🚀 Cyclodextrins: Beyond Pharma! 🚀
From dietary supplements and cosmetics to energy, agriculture, and even space exploration, cyclodextrins are transforming industries in unexpected ways. 🌍✨
Curious about their potential? Tune into the podcast to explore the science and real-world applications of these versatile molecules! 🎧
Subscribe for updates and more episodes: (3) Season 2 – Episode 1 – cyclodextrins beyond pharma | LinkedIn
Today’s cyclodextrin is about replacing albumin with a magic combo of Polyvinyl alcohol, N-acetylcysteine, and methyl-β-cyclodextrin.
Albumin is a crucial component of serum-free media, playing a significant role in ex vivo cell culture as a lipid carrier and antioxidant.
Polyvinyl alcohol (PVA), N-acetylcysteine (NAC), and methyl-β-cyclodextrin (M-β-CD) were tested as an albumin substitute combination (PNM) and optimized their concentrations by using response surface methodology.
Verification of functions of PNM showed that intracellular fatty acid levels, cholesterol consumption rates, and the pSTAT5 level in the PNM group were significantly higher than those in the 0.75 g/L BSA group.
Reactive oxygen species levels remained controlled, and mitochondrial membrane potential was similar. These findings suggested that the PNM can effectively replace the functions of BSA as a fatty acid carrier, antioxidant, and, to some extent, a cholesterol carrier. This study provides insights for developing chemically defined media to prepare clinical-grade NK cells efficiently.
Today’s yclodextrin:
I have often been asked about the CD-based products delivered subcutaneously by many partners.
I always had to refer to research and clinical trials, yet there were no marketed products.Now, that era is over, here you can see the first s.c. delivered, HPBCD-supported drug (Tesamorelin F8 by Theratechnologies Inc.) approved by the FDA:
Theratechnologies Receives FDA Approval for EGRIFTA WR™ (Tesamorelin F8) to Treat Excess Visceral Abdominal Fat in Adults with HIV and Lipodystrophy | Theratechnologies Inc.
Tesamorelin for injection is the only medication approved in the U.S. for the reduction of excess abdominal fat in adults with HIV who have lipodystrophy.
Today’s cyclodextrin is about the Removal of Heavy Metals in Soil Systems
This review provides a comprehensive overview of environmental remediation strategies using cyclodextrin and examines the effectiveness of methylated gamma-cyclodextrin (M-γ-CD) for the elimination of toxic elements from impure soil matrices.
M-γ-CD has emerged as a potent agent for treating soil impurities with noxious metals forming inclusion complexes with heavy-metal ions, thereby cumulating the aqueous solubility and efficiency of pollutants in environmental applications and improving soil bioremediation.
Dr Nontobeko Gloria Maphuhla and Dr OpeOluwa Oyedeji
Today’s cyclodextrin is about stabilizing insulin.
Using freeze drying to form a heat-stable tablet in a single-step process, hydroxypropyl beta cyclodextrin (HP-β-CD) encapsulated lipophilic ion-pair complex of insulin using bile salt achieves demonstrated intestinal absorption and sustained glucose levels.
The tablets produced using this simple approach with only two excipients offer protection from enzymatic and stomach acid degradation and facilitate insulin uptake, without any need for specialized drug manufacturing or enteric coating.
The convenient presentation of insulin as a thermostable oral tablet presents a low-cost scalable manufacturing method that simplifies the logistics of storage, transport, and distribution in any setting, including areas where cold storage maybe limited or unavailable.
Read the full paper from Manshun Lai, Changcheng Zhu, Jaclyn Delarosa, and Manjari Lal PhD here: A unique two-excipient heat stable tablet formulation of oral insulin: preliminary results | bioRxiv
today’s cyclodextrin:
CDs supporting the synthesis of renewable chemicals
Cyclodextrin-mediated aqueous biphasic systems are a potent way to recycle homogeneous catalysts, also applicable to producing highly demanded renewable chemical intermediates.
Thomas Seidensticker and his team from TU Dortmund University present the Rh-catalyzed, cyclodextrin-mediated, aqueous biphasic hydroformylation of methyl 10-undecenoate (from castor oil) and methyl 9-decenoate (from rapeseed oil) to produce methyl 12-oxododecanoate and methyl 11-oxoundecanoate, respectively, with high yields and productivity.
Using cyclodextrins (CDs) as scaffolds for artificial enzymes has emerged as a promising strategy for improving catalytic processes.
CDs are still widely used in the design of artificial enzymes and in understanding the enzymatic reaction mechanisms, especially in applications that require the modification of substrate solubility or the stabilization of reaction intermediates.
This review summarizes the CD-based artificial enzyme development, discusses key challenges and limitations of syntheses, and explores potential strategies to improve their catalytic activity.
Great paper from László Jicsinszky, Katia Martina, Luisa Boffa, Giancarlo Cravotto
today’s cyclodextrin:
I love this invention from Biomeme, Inc. for processing a target nucleic acid sequence.
The inventors – Jonathan H. & Stephen Judice – use cyclodextrin to stabilize an enzyme and nucleic acids.
CDs can also shorten a cycle threshold value or a time to result value in the nucleic acid amplification and lower a detection limit.
Read the patent here: WO2025049920 METHODS AND COMPOSITIONS FOR SAMPLE PROCESSING
What to Expect?
Explore the evolving landscape of cyclodextrin-based drug delivery, from established uses to groundbreaking innovations. Our expert speaker will dissect key advancements, addressing both challenges and transformative opportunities that enhance therapeutic efficacy.
Key Focus Areas:
Monoclonal Antibodies
Gene Therapy
Vaccines
Biotechnology
You can register here: Cyclodextrin Masterclass IV – CarboHyde
Today’s cyclodextrin is my next cyclodextrin patent.
I have been advocating for improved solutions for agriculture formulations for a long time.
Cyclodextrins can help improve the biological activity and uptake of pesticides and insecticides, improve their penetration, reduce their applied dose (and burden on the environment) and even achieve controlled release of these agents.
US20250057161 USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM
This is what our patent with ADAMA Ltd. is about.
Shimon Amselem, Lital Koren, Zoltán Fülöp, István Puskás
