Synthesis, binding affinity, and inhibitory capacity of cyclodextrin-based multivalent glycan ligands for human galectin-3

Bathing in carbs: Lai-Xi Wang and his group from the University of Maryland reported the synthesis of cyclodextrin-based multivalent glycan ligands for human galectin-3. The GalNAc (Tn antigen) containing heptavalent ligand showed the highest affinity for human Gal-3 among the synthetic ligands tested, with an EC50 of 1.4 μM in binding to human Gal-3.

Link to the article

carbohyde, galectin, cyclodextrin

Identification of a βCD-Based Hyper-Branched Negatively Charged Polymer as HSV-2 and RSV Inhibitor

Cyclodextrin derivatives were demonstrated to be endowed with intrinsic antiviral action against several viruses (herpes, HIV, RSV, influenza, covid19, etc.). In this great work from Rachele FranceseFrancesco TrottaClaudio Cecone, Matteo Constantino, Gjylije Hoti, Pierangiola Bracco, and David Lembo from the University of Turin, four water-soluble hyper-branched beta cyclodextrin anionic polymer were screened against herpes simplex virus (HSV-2), respiratory syncytial virus (RSV), rotavirus (HRoV), and influenza virus (FluVA). The results suggest that the polymer virucidal activity against RSV can be exploited to produce new antiviral materials to counteract the virus dissemination through the air or direct contact.

cyclodextrin,carbohyde, blog,

Methods for treatment of familiar heterozygous and homozygous hypercholesterolemia with cyclodextrins

Using cyclodextrins, especially 2-hydroxypropyl-beta-CD for the treatment of atherosclerosis has a hype, there are several companies and research groups chasing this holy grail. Fresh from the oven is the patent application from Beren Therapeutics explaining methods of treating familial hypercholesterolemia via different mechanisms of action.

More in the original patent

atherosclerosis, cyclodextrin, carbohyde