The first two years of a child (ps: Happy Birthday CarboHyde!)

The first two years of a child bring immense happiness to his/her family. Yet, it has to be recognized that it is also full of challenges, tough periods, sicknesses, and long nights for the parents. There are also many friends and family members who take part in supporting the first years of the baby. Without them, the parents just wouldn’t be able to manage on their own.

These first years are full of discovery and growth. From those first tentative steps to the emergence of words and the opening personality, every milestone reached is met with pride by loved ones. The second birthday is a reminder of the passage of time and the beauty of witnessing a child’s journey from infancy to toddlerhood.

As the child blows out the candles on the birthday cake, surrounded by adoring family and friends, there is a sense of infinite possibilities for the years that lie ahead. Happy Birthday CarboHyde

Carbohyde Welcomes French Students from Strasbourg for an Insightful Visit

We are thrilled to express our gratitude for the recent visit from a group of bright students from University of Strasbourg to Carbohyde. The enthusiasm and curiosity displayed by the students were truly inspiring.

During their visit, the students engaged in meaningful discussions, asking insightful questions about our research and development activities. It was a pleasure to witness their passion for science and witness the curiosity that drives the next generation of scientists.

At Carbohyde, we are committed to fostering an environment that encourages learning and collaboration. Hosting such dynamic groups of students aligns with our mission to inspire and contribute to the future of pharmaceutical research. We extend our heartfelt thanks to the students from Strasbourg for their keen interest and look forward to more opportunities to share our knowledge and experiences with the scientific community.

Bicyclos starting!

As we reported earlier CarboHyde is part of an EU-sponsored 4-year long staff-exhange project, Bicyclos.

Bicyclos is a staff exchange project funded by the Horizon Europe Framework Programme after successful application in the call HORIZON-MSCA-2022-SE-01-01. The project started on September 1st, 2023. We are 9 beneficiaries and 2 associated partners coming from 8 countries in Europe and America. We are all interested in fostering progress of cyclodextrins in biomedical applications.

During this project, CarboHyde staff will spend 30+ months abroad and will host students for 40+ months in the upcoming 4 years doing high level science on moonshot projects – of course, all based on cyclodextrins.

Now its time to start our first journey, as our excellent chemist, Kristóf Felegyi is going to Seville for 5 months to make some fancy compounds at the lab of Jose Manuel Garcia Fernandez.

Farewell Kristof, we expect you back soon!

Preparation process of low-irritation hair dye with color protection function

Today’s cyclodextrin:
With the party mood of the weekend approaching, let’s see an example of using CDs as hair dye components. The invention provides a low-irritation hair dye with a color protection function. As claimed, the hair dye can greatly reduce scalp irritation, reduce scalp stabbing pain and burning feelings caused by hair dyeing of consumers in the past, reduce direct contact between irritant substances and scalp, and greatly reduce scalp irritation.

Espacenet – Preparation process of low-irritation hair dye with color protection function

Welcome on board!

We are thrilled to share that our team has grown with two bright talents.

Daniel Bisericaru joined us after a few months of internship (through Università degli Studi di Torino) in the chemistry lab, has experience in the field of chemistry, synthesis and characterization of cyclodextrins and CD-based nanosponge complexes for drug delivery. Dani is a a Red Cross Volunteer, interested in the gym and applying science in it, loves travelling, food and manga.

Balázs Attila Kondoros is a formulation scientist with fresh PhD from University of Szeged in Pharmaceutical Sciences. Balázs has experience in designing and characterizing cyclodextrin formulations and interest in pharmaceutical technology. He enjoys swimming, playing video and board games.

Welcome guys, you make our team more colorful and more powerful!

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

Today’s cyclodextrin is a great review on tastemasking potential by Lena Adamkiewicz and Łukasz Szeleszczuk.
A systematic evaluation was conducted, which resulted in the selection of 67 works representing both successful and unsuccessful works describing the application of CDs as taste-masking excipients. Particular attention has been given to the methods of evaluation of the taste-masking properties and the factors affecting the outcomes, such as the choice of the proper cyclodextrin or guest–host molar ratio. The conclusions of this review reveal that the application of CDs is not straightforward; nevertheless, this solution can be an effective, safe, and inexpensive method of taste masking for pharmaceutical purposes.

Molecules | Free Full-Text | Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes (mdpi.com)

Cyclodextrins Reshaping the Future of Pharmaceuticals Webinar is available on YouTube

About the Event

We invite you to join our webinar event, which explores practical areas of developing cyclodextrin-based formulations such as manufacturing, regulatory and safety aspects along with novel applications like using them as active ingredients.

This series of educative sessions offers a comprehensive examination of the current state and future prospects of utilizing cyclodextrins in various domains, with a special focus on their use in formulations and as therapeutic agents.

