Although such technologies have been used for decades, there is room for improvement for some derivatives. Sophie Beeren, Andreas Erichsen and Günther Peters at DTU – Technical University of Denmark explore this room using bolaamphiphile templates to produce δ-CD with unprecedented yields in an enzyme-mediated dynamic combinatorial library of cyclodextrins. This technology can open a new and more efficient way to produce some native cyclodextrins. Or even derivatives

See the article here.

See the Cyclodextrin Tales: From Starch to Cyclodextrins: Understanding the Production Process

Formulation, composition or foodstuff additives for the modification of glycemic response methods of manufacturing and using the same 

Today's cyclodextrin,

The story of two stone and one bird:
It is very rare that different cyclodextrins are combined in the same formulation, but there are examples on the market. Hoow Foods‘s invention uses one CD which hides the unpleasant taste of any phenylpropanoid from the sensory receptors. This will have the added advantage that the phenylpropanoids will be protected from the acidic environment of the stomach allowing more of them to reach the intestines. Adding a second cyclodextrin that has not been complexed makes the composition behave similarly to known sugars and starches thereby minimising any effect on the texture of the foods to which it is added.

See the full patent on Espacenet

Dimethyl-α-cyclodextrin induces capacitation by removing phospholipids from the plasma membrane of mouse sperm 

Today's cyclodextrin

This is a sometimes forgotten application in the biotechnology field: fertilization. Capacitation is an important event in the completion of fertilization by mammalian sperm. cholesterol efflux is a trigger of capacitation. In general, cholesterol acceptors of albumin and β-cyclodextrins are used to induce capacitation during in vitro fertilization. Kumamoto University, JAPAN published a study using dimethyl-α-cyclodextrin (DMACD) that induced sperm capacitation and promoted fertilization ability better than other CDs before, highlighting the role of not only cholesterol but also other phospholipids in the process. These findings suggest that phospholipid efflux is a novel trigger of capacitation. Increasing the choice of sperm capacitation inducers may be useful for improving in-vitro fertilization (IVF) techniques in mice and various species in which it has been difficult to produce embryos by IVF.

See the full article here.