Today’s cyclodextrin: CDs used to formulate propolis for pharmaceutical and cosmeceutical applications including anti-skin cancer compositions by Owen Catchpole
Detailed investigation and influence of oxidation degree on synthesis, characterization and antibacterial activity of β- cyclodextrin
Today’s cyclodextrin: Did you know that some CDs also possess antimicrobial activity?
In this study by Ayhan Bergal and Muberra Andac oxidized β-cyclodextrins (OX-β-CDs) were obtained and aldehyde (CHO) groups were successfully introduced. Antibacterial activity of OX-β-CDs was investigated against both Gram-negative and Gram-positive bacteria by using the minimal inhibitory concentration. The results showed that OX-β-CDs possessed good antibacterial activity, which can destroy the bacterial cell wall, and may be used as an antibacterial agent.
Functionalization of breast implants by cyclodextrin in-situ polymerization: a local drug delivery system for augmentation mammaplasty
Today’s cyclodextrin is fascinating both form the chemisty and the application point of view. The objective was to functionalize commercially available silicone breast implants with smooth and textured surfaces through in-situ polymerization of two CDs: β-CD/citric acid and 2-hydroxypropyl-β-CD/citric acid. This functionalization serves as a local drug delivery system for the controlled release of therapeutic molecules that potentially can be a preventive treatment for post-operative complications in mammaplasty interventions.
Jacobo Hernandez-Montelongo et al
Today’s cyclodextrin in 99% of cases, I admire and enjoy innovative applications of CDs. Yet this, I find gross.
Cigar-flavored chewing tobacco where cigar essence is matched with hydroxypropyl-beta-cyclodextrin to achieve a stable slow-release effect.
Would you try it?
Intelligent and Active Packaging: A Review of the Application of Cyclodextrins for Improvement Food Quality
Today’s cyclodextrin is a bit neglected, yet very important topic: Application of Cyclodextrins for Improvement Food Quality via Intelligent and Active Packaging
Did you know that CDs can be used to interact with the product or its environment to improve one or more aspects of its quality or safety? A known problem with some of these types of packaging is that the bioactive compounds that are housed in the CD can interact with food and can modify its taste, smell, color and/or texture.
A bright team from Universidad de Guadalajara dives into the topic and comes up with practical suggestions
Intelligent and Active Packaging: A Review of the Application of Cyclodextrins for Improvement Food Quality[v1] | Preprints.org
Cyclodextrin-Coordinated Liposome-in-Gel for Transcutaneous Quercetin Delivery for Psoriasis Treatment
This is some fancy drug delivery: Cyclodextrin-Coordinated Liposome-in-Gel
Psoriasis is a chronic inflammatory skin disease that is difficult to treat. Quercetin is a dietary flavonoid known for its anti-inflammatory effects and safe use in humans. However, the topical application of quercetin for psoriasis treatment presents a significant challenge due to its poor water solubility and low stability in semisolid preparations, where it tends to recrystallize. This work presents a novel liposome-in-gel formulation for the quercetin-based topical treatment of psoriasis. The quercetin-loading liposomes are stabilized by hydroxypropyl-β-cyclodextrin (HPCD), which interacts with phospholipids via hydrogen bonding to form a layer of an HPCD coating on the liposome interface, thus resulting in improved stability.
The in vivo results showed that the topical QT HPCD-liposome-in-gel improved the treatment efficacy of psoriatic plaque compared to free QT. It alleviated the symptoms of skin thickening and downregulated proinflammatory cytokines, including TNF-α, IL-17A, and IL-1β. The results suggested that the HPCD-coordinated liposome-in-gel system could be a stable carrier for topical QT therapy with good potential in psoriasis treatment.
is a fascinating review again from Susana Santos Braga, now about using CDs in #dentistry.
Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literature. Moreover, cyclodextrins are under study for the development of materials used in various techniques of dental repair, such as fillings, cements and binders therein. Finally, the prospect of the use of cyclodextrin-based delivery systems for the oral cavity is introduced, with a focus on new cyclodextrin molecules with dual action as bone-targeting agents and osteogenic drugs, and on new cross-linked cyclodextrin particles with a high drug loading and sustained drug delivery profile for the treatment of diseases that require prolonged action, such as periodontitis. In conclusion, cyclodextrins are herein demonstrated to act as versatile and multi-action ingredients with a broad range of applications in dentistry.
Influence of Encapsulation of Propolis Extract with 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) on Polyphenolic Contents during In Vitro Simulation of Digestion
A great case study of how combining CDs with a complex material like propolis could lead to improved properties. The propolis complex, in the form of water-soluble powder of propolis extract with the carrier 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared and superior bioaccessability for polyphenolic components shown.
Croatian veterinary institute – Ksenija Šandor et al
Applied Sciences | Free Full-Text | Influence of Encapsulation of Propolis Extract with 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) on Polyphenolic Contents during In Vitro Simulation of Digestion (mdpi.com)
A Universal Cyclodextrin-Based Nanovaccine Platform Delivers Epitope Peptides for Enhanced Antitumor Immunity
Currently, there is still an intense demand for a simple and scalable delivery platform for peptide-based cancer vaccines. This Cyclodextrin-based polymer nanovaccine platform (CDNP) is designed for the codelivery of peptides with two immune adjuvants that is broadly applicable to epitope peptides with diverse sequences. Specifically, the cyclodextrin-based polymers are covalently linked to epitope peptides via a bioreactive bond-containing cross-linker and then physically load with R848 and CpG to obtain CDNP. The CDNP efficiently accumulats in the lymph nodes, greatly facilitating antigen capture and cross-presentation by antigen-presenting cells. The immunogenicity of the epitope peptides is significantly enhanced by the codelivery and synergy of the adjuvants, and the CDNP shows the ability to inhibit tumor progression in diverse tumor-bearing mouse models.
This is an analytical application by Agilent Technologies. This patent highlights how CDs can be used in sample preparation to reduce matrix via alpha-CD supported solid phase sorbent.
See the full patent on Patentscope: EP4226946 METHOD FOR REDUCING MATRIX EFFECTS IN ANALYTICAL SAMPLE (wipo.int)