influenza - CarboHyde

Development of Broad-spectrum β-cyclodextrins-Based Nanomaterials Against Influenza Viruses

Apr 15, 2024Tamas Sohajdacarbohydratesantiviral, cyclodextrin, influenza, nanotechnology

Cyclodextrins as antivirals? Why not?

Caroline Tapparel Vu, Francesco Stellacci and colleagues from EPFL and University of Geneva created a groundbreaking molecule, CD-SA, that mimics flu virus receptors to fight off multiple influenza strains effectively! 🦠💥 Our studies show CD-SA outperforms existing treatments like Oseltamivir, offering a new hope against flu with fewer chances of resistance when coupled with IFN λ1. Exciting results from lab to mice models prove its potent antiviral powers! 🚀🔬

Development of Broad-spectrum β-cyclodextrins-Based Nanomaterials Against Influenza Viruses | bioRxiv

Asterivir develops CD-based broad-spectrum antiviral

Dec 9, 2022Tamas SohajdaToday's cyclodextrincovid19, drug development, influenza, rsv

New kid on the block: Asterivir’s website has just gone live. Asterivir – a spinout from EPFL (École Polytechnique fédérale de Lausanne) – develops CD-based broad spectrum antivirals lead by Francesco Stellacci, Paulo Jacob Silva and Oscar Buset. The initial findings of the company were published earlier (Caroline Tapparel Vu et al. )
The website contains nice video graphics of the mechanism of action, which is worth checking!

See the website here

Identification of a βCD-Based Hyper-Branched Negatively Charged Polymer as HSV-2 and RSV Inhibitor

Sep 21, 2022Tamas SohajdaEgyéb kategóriaantiviral, covid19, HIV, influenza

Cyclodextrin derivatives were demonstrated to be endowed with intrinsic antiviral action against several viruses (herpes, HIV, RSV, influenza, covid19, etc.). In this great work from Rachele Francese, Francesco Trotta, Claudio Cecone, Matteo Constantino, Gjylije Hoti, Pierangiola Bracco, and David Lembo from the University of Turin, four water-soluble hyper-branched beta cyclodextrin anionic polymer were screened against herpes simplex virus (HSV-2), respiratory syncytial virus (RSV), rotavirus (HRoV), and influenza virus (FluVA). The results suggest that the polymer virucidal activity against RSV can be exploited to produce new antiviral materials to counteract the virus dissemination through the air or direct contact.