Exploring the Efficacy of Methylated Gamma-Cyclodextrin (M-γ-CD) in the Removal of Heavy Metals in Soil Systems

Today's cyclodextrin, ,

Today’s cyclodextrin is about the Removal of Heavy Metals in Soil Systems

This review provides a comprehensive overview of environmental remediation strategies using cyclodextrin and examines the effectiveness of methylated gamma-cyclodextrin (M-γ-CD) for the elimination of toxic elements from impure soil matrices.

M-γ-CD has emerged as a potent agent for treating soil impurities with noxious metals forming inclusion complexes with heavy-metal ions, thereby cumulating the aqueous solubility and efficiency of pollutants in environmental applications and improving soil bioremediation.

Dr Nontobeko Gloria Maphuhla and Dr OpeOluwa Oyedeji

Exploring the Efficacy of Methylated Gamma-Cyclodextrin (M-γ-CD) in the Removal of Heavy Metals in Soil Systems

Opening new doors in the cosmetic industry

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At CarboHyde we really believe that cyclodextrins have much more to offer beyond the pharma industry and are testing the waters in new areas, like cosmetic applications.

We have a number of development projects in the area that we will share in the coming weeks.

In the meantime, you can meet Dani at Cosmoprof Worldwide Bologna if you wish to discuss how cyclodextrins are and can be used in cosmetics.

And also in daily training, 20 km walking is quite a leg-day 🙂

A unique two-excipient heat stable tablet formulation of oral insulin: preliminary results

Today's cyclodextrin,

Today’s cyclodextrin is about stabilizing insulin.

Using freeze drying to form a heat-stable tablet in a single-step process, hydroxypropyl beta cyclodextrin (HP-β-CD) encapsulated lipophilic ion-pair complex of insulin using bile salt achieves demonstrated intestinal absorption and sustained glucose levels.

The tablets produced using this simple approach with only two excipients offer protection from enzymatic and stomach acid degradation and facilitate insulin uptake, without any need for specialized drug manufacturing or enteric coating.

The convenient presentation of insulin as a thermostable oral tablet presents a low-cost scalable manufacturing method that simplifies the logistics of storage, transport, and distribution in any setting, including areas where cold storage maybe limited or unavailable.


Read the full paper from Manshun Lai, Changcheng Zhu, Jaclyn Delarosa, and Manjari Lal PhD here: A unique two-excipient heat stable tablet formulation of oral insulin: preliminary results | bioRxiv

CarboHyde and Emoviar PharmaCon GmbH Announce Strategic Collaboration in Sustained Release Technology

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CarboHyde Zrt, a leader in cyclodextrin research and development, has entered into a strategic collaboration with Emoviar PharmaCon GmbH, a specialist in sustained release technologies.

This partnership aims to explore new business opportunities by leveraging CarboHyde’s expertise in cyclodextrins and Emoviar’s advanced sustained release formulations.

Through this collaboration, both companies will work together to identify and develop innovative applications, expanding market potential for their respective technologies.

“We are excited to join forces with Emoviar to unlock new possibilities in drug delivery and beyond”.
“Cyclodextrins have vast potential in pharmaceutical applications, and together, we can create cutting-edge solutions.”

For more information, please contact:
tamas.sohajda@carbohyde.com

Visiting the “in-laws”

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Gergely Toth and Tamas Kiss, participate at Health Tech Hub Styria (HTH) – Pitch & Partner 2025 in Graz establishing new connections with companies from our western neighbor.

The event aims to strengthen the connection between industry and academia and showcase early-stage innovations. It is also an excellent opportunity to find project partners, discuss future collaborations, and exchange experiences.

We appreciate the support of HEPA Hungarian Export Promotion Agency .

About the event: Health Tech Hub Styria 2025 – Home

Our CEO will be an invited speaker at Hacettepe University

carbohydrates, news, ,

I am thrilled to accept the invitation of Prof. Erem Bilensoy to deliver a talk at Hacettepe University about the pharma uses of cyclodextrins.

The department’s 2024-25 Spring Semester Seminars will be held between March 26, 2025 and May 28, 2025 on Wednesdays between 09:30-10:30 in the Seminar Hall of the Department of Pharmaceutical Technology. There is a free participation link for students, academicians, public employees and pharmaceutical industry members who want to follow the seminars online.

I hope many will be there and we will have a stimulating and active discussion!

Continuous Production of Bifunctional Platform Chemicals From Plant Oils in Water by Cyclodextrin-Mediated Hydroformylation

Today's cyclodextrin,

today’s cyclodextrin:
CDs supporting the synthesis of renewable chemicals

Cyclodextrin-mediated aqueous biphasic systems are a potent way to recycle homogeneous catalysts, also applicable to producing highly demanded renewable chemical intermediates.

Thomas Seidensticker and his team from TU Dortmund University present the Rh-catalyzed, cyclodextrin-mediated, aqueous biphasic hydroformylation of methyl 10-undecenoate (from castor oil) and methyl 9-decenoate (from rapeseed oil) to produce methyl 12-oxododecanoate and methyl 11-oxoundecanoate, respectively, with high yields and productivity.

Cyclodextrin based artificial enzymes

Today's cyclodextrin,

Using cyclodextrins (CDs) as scaffolds for artificial enzymes has emerged as a promising strategy for improving catalytic processes.

CDs are still widely used in the design of artificial enzymes and in understanding the enzymatic reaction mechanisms, especially in applications that require the modification of substrate solubility or the stabilization of reaction intermediates.

This review summarizes the CD-based artificial enzyme development, discusses key challenges and limitations of syntheses, and explores potential strategies to improve their catalytic activity.

Great paper from László Jicsinszky, Katia Martina, Luisa Boffa, Giancarlo Cravotto