The first secondment at Bicyclos has been completed

Kristóf Felegyi just completed CarboHyde’s very first secondment under the scope of the Bicyclos HEurope project under the strong support of Csenge Anna Felegyi-Tóth.

Kristof worked for 5 months in the lab of Jose Manuel Garcia Fernandez under the supervision of Juanma Benito and created various cyclodextrin polymers that we will evaluate for gene and small molecule delivery.
😎
We appreciate the strong support and hospitality of CSIC and look forward to further collaborations.

As Kristof did not take a single photo in the lab, we can only trust he did not only do sightseeing in the wonderful city

Kristof Felegyi, Bicyclos, CarboHyde, Seville

CarboHyde CEO Tamas Sohajda Presents at CPHI NA on Novel Uses of Cyclodextrins in the Pharmaceutical Industry

CarboHyde CEO Tamas Sohajda recently delivered a compelling presentation at the CPHI North America conference, focusing on innovative applications of cyclodextrins in the pharmaceutical industry. His talk highlighted how these unique cyclic oligosaccharides can enhance drug delivery, improve solubility, and stabilize formulations, offering significant benefits to pharmaceutical development.

Cyclodextrins, known for their ability to form inclusion complexes with various molecules, have been extensively studied for their potential to revolutionize drug formulations. Sohajda’s presentation delved into recent advancements and case studies demonstrating the successful integration of cyclodextrins in new drug delivery systems. These developments promise to improve the efficacy and safety of numerous medications, addressing longstanding challenges in drug formulation and bioavailability.

The talk received considerable attention from industry professionals, underscoring CarboHyde’s leading role in pioneering the use of cyclodextrins for pharmaceutical innovation. Attendees had the opportunity to engage with Sohajda, discussing cyclodextrin research’s practical applications and future directions.

A video of the event is available on CPHI website – after a registration – for those who missed the presentation or wish to revisit the insights shared.

CPHI: Lightning Round: Excipients 4.0 – Cyclodextrins (CDs) (video) (cphi-online.com)

On Vimeo:

Dr Tamas Sohajda Lightning Round Excipients 4.0 – Cyclodextrins CDs on Vimeo

Stay tuned for more updates from CarboHyde as they continue to push the boundaries of pharmaceutical technology.

GENEGUT meeting in Porto

Today’s #yclodextrin is about the fantastic progression of the GENEGUT project CarboHyde is part of.

The 5th in-person General Assembly meeting was kindly hosted by our partners at i3S – Instituto de Investigação e Inovação em SaúdeBruno SarmentoCatarina Leite Pereira in Porto, PT 🚀

We (Kristóf Felegyi) reported the chemistry work, which was our part, and now look forward to seeing how these building blocks will perform in RNA delivery and eventually in drug formulation. Caitriona O’Driscoll and Ana Francisca Soares presented some of the promising data at the 21st International Cyclodextrin Symposium last week.

We look forward to interesting discussions, progress updates and networking within the GENEGUT consortium 💡

GENEGUT, Porto, Horizon EUrope

Few days to go until 21st International Cyclodextrin Symposium

In a few days the global cyclodextrin community gathers in Dunkerque to share thoughts, and results, discuss collaborations and renew friendships.

From CarboHyde‘s perspective, there are several lectures that we look forward to with great excitement:

  1. Francesco Stellacci – our long time collaborator from EPFL , pioneer of using cyclodextrins as antiviral compounds, founder of asterivir
  2. Matthew “Oki” O’Connor – CEO of Cyclarity Therapeutics , a close partner of us doing groundbreaking science of using CDs in atherosclerosis
  3. Tamas Sohajda – CarboHyde CEO delivers a review on using cyclodextrins as active ingredients
  4. Julien Parcq & Damien TRUFFIN – from Roquette, our key partner in cyclodextrin education, discussing critical attributes of CD manufacturing & safety
  5. Milo Malanga PhD – CarboHyde CSO sharing from synthetic challenges
  6. Juan Manuel Benito – Bicyclos HEurope partner, expert in using CDs for gene delivery
  7. Caitriona O’DriscollGENEGUT coordinator, an expert in using CDs for gene delivery
  8. Francesco Trotta & Adrián Matencio Durán, our research partners on nanosponges from University of Turin
  9. Szabolcs Béni – from CarboHyde advisory board and BiCyclos member from Eötvös Loránd University, an expert on CD NMR and analysis
  10. Ilse Manet – BiCyclos coordinator, an expert in CD analysis and applications

And this is just the tip of the iceberg.

21st International Cyclodextrin Symposium, Carbohyde

Our CEO, Tamas Sohajda, presented at CPhI North America

Here are a few words from Tamás about the conference:

A few weeks ago at CPHI North America, I had the pleasure of helping the audience peek into the future of cyclodextrins by showcasing some of the applications we are working on at CarboHyde such as:
– therapeutic cyclodextrins and their development
– using cyclodextrins in vaccines
– using cyclodextrins for gene delivery

I had never spoken at CPHI before, yet it was a fascinating experience, mainly due to James Reidy’s fantastic support.

CarboHyde – Cyclodextrin live Q&A

Join us for an exclusive LinkedIn Live event as we dive into the intriguing world of cyclodextrins! This dynamic Q&A session features industry experts, researchers, and enthusiasts exploring the diverse applications and cutting-edge advancements in cyclodextrin science.

📅 Date & Time: June 5, 2024, 16:00 CET

📍 Location: LinkedIn Live – Event Link

What to Expect:

  • Expert Insights: Learn about cyclodextrins and their diverse applications.
  • Interactive Q&A: Ask your questions and get real-time answers from experts.
  • Networking: Connect with professionals and researchers in the field.

How to Participate:

  1. Follow our LinkedIn page for updates.
  2. Set a reminder for the event.
  3. Prepare your questions for the Q&A session.

Who Should Attend:

  • Researchers, scientists, and professionals in relevant industries.
  • Students and academics interested in cyclodextrin advancements.

Don’t miss this chance to engage with experts and enthusiasts in cyclodextrin science!

Join us and ask your questions directly to our CEO, Tamas Sohajda.

Register and learn more here: Event Link

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers

Fresh from the oven, is a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.

Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.

Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers | ACS Medicinal Chemistry Letters

Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.

Bicyclos project runs at full speed

In the past weeks, we have had the pleasure of welcoming Ilse Manet, the leader of the Bicyclos consortium, to our lab and city. We discussed the progress of the staff exchange program, the science we are doing—results obtained, experiments planned—and the fine details of the workshop we organized together in September in Budapest.