Cyclodextrin based artificial enzymes

Using cyclodextrins (CDs) as scaffolds for artificial enzymes has emerged as a promising strategy for improving catalytic processes.

CDs are still widely used in the design of artificial enzymes and in understanding the enzymatic reaction mechanisms, especially in applications that require the modification of substrate solubility or the stabilization of reaction intermediates.

This review summarizes the CD-based artificial enzyme development, discusses key challenges and limitations of syntheses, and explores potential strategies to improve their catalytic activity.

Great paper from László Jicsinszky, Katia Martina, Luisa Boffa, Giancarlo Cravotto

InnoChem-25 Conference

I am happy to contribute to this fascinating upcoming event!

Join the International Conference on Recent Breakthroughs in Chemical Sciences (InnoChem-25) organized by the School of Sciences, Woxsen University.

🔬 Theme: Innovations in Chemistry for Sustainable Solutions

📅 April 8-11, 2025
🌐 Fully Online Conference

Featuring distinguished plenary speakers:
– Dr. Joe Wang (University of California San Diego, USA)
– Prof. Kara Bren (University of Rochester, USA)
– Dr. Tamas Sohajda (CarboHyde, Hungary)
– Dr. Tapas Sen, PhD, FRSC, FHEA, FRSM (University of Central Lancashire, UK)

Plus an impressive lineup of keynote speakers from renowned institutions worldwide, including experts from ICT Mumbai, IIT Hyderabad, Czech Republic, Nigeria, and more!

Perfect opportunity for:
• Chemical scientists
• Researchers
• Industry professionals
• Academia

Register now: REGISTRATION FEE ONLINE

Cyclodextrin Tales: Celebrating 100 Issues

Actually, it’s 103 already.

I started writing this newsletter on the 23rd January, 2023.

In the ever-evolving world of science, staying updated on the latest research of cyclodextrins can be a challenge. Cyclodextrin Tales, a LinkedIn-based scientific newsletter, has been bridging that gap by providing insightful articles on cyclodextrins—fascinating ring-shaped molecules with applications in pharmaceuticals, food, and beyond. Now, with its 100th issue, the blog has firmly established itself as a go-to resource for scientists, researchers, and industry professionals alike.

Launched to bring awareness and discussion around cyclodextrins, Cyclodextrin Tales has consistently delivered high-quality, engaging content. Each issue dives into a different aspect of these versatile molecules, from their role in drug delivery and environmental applications to emerging innovations in material science. The blog’s ability to break down complex scientific concepts into accessible insights has made it an essential read for both experts and newcomers to the field.

If you like these brief communications, Subscribe to join 4500 cyclodextrin enthusiasts, and gain and share knowledge on current and novel applications, challenges, and possibilities.

Beyond just being informative, Cyclodextrin Tales has cultivated a growing community of professionals who share a passion for these intriguing molecules, counting now 4500+ subscribers. Discussions sparked by each issue have led to collaborations, knowledge exchange, and deeper engagement within the scientific world. By reaching this 100th issue milestone, the blog not only marks a numerical achievement but also highlights the sustained curiosity and innovation surrounding cyclodextrins.

As Cyclodextrin Tales looks ahead to the future, it remains a valuable hub for scientific exploration. With new research constantly emerging, the blog is set to continue its mission of educating, inspiring, and connecting people in the world of cyclodextrins. Here’s to the next 100 issues and beyond!

Some of my favorite issues?

Size Matters: How Cyclodextrin Cavity Size Impacts its Applications

CarboHydrate Chronicles – the podcast to meet cyclodextrin experts

Exploring the Visionary Role: Ophthalmic Uses of Cyclodextrins

Beyond the Doughnut: Cyclodextrins as Nanoparticles in Cutting-Edge Innovations

The Story Behind Sugammadex’s Success

Stabilized Nucleic Acid Processing for Enhanced Amplification

today’s cyclodextrin:
I love this invention from Biomeme, Inc. for processing a target nucleic acid sequence.

The inventors – Jonathan H. & Stephen Judice – use cyclodextrin to stabilize an enzyme and nucleic acids.
CDs can also shorten a cycle threshold value or a time to result value in the nucleic acid amplification and lower a detection limit.

Read the patent here: WO2025049920 METHODS AND COMPOSITIONS FOR SAMPLE PROCESSING

carbohyde

CarboHyde Cyclodextrin Masterclass IV

What to Expect?
Explore the evolving landscape of cyclodextrin-based drug delivery, from established uses to groundbreaking innovations. Our expert speaker will dissect key advancements, addressing both challenges and transformative opportunities that enhance therapeutic efficacy.

Key Focus Areas:
Monoclonal Antibodies
Gene Therapy
Vaccines
Biotechnology

You can register here: Cyclodextrin Masterclass IV – CarboHyde

Polycationic γ-Cyclodextrin with Amino Side Chains for a Highly Efficient Anti-Heparin Coagulant

Today’s cyclodextrin is and Anti-Heparin Coagulant

Yes, you got it right.

From the development of Alveron Pharma, we already know it works.

This study reports an aminoethoxy-phenyl-pyridinium-modified γ-cyclodextrin (PyA-γ-CD) as a highly efficient coagulant for heparin through multivalent interactions.

PyA-γ-CD not only exhibits nearly complete neutralization activity for unfractionated heparin (UFH), but more importantly, it also effectively neutralizes three LMWHs (dalteparin (Dalte), enoxaparin (Enoxa), and nadroparin (Nadro)) with a broader therapeutic window compared to protamine.

Polycationic γ‐Cyclodextrin with Amino Side Chains for a Highly Efficient Anti‐Heparin Coagulant – An – Advanced Healthcare Materials – Wiley Online Library

New cyclodextrin patent for agricultural application

Today’s cyclodextrin is my next cyclodextrin patent.

I have been advocating for improved solutions for agriculture formulations for a long time.

Cyclodextrins can help improve the biological activity and uptake of pesticides and insecticides, improve their penetration, reduce their applied dose (and burden on the environment) and even achieve controlled release of these agents.

US20250057161 USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM


This is what our patent with ADAMA Ltd. is about.
Shimon Amselem, Lital Koren, Zoltán Fülöp, István Puskás

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential

Hungarian cyclodextrin science flourishes!

This paper by Horváti Kata & Chiara Bellini et al is about formulating lipopeptides.

Formulation with the randomly methylated α-cyclodextrin (RAMEA) and the sulfobutylether-β-cyclodextrin (SBECD) has resulted in the production of ultralow-sized molecular dispersion systems and reduced lipopeptide toxicity without compromising its antimicrobial activity.

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential – Bellini – Aggregate – Wiley Online Library