Can cyclodextrins and dextrans revolutionize gut health?

Today's cyclodextrin,

This review highlights the exciting potential of these compounds to support the gut microbiome. Conducted in collaboration with Université Clermont Auvergne, the study was authored by Anna G. and Emmanuelle Lainé, under the supervision of Judyta Cielecka-Piontek.

It explores how cyclodextrins and dextrans can promote the growth of beneficial bacteria like Bifidobacterium and Lactobacillus and enhance the production of short-chain fatty acids essential for gut health. This review also sheds light on their overlooked prebiotic potential.

The gut microbiome plays a key role in digestion, metabolism, and overall vitality.

Dive into the insights provided in this comprehensive review: How Do Cyclodextrins and Dextrans Affect the Gut Microbiome? Review of Prebiotic Activity

Methyl-Beta-Cyclodextrin Restores Aberrant Bone Morphogenetic Protein

Today's cyclodextrin,

Today’s cyclodextrin is about their potential in osteoporosis.

This paper was published by University of Delaware who found that after treating bone marrow stromal cells with methyl-β-cyclodextrin, a disruptor of cellular endocytosis, bone morphogenetic protein (BMP) signaling is restored in 15-month-old mice, as shown by von Kossa assays.

MβCD has the potential to restore BMP receptor type Ia function, and the BMP signaling pathway offers a promising avenue for future OP therapies.

Congrats to Daniel Halloran, Venu Pandit, Kelechi Blessing Chukwuocha and Anja Nohe for their great work!

Methyl-Beta-Cyclodextrin Restores Aberrant Bone Morphogenetic Protein 2-Signaling in Bone Marrow Stromal Cells Obtained from Aged C57BL/6 Mice

Degradable plastics including movable cyclodextrin crosslinking units

Today's cyclodextrin,

Today’s cyclodextrin is about enforcing recyclable plastic with CDs.

A collaborative work performed by Nara Laboratory, Kyoeisha Chemical Co. and various departments of Osaka University might make a step further in achieving a sustainable society with the development of advanced degradable plastics including movable cyclodextrin crosslinking units.

In a study published recently in Chem [link to the artickle], the researchers have revealed that developing polymers with movable crosslinks not only increases their strength but also promotes degradation by enzymes under mild conditions.

The movable crosslinks are cyclodextrins, which are threaded on one polymer strand and attached to another, endowing the resulting plastics with increased toughness and durability. Cyclodextrins being nontoxic, biodegradable, and widely available, making them attractive as a polymer component.

The cyclodextrin crosslinks also enabled the degradation of the polymers during subsequent enzymatic treatment because their bulky structure increased the free volume in the polymer network, which improved access of the enzyme to the target cleavage sites on the polymer chains.

These advanced biodegradable plastics can readily be broken down by enzymes into useful precursor molecules that could be reused in further materials, suppressing waste generation and contributing to the development of a sustainable industry.

Preparation of ingredients for producing bread with reduced glycemic index 

Today's cyclodextrin,

Today’s cyclodextrin is about producing bread, of course, with a low glycemic index.

This invention from Universidad de Granada describes a preparation of ingredients that includes alpha-cyclodextrin and other ingredients. These ingredients permit the production of a dough suitable for traditional processing and making bread with a reduced glycemic index.

This preparation adds at least 5 g ACD to 50 g starch.

In the Scientific Opinion of the Panel on Dietetic Products, Nutrition and Allergies of the European Food Safety Authority (EFSA), two intervention studies showed that alpha-cyclodextrin added to starch significantly affected the postprandial glycemic response without disproportionately increasing the postprandial insulin response. This did not occur when it was added to sucrose.

Based on the data presented, the Panel concluded that a cause-and-effect relationship is established between the consumption of alpha-cyclodextrin with starch-containing meals and a reduction of postprandial glycemic response. The panel considers that at least 5 g of alpha-cyclodextrin per 50 g of starch should be consumed to obtain the claimed effect.

The target population of this health claim is adults who wish to reduce their postprandial glycemic response [EFSA. Scientific Opinion on the substantiation of health claims related to alpha-cyclodextrin and reduction of post-prandial glycaemic responses (ID 2926, further assessment) according to Article 13 (1) of Regulation (EC) No 1924/2006. EFSA Journal 2012 10 (6): 2713].