Please help our work to fill this form, thanks in advance!

https://forms.gle/te1BBTgrZQ3cYgUT7

You can check it on YouTube:

Presentations (30 mn: 25 mn + 5mn Q&A), 

  • General considerations on cyclodextrins: manufacturing, challenges, and properties – Carmen Popescu and Julien Parcq (Roquette)
  • Regulatory/Safety aspects of cyclodextrins – Damien Truffin (Roquette)
  • Next generation cyclodextrins as therapeutics – Tamas Sohajda (CarboHyde)

About the Speakers

Carmen PopescuCarmen Popescu – Global Pharma/Bio Technical Developer at Roquette

Julien ParcqJulien Parcq – Manager of Functionalization of Starches, Sugars and Polyols Department at Roquette

Damien TruffinDamien Truffin – Toxicologist Expert at Roquette

Tamas SohajdaTamas Sohajada – CEO at CarboHyde

Kick-off meeting of the EU project “Bicyclos”

The kick-off meeting of the EU project “Bicyclos,” a Staff Exchanges program under the Marie Skłodowska-Curie Actions, was a resounding success. The meeting brought together a diverse group of enthusiastic participants, each representing their respective institutions and showcasing their previous work relevant to the Bicyclos project.

Participants from various research institutions and universities across Europe gathered to discuss the exciting prospects of collaboration in cyclodextrins research. As they introduced themselves, they highlighted their affiliations and previous work that directly related to the goals of Bicyclos. The collective energy and passion in the room were palpable, underlining the participants’ eagerness to contribute to this innovative project.

The event was very well organized by the project coordinator, Ilse Manet from CNR, who ensured that all participants had a clear understanding of the project’s objectives and timeline. Her attention to detail and commitment to a smooth kickoff set a positive tone for the meeting. The extra presentations on open science and data management will also be useful for the team members.

To foster team bonding and create an enjoyable atmosphere, the participants enjoyed a delightful dinner in the inner city of Bologna. This provided an opportunity for informal discussions and further strengthened the connections among the project members.

Looking ahead, the participants eagerly anticipated the next face-to-face meeting scheduled for October 2024 in Budapest. This meeting promises to be an important milestone in the project’s progress and will provide an opportunity for more in-depth collaboration and knowledge exchange.

CarboHyde was represented by Milo Malanga, CSO, and Gergely Toth, CFO.  For our company, Bicyclos presents a tremendous opportunity to advance research on cyclodextrins. The project not only facilitates the learning of their colleagues but also broadens their perspective on cyclodextrins research. It is clear that Bicyclos is not just a project but a transformative endeavor with great promise for all involved.

Team members:
CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), the Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN
CarboHyde Ltd.
Consejo Superior de Investigaciones Científicas
Hacettepe Üniversitesi
Technological University Dublin
MD USE INNOVATIONS SL
CellDynamics
Eötvös Loránd Tudományegyetem

hereinafter, jointly referred to as “Beneficiaries”

University of Buenos Aires
Cyclarity Therapeutics


GENEGUT 3rd General Assembly meeting

Last week, the GENEGUT consortium, where CarboHyde is a full partner, gathered for the project’s 3rd General Assembly meeting. This time again in-person, hosted by CarboHyde in Budapest, Hungary. The two-day meeting was a great opportunity to discuss the significant progress of GENEGUT’s first year and prepare for the next steps towards the development of an RNA-based therapy for Crohn’s Disease.

Just over 30 attendees from all 9 GENEGUT partners got together to hold this General Assembly meeting. Joined also by one of the project’s Scientific Advisory Board (SAB) members, Prof. Katie Whitehead (CMU). Prof. Dr. Csóka Ildikó from the University of Szeged, Hungary joined also as a guest lecturer and held an interesting session focusing on regulatory basics for nucleic acid APIs.

After kicking-off the day with a team-building activity, day one was dedicated to updates from the management side of the project and all its scientific work packages. The WP leads and early-career researchers presented their progress, interaction with other WPs, challenges and next steps. I think we have made significant progress over our first year and I am confident we can build on this over the coming months.” – concluded GENEGUT coordinator Prof. Caitriona O’Driscoll (UCC).

CarboHyde’s main responsibility in the project is to create a library of cyclodextrin-based compounds. Our colleague, Milo Malanga presented the progress CarboHyde’s team has achieved in the past year along the main results as well as the challenges this work involved.

Besides the focused work this workshop required from all the participants, we had the opportunity to visit some of the main attractions of Budapest, such as the Parliament and the Kossuth square and also enjoyed the local cousine. 

GENEGUT meets for 3rd General Assembly