Dr. Milo Malanga on what are cyclodextrins?

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🔎 In this video, Milo Malanga from CarboHyde explains how cyclodextrins are being harnessed to support the safe and effective delivery of RNA-based therapies for Crohn’s disease within the GENEGUT project.

🔬 GENEGUT is developing a first-in-class oral RNA-based therapy to target intestinal inflammation at its source, and cyclodextrins are playing an essential role.

The RNA delivery will be enabled by a combination approach using novel Biomaterials, including patented amphiphilic cyclodextrins and amino polyesters, are designed to protect and carry RNA through the gastrointestinal tract by forming nanoparticles.

Podcast alert – the Carbohydrate Chronicles is back with Season II

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🚀 Cyclodextrins: Beyond Pharma! 🚀
From dietary supplements and cosmetics to energy, agriculture, and even space exploration, cyclodextrins are transforming industries in unexpected ways. 🌍✨
Curious about their potential? Tune into the podcast to explore the science and real-world applications of these versatile molecules! 🎧


Subscribe for updates and more episodes: (3) Season 2 – Episode 1 – cyclodextrins beyond pharma | LinkedIn

Cyclodextrin Masterclass V

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Ready to take your cyclodextrin knowledge to the next level?

Join us for the fifth edition of the CarboHyde Cyclodextrin Masterclass, where we’ll dive deep into the technical intricacies of crafting effective cyclodextrin complexes and formulations. Whether you’re optimizing a drug delivery system or evaluating product compositions on the market, this session will arm you with practical insights and proven strategies.

Registering here is necessary to receive link to attend: https://www.carbohyde.com/cyclodextrin-masterclass-v-how-to-make-a-cyclodextrin-complex/

💡 What You’ll Learn:

Technical best practices for developing cyclodextrin complexes
Key formulation challenges—and how to overcome them
Real-world analysis of existing cyclodextrin-based products
Expert tips to improve stability, solubility, and efficacy
Presented by Dr. Tamas Sohajda (CarboHyde), this masterclass is a unique opportunity to explore the “how-to” behind successful cyclodextrin applications in pharma.

🎯 Who Should Attend?
Formulation scientists, R&D specialists, pharmaceutical developers, and anyone working hands-on with cyclodextrins.

A Comprehensive Nomenclature System for Cyclodextrins

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If there is a dream-team in cyclodextrin research, this author-crew might be the one.

By introducing this standardized nomenclature to the world of cyclodextrins, especially molecular modeling, we aim to enhance molecular design, improve reproducibility, and streamline both experimental and computational research in the CD field.

Special thanks to Angel Piñeiro and Rebeca Garcia-Fandino for the great concept, Amelia Anderson and Matthew “Oki” O’Connor (Cyclarity Therapeutics), J. D. Pipkin (Ligand Pharmaceuticals), Milo Malanga PhD, Milo, Tamas Sohajda (CarboHyde), Thorsteinn Loftsson (Oculis) and Lajos Szente (Cyclolab R&D Ltd.) for contributing.

ssrn-5174723Download

Opening new doors in the cosmetic industry

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At CarboHyde we really believe that cyclodextrins have much more to offer beyond the pharma industry and are testing the waters in new areas, like cosmetic applications.

We have a number of development projects in the area that we will share in the coming weeks.

In the meantime, you can meet Dani at Cosmoprof Worldwide Bologna if you wish to discuss how cyclodextrins are and can be used in cosmetics.

And also in daily training, 20 km walking is quite a leg-day 🙂

CarboHyde and Emoviar PharmaCon GmbH Announce Strategic Collaboration in Sustained Release Technology

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CarboHyde Zrt, a leader in cyclodextrin research and development, has entered into a strategic collaboration with Emoviar PharmaCon GmbH, a specialist in sustained release technologies.

This partnership aims to explore new business opportunities by leveraging CarboHyde’s expertise in cyclodextrins and Emoviar’s advanced sustained release formulations.

Through this collaboration, both companies will work together to identify and develop innovative applications, expanding market potential for their respective technologies.

“We are excited to join forces with Emoviar to unlock new possibilities in drug delivery and beyond”.
“Cyclodextrins have vast potential in pharmaceutical applications, and together, we can create cutting-edge solutions.”

For more information, please contact:
tamas.sohajda@carbohyde.com

Visiting the “in-laws”

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Gergely Toth and Tamas Kiss, participate at Health Tech Hub Styria (HTH) – Pitch & Partner 2025 in Graz establishing new connections with companies from our western neighbor.

The event aims to strengthen the connection between industry and academia and showcase early-stage innovations. It is also an excellent opportunity to find project partners, discuss future collaborations, and exchange experiences.

We appreciate the support of HEPA Hungarian Export Promotion Agency .

About the event: Health Tech Hub Styria 2025 – Home

Our CEO will be an invited speaker at Hacettepe University

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I am thrilled to accept the invitation of Prof. Erem Bilensoy to deliver a talk at Hacettepe University about the pharma uses of cyclodextrins.

The department’s 2024-25 Spring Semester Seminars will be held between March 26, 2025 and May 28, 2025 on Wednesdays between 09:30-10:30 in the Seminar Hall of the Department of Pharmaceutical Technology. There is a free participation link for students, academicians, public employees and pharmaceutical industry members who want to follow the seminars online.

I hope many will be there and we will have a stimulating and active discussion!

Continuous Production of Bifunctional Platform Chemicals From Plant Oils in Water by Cyclodextrin-Mediated Hydroformylation

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today’s cyclodextrin:
CDs supporting the synthesis of renewable chemicals

Cyclodextrin-mediated aqueous biphasic systems are a potent way to recycle homogeneous catalysts, also applicable to producing highly demanded renewable chemical intermediates.

Thomas Seidensticker and his team from TU Dortmund University present the Rh-catalyzed, cyclodextrin-mediated, aqueous biphasic hydroformylation of methyl 10-undecenoate (from castor oil) and methyl 9-decenoate (from rapeseed oil) to produce methyl 12-oxododecanoate and methyl 11-oxoundecanoate, respectively, with high yields and productivity.

Cyclodextrin based artificial enzymes

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Using cyclodextrins (CDs) as scaffolds for artificial enzymes has emerged as a promising strategy for improving catalytic processes.

CDs are still widely used in the design of artificial enzymes and in understanding the enzymatic reaction mechanisms, especially in applications that require the modification of substrate solubility or the stabilization of reaction intermediates.

This review summarizes the CD-based artificial enzyme development, discusses key challenges and limitations of syntheses, and explores potential strategies to improve their catalytic activity.

Great paper from László Jicsinszky, Katia Martina, Luisa Boffa, Giancarlo Cravotto