Functionalization of cotton nonwoven with cyclodextrin/lawsone inclusion complex nanofibrous coating for antibacterial wound dressing

Today’s cyclodextrin is a new type of wound dressing developed at Cornell University by Tamer Uyar‘s team.

Bioactive compounds like lawsone offer dual benefits of wound healing and infection prevention, however, their limited solubility and viability hinder their applications. To address this, Hydroxypropyl-beta-cyclodextrin (HP-β-CD) and Hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) were employed.

Electrospinning yielded smooth and uniform nanofibers with an average diameter of ∼300–700 nm. The nanofibers exhibited ∼100 % loading efficiency of lawsone and its rapid release upon dissolution.

Notably, antibacterial assays demonstrated the complete elimination of Escherichia coli and Staphylococcus aureus colonies. The CD/lawsone nanofibers also showed suitable antioxidant activity ranging from 50% to 70%.

Functionalization of cotton nonwoven with cyclodextrin/lawsone inclusion complex nanofibrous coating for antibacterial wound dressing – ScienceDirect

Comparative investigation of pulmonary vasodilating effects of inhaled Nitric Oxide (NO) gas therapy and inhalation of SIN-1, a new drug formulation containing an NO-donor metabolite

Today’s cyclodextrin is a nice collaborative formulation and in vivo (porcine) study between Semmelweis University and Cyclolab R&D Ltd.
In the project, the hemodynamic effect of inhalative SIN-1a (the unstable active metabolite of molsidomine, stabilized by cyclodextrine) was studied. The pulmonary vasodilator effect of SIN-1 was dose dependent, and in case of larger dose it was comparable to that of iNO. However, the vasodilatory effects of SIN-1 inhalation was not limited to the pulmonary circulation, a significant and dose-dependent systemic vasodilation could also be documented.
My only regret here is not all contributors met the authors’ list finally.

Comparative investigation of pulmonary vasodilating effects of inhaled Nitric Oxide (NO) gas therapy and inhalation of SIN-1, a new drug formulation containing an NO-donor metabolite | European Heart Journal | Oxford Academic (oup.com)

Towards an efficient method for removing PFAS from water

Today’s cyclodextrin is highlighting a wonderful and important achievement from Aalborg University by Mads Koustrup Jørgensen and Thorbjørn Terndrup Nielsen, who are combining cyclodextrin chemistry and membrane technology in a new filtration project. They hope to present an effective and economically sustainable method for removing PFAS from our drinking water within a few years.

“In short, by rinsing a membrane in a specific alcohol solution of cyclodextrins, we can make the cyclodextrins bind to the membrane surface, making it functional for PFAS absorption without the need for complex chemistry,” says Mads Koustrup Jørgensen.

Learn more about the project here: Towards an efficient method for removing PFAS from water – Aalborg University (aau.dk)

This application relates in part to nanoparticles comprising a tobamovirus and nanoparticles comprising a tobamovirus and beta-cyclodextrin

today’s cyclodextrin:
is a fascinating and one-of-a-kind drug delivery vehicle. Nicole Steinmetz and Ivonne González-Gamboa created nanoparticles based on tobamovirus, to which they covalently attached beta-cyclodextrin that can non-covalently bind one or more active ingredients.
Such chemistry is not easy; you can learn more about it here: Custom synthesis of cyclodextrins – www.carbohydesolutions.com

METHODS AND COMPOSITIONS COMPRISING TOBACCO MILD GREEN MOSAIC VIRUS (TMGMV)

Acute Effects of 30 g Cyclodextrin Intake during CrossFit® Training on Performance and Fatigue

Today’s cyclodextrin:
Ready for some weekend workout? Have you planned to take some cyclodextrin afterward?
This study by Ismael Martínez Guardado and colleagues looks into the effect of taking 30 g cyclodextrin (Cluster Dextrin® – which is not clear to me what kind of cyclodextrin is, if any) during CrossFit Training on Performance and Fatigue. Although some differences were found, supplementation with 30 g of cyclodextrin did not have any metabolic or performance effects in CrossFit tests.

JFMK | Free Full-Text | Acute Effects of 30 g Cyclodextrin Intake during CrossFit® Training on Performance and Fatigue (mdpi.com)

Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate

Today’s cyclodextrin:
One of the greatest features of CDs is that with a proper application (especially when the local CD concentration is relatively high), they can not only improve the solubility but also the permeability of compounds. For example, in the case of a peroral application, let’s say an orally disintegrating tablet. Not to mention that their taste masking potential is also of use in this case. 3 birds with one stone!

In this paper, you can find a great example of such a smart application. If you are interested in developing similar formulations, check out the first steps here: Formulation development – www.carbohydesolutions.com

Pharmaceutics | Free Full-Text | Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate (mdpi.com)

Washable ink composition

Today’s cyclodextrin is another industrial application, now from the material sciences: a washable ink!
The cyclodextrin is said to be included to improve the washability and vividness of the shades of a washable aqueous ink composition. According to the patent, in this particular application HPBCD is used, yet I think that would be more composition dependent.

Link to patent: https://worldwide.espacenet.com/publicationDetails/claims?CC=US&NR=2023383132A1&KC=A1&FT=D&ND=&date=20231130&DB=EPODOC&locale=en_EP

Development of abiraterone acetate tablets with enhanced oral bioavailability

Today’s cyclodextrin
Reading this paper from Yeungnam University by Jong Oh Kim et al reminded me about a core application of CD’s: improving oral bioavailability of compounds. While this feature does not work generally on all compounds, it certainly does on the ones, where the poor solubility is the main cause of the low oral bioavailability. On the other hand, this feature of CD’s often make developing generic drugs with this excipients impossible, while creating improved/added value reformulations of repurposed APIs remains a target use.

If you have projects like this on your table, you might find it useful to check this website: Development of abiraterone acetate tablets with enhanced oral bioavailability | Journal of Pharmaceutical Investigation (springer.com)

Cyclodextrin incorporated silicone materials and their use as carriers for actives

today’s cyclodextrin is an innovation from WACKER (Amitabha MitraMegan GutmanChristian Hartman and Vera Popova) where cyclodextrins are part of a silicone composition creating articles for absorption, encapsulation and delivery of actives and other compounds. Example of such articles could be transdermal patches, PSAs, medical device, membranes, gels, clothing or other wearable materials, etc. The invention can be used for various applications including cosmetics, medical, home care, textiles, industrial and others.

WO2023208316 CYCLODEXTRIN INCORPORATED SILICONE MATERIALS AND THEIR USE AS CARRIERS FOR ACTIVES (wipo.int)

Thermal response liquid intelligent window and preparation method

today’s cyclodextrin is something smart and unique – heat-responsive, intelligent window. In practice, temperature-sensitive cyclodextrin as a solute and water and glycerol as solvents are injected into an interlayer of a double-layer window panel to obtain the thermal response liquid intelligent window. The thermal response liquid intelligent window is prepared from safe, non-toxic and environment-friendly raw materials through a simple and feasible preparation method in accordance with the green and environment-friendly concept. The window is remarkable in anti-freezing capability, is high in transparency in a cold state, is high in response speed after being heated, is quickly turned into an opaque state, and can effectively modulate the sunlight transmittance.

Please read the full patent here: Espacenet – search results