Apparently, cyclodextrin-based oligonucleotide delivery is becoming a hot research topic. This recent study from University of Nova Gorica – Tina Škorjanc, PhD, Damjan Makuc, Nora Kulak, and Valant Matjaz presents a cyclodextrin porous polymer to form nanometer-sized particles and used as a delivery vehicle for metal-free and Cu(II)-metalated anthraquinone-based DNA intercalators.
Today’s cyclodextrin is a smart and very practical study, highlighting how different cyclodextrins added to a liposomal formulation could influence the release of the active load.
The results demonstrated that the CDs effect on the membrane depends on the CD type, CD concentration, and membrane cholesterol content. The investigated CDs exhibited an instantaneous permeabilizing effect promoting vesicle leakage of API from the various membranes; this effect increased with CDs concentration. Among the studied CDs, α-CD, β-CD, and RAMEB were the most permeabilizing CDs on the different membranes.
Ghenwa Nasr, Helene Greige, Sophie Fourmentin, Abdelhamid ELAISSARI, Nathalie Khreich
today’s cyclodextrin: Cyclodextrin-supported sensors on the way!
While hydrogels enable a variety of applications in wearable sensors and electronic skins, they are susceptible to fatigue fracture during cyclic deformations owing to their inefficient fatigue resistance. Herein, acrylated β-cyclodextrin with bile acid is self-assembled into a polymerizable pseudorotaxane via precise host-guest recognition, which is photopolymerized with acrylamide to obtain conductive polymerizable rotaxane hydrogels (PR-Gel). The topological networks of PR-Gel enable all desirable properties in this system due to the large conformational freedom of the mobile junctions, including the excellent stretchability along with superior fatigue resistance. PR-Gel based strain sensor can sensitively detect and distinguish large body motions and subtle muscle movements. The three-dimensional printing fabricated sensors of PR-Gel exhibit high resolution and altitude complexity, and real-time human electrocardiogram signals are detected with high repeating stability. PR-Gel can self-heal in air, and has highly repeatable adhesion to human skin, demonstrating its great potential in wearable sensors.
The UniLectin portal was designed in 2019 with the goal of centralising curated and predicted data on carbohydrate-binding proteins known as lectins. UniLectin is also intended as a support for the study of lectomes (full lectin set) of organisms or tissues.
Check out the most recent update by Anne Imberty, Frederique Lisacek and colleagues:
HumanLectome, an update of UniLectin for the annotation and prediction of human lectins | Nucleic Acids Research | Oxford Academic (oup.com)
today’s cyclodextrin:
Is a nice reivew by Sophie Fourmentin et al on applicatations for biopesticides.
The application of biopesticides can be challenging because they are generally insoluble in aqueous phases, highly volatile and unstable. One strategy to promote their use is their encapsulation into natural hosts, cyclodextrins. Encapsulation in cyclodextrins would offer many advantages such as increased solubility, lower release rates and protection against chemical and physical degradation. The paper discusses preharvest treatment and the different stages of the postharvest handling such as storage, distribution, packaging and marketing.
Cyclodextrins as molecular carriers for biopesticides: a review | SpringerLink
We believe that using cyclodextrin for targeted delivery of molecules is certainly one of the applications that will be in future’s research focus.
In this patent that we bring today as a good example, a camptothecin derivative and cyclodextrin polyrotaxane are subjected to a click chemical reaction under the catalysis of copper, and the cyclodextrin supramolecular drug for targeted delivery of camptothecin is obtained by using active folate termination. Cell experiments show that the compound has good targeting selectivity and anti-tumor effect, and also has the advantage of small toxic and side effects.
Today’s cyclodextrin:
Did you know that CDs can be used even in the construction industry? There are many applications, one is reducing water in concrete.
Here, a modified beta-cyclodextrin polycarboxylic acid water reducing agent, an anti-mildew antibacterial agent, sodium lignin sulfonate, sodium dodecyl benzene sulfonate, a polyether defoaming agent, sodium tripolyphosphate, triisopropanolamine, sodium nitrite, ethylene glycol and water to obtain the concrete water reducing agent. The concrete water reducer prepared is excellent in slump retaining performance and water reducing performance, and good in storage stability.
Another great application using cyclodextrin in non-viral drug delivery for gene therapy is presented in this paper underlining the versatility of these compounds in this field – similar in application to what we are working on in GENEGUT.
Colleagues present a novel targeting bio-conjugate for selective delivery of therapeutic nucleic acids, including RNA oligonucleotides and DNA- oligonucleotides, preferably gene-encoding DNA plasmids or minicircle DNAs, to eukaryotic cells by means of receptor-mediated endocytosis and endosomal release.
Dietmar Appelhans et al.
As women continue to return to the workforce following a decline during the Covid pandemic, many companies know that to attract top female talent they need to offer benefits like family leave options as well as other opportunities for women’s empowerment on the job. For Forbes’ ranking of the World’s Top Companies for Women 2023, we looked at the companies that are excelling in these areas. Check out the list below, and then keep reading for stories on “energy vampires” at the office, bridge jobs and more.
World’s Top Companies for Women 2023 (forbes.com)
Today’s cyclodextrin:
Improving antibacterial drugs’ physicochemical characteristics and biological activities has been in the focus of CD research for a long time. This extensive review by deals with this topic showing the biological results rvealing the antibacterial effect of the inclusion complexes was extensively improved. Cyclodextrins can enhance the therapeutic effects of antibiotics already existing on the market, natural products and synthetic molecules. Overall, CDs as drug-delivery vehicles have been shown to improve antibiotics solubility, stability, and bioavailability, leading to enhanced antibacterial activity.