You can read the patent here: Espacenet – Description

carbohyde, alfa-cyclodextrin, producing bread

Direct Continuous Flow Synthesis of Two Difficult Polypeptides Using β-Cyclodextrins

Today's cyclodextrin,

Direct Continuous Flow Synthesis of Two Difficult Polypeptides Using β-Cyclodextrins

Wonderful paper from Hungary by Szaniszló Szebasztián, Gitta Schlosser, Viktor Farkas and Perczel András

Results show that the use of β-CyD as an additive results in a significant (8–19%) increase in the purity of the crude polypeptide compared to that determined by our reference method.

Direct Continuous Flow Synthesis of Two Difficult Polypeptides Using β-Cyclodextrins | The Journal of Organic Chemistry

Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery

Today's cyclodextrin, drug delivery

Check out our latest cyclodextrin review fresh from the oven on cationic cyclodextrins for drug and nucleic acid delivery.

This contribution to science is a fruit of our collaboration with Eötvös Loránd University and Semmelweis University (Szabolcs Béni and Adila Nazli).

Special thanks to Milo Malanga PhD and Tamas Sohajda as well as Bicyclos HEurope for the funding.

Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery

Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery

Disulfide stoppered polyrotaxanes with enhanced cellular uptake and intracellular cyclodextrin release

Today's cyclodextrin,

Today’s cyclodextrin:
Polyrotaxanes are molecular necklaces composed of polymers, threaded macrocycles, and bulky stopper molecules to inhibit the decomposition of the first two.

These supramolecular assemblies are promising active ingredients for treating lysosomal storage disorders.

This study aimed to synthesize such polyrotaxanes with a novel, simple method, resulting in high threading efficacy, enhanced cellular uptake, and intracellular cyclodextrin (CD) release.

Great work from Andreas Bernkop-Schnürch, Gergely Kali and their team at Bernkop-Schnürch Research Group.

Disulfide stoppered polyrotaxanes with enhanced cellular uptake and intracellular cyclodextrin release – ScienceDirect

Disulfide stoppered polyrotaxanes with enhanced cellular uptake and intracellular cyclodextrin release

Anti-inflammatory effects of cyclodextrin nanoparticles enable macrophage repolarization and reduce inflammation

Today's cyclodextrin,

Fantastic antiinflammatory cyclodextrin application by Goethe University Frankfurt

Inflammation plays a critical role in the pathophysiology of many diseases, and dysregulation of the involved signaling cascades often culminates in uncontrollable disease progression and, ultimately, chronic manifestation.

Cyclodextrins (CDs), particularly β-CD, have gained attention as biocompatible biomaterials with intrinsic anti-inflammatory properties, and chemical modification of their backbone offers a promising strategy to enhance their physicochemical properties, adaptability, and therapeutic potential.

In a human macrophage model, CD nanoparticles demonstrated superior anti-inflammatory activity, with derivative-specific effects tied to their physicochemical properties, surpassing the soluble β-CD control.

The findings of this study underscore the potential of cyclodextrin-based nanoparticles as versatile biomaterials for treating the complex pathophysiology of various acute and chronic inflammation-associated disorders.
Anti-inflammatory effects of cyclodextrin nanoparticles enable macrophage repolarization and reduce inflammation | Discover Nano

Pediatric Orally Disintegrating Tablets (ODTs) with Enhanced Palatability Based on Propranolol HCl Coground with Hydroxypropyl-β-Cyclodextrin

Today's cyclodextrin, , ,

Today’s cyclodextrin is a nice case study of creating Pediatric Orally Disintegrating Tablets with Enhanced Palatability.

This work by Università degli Studi di Firenze and University of Milan aimed to exploit cyclodextrin complexation by cogrinding to develop orally disintegrating tablets (ODTs) endowed with reliable dosing accuracy, good palatability and safety, ease of swallowability, and ultimately better compliance for both pediatric patients and caregivers.

Such a new dosage form of propranolol with HPBCD could represent a valid alternative to the common extemporaneous preparations, overcoming the lack of solid formulations of propranolol intended for pediatric use.

Marzia Cirri, Paola Mura, Francesca Maestrelli, Simona Benedetti and Susanna Buratti

Pediatric Orally Disintegrating Tablets (ODTs) with Enhanced Palatability Based on Propranolol HCl Coground with Hydroxypropyl-β-Cyclodextrin