Carbohyde Welcomes French Students from Strasbourg for an Insightful Visit

We are thrilled to express our gratitude for the recent visit from a group of bright students from University of Strasbourg to Carbohyde. The enthusiasm and curiosity displayed by the students were truly inspiring.

During their visit, the students engaged in meaningful discussions, asking insightful questions about our research and development activities. It was a pleasure to witness their passion for science and witness the curiosity that drives the next generation of scientists.

At Carbohyde, we are committed to fostering an environment that encourages learning and collaboration. Hosting such dynamic groups of students aligns with our mission to inspire and contribute to the future of pharmaceutical research. We extend our heartfelt thanks to the students from Strasbourg for their keen interest and look forward to more opportunities to share our knowledge and experiences with the scientific community.

Acute Effects of 30 g Cyclodextrin Intake during CrossFit® Training on Performance and Fatigue

Today’s cyclodextrin:
Ready for some weekend workout? Have you planned to take some cyclodextrin afterward?
This study by Ismael Martínez Guardado and colleagues looks into the effect of taking 30 g cyclodextrin (Cluster Dextrin® – which is not clear to me what kind of cyclodextrin is, if any) during CrossFit Training on Performance and Fatigue. Although some differences were found, supplementation with 30 g of cyclodextrin did not have any metabolic or performance effects in CrossFit tests.

JFMK | Free Full-Text | Acute Effects of 30 g Cyclodextrin Intake during CrossFit® Training on Performance and Fatigue (mdpi.com)

Educational material on cyclodextrins is available

In the past few years, we have created dozens of educational materials on various uses of cyclodextrin, such as complex preparation, monoclonal antibody formulation, uses in vaccines, gene therapy, and various non-pharma applications.

We collected these decks for you in two easy-to-digest platforms.

Here you can find (and download) the decks: https://www.carbohydesolutions.com/natures-gift-for-mankind-are-cyclodextrins/

On our YouTube channel, you can watch them as short videos:

https://www.youtube.com/@CarboHyde

Learn and enjoy!

Using cyclodextrins in the textile industry

today’s cyclodextrin:
I brought some applications from the textile industry. Interestingly, there are no real successful commercial examples (that I know of, at least) using CDs in the textile industry. Yet there are so many inventions in the field, I am sure, this is just a matter of time. These two applications are both interesting, on is and ultraviolet-resistant application, the other is a flame-retardant material.

Flame-retardant non-woven fabric and preparation process

Anti-ultraviolet multifunctional textile fiber material and preparation method thereof

Adamgammadex vs Sugammadex

Check out this fascinatnig discussion on next future of cyclodextrin-based antidotes and scavengers by J Robert Sneyd adn Jennifer Hunter.

Spoiler alert: Phase 3 clinical trials suggest that Adamgammadex is slightly less potent than sugammadex and has a non-inferior speed of onset. In a multicentre trial of 310 patients, there was a suggestion of a lower incidence of allergic responses and recurarisation after adamgammadex compared with sugammadex.

If you are also thinking about creating a special cyclodextrin like that, this may be useful for you: Custom synthesis of cyclodextrins – www.carbohydesolutions.com

Is adamgammadex the brother of sugammadex or the next generation of reversal agent? – British Journal of Anaesthesia (bjanaesthesia.org)

Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate

Today’s cyclodextrin:
One of the greatest features of CDs is that with a proper application (especially when the local CD concentration is relatively high), they can not only improve the solubility but also the permeability of compounds. For example, in the case of a peroral application, let’s say an orally disintegrating tablet. Not to mention that their taste masking potential is also of use in this case. 3 birds with one stone!

In this paper, you can find a great example of such a smart application. If you are interested in developing similar formulations, check out the first steps here: Formulation development – www.carbohydesolutions.com

Pharmaceutics | Free Full-Text | Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate (mdpi.com)

Bicyclos starting!

As we reported earlier CarboHyde is part of an EU-sponsored 4-year long staff-exhange project, Bicyclos.

Bicyclos is a staff exchange project funded by the Horizon Europe Framework Programme after successful application in the call HORIZON-MSCA-2022-SE-01-01. The project started on September 1st, 2023. We are 9 beneficiaries and 2 associated partners coming from 8 countries in Europe and America. We are all interested in fostering progress of cyclodextrins in biomedical applications.

During this project, CarboHyde staff will spend 30+ months abroad and will host students for 40+ months in the upcoming 4 years doing high level science on moonshot projects – of course, all based on cyclodextrins.

Now its time to start our first journey, as our excellent chemist, Kristóf Felegyi is going to Seville for 5 months to make some fancy compounds at the lab of Jose Manuel Garcia Fernandez.

Farewell Kristof, we expect you back soon!

Washable ink composition

Today’s cyclodextrin is another industrial application, now from the material sciences: a washable ink!
The cyclodextrin is said to be included to improve the washability and vividness of the shades of a washable aqueous ink composition. According to the patent, in this particular application HPBCD is used, yet I think that would be more composition dependent.

Link to patent: https://worldwide.espacenet.com/publicationDetails/claims?CC=US&NR=2023383132A1&KC=A1&FT=D&ND=&date=20231130&DB=EPODOC&locale=en_EP