alzheimers - CarboHyde

Cyclo Therapeutics Announces First Patient Dosed in Phase 2b Study of Trappsol® Cyclo™ for the Treatment of Early Alzheimer’s Disease

Jan 10, 2023Tamas Sohajdacarbohydratesalzheimers, cholesterol, clinical trial, neurodegenerative diseases, rare disease

Cyclo Therapeutics, Inc. announces first patient dosed in Phase 2b study of Trappsol® Cyclo™ for treating early Alzheimer’s disease.

Trappsol® Cyclo™ is the Company’s proprietary formulation of hydroxypropyl beta-cyclodextrin. In multiple clinical studies, it has shown encouraging results in effectively managing the transportation of cholesterol, a known defect in neurodegenerative diseases. Many known risk factors for Alzheimer’s disease are associated with cholesterol metabolism.

Cyclo Therapeutics is currently testing the same investigational Trappsol® Cyclo™ drug in Phase 3 clinical trial (TransportNPC™) and a long-term extension study for the treatment of Niemann-Pick disease Type C1, a rare, fatal, and progressive genetic disorder. Taking the place of the defective NPC1 protein, Trappsol® Cyclo™, with its cyclic structure, facilitates the transport of accumulated cholesterol out of cellular lysosomes so it can be further processed and excreted out of cells. With the biological similarities demonstrated between Niemann-Pick disease Type C1 and Alzheimer’s disease, including cholesterol accumulation in regions of the brain, elevated levels of Tau in cerebrospinal fluid (“CSF”), and amyloid plaques in the brain, the Company believes Trappsol® Cyclo™ has significant potential to be an effective treatment option for Alzheimer’s disease.

Read the full announcement here

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Dec 6, 2022Tamas Sohajdacarbohydratesalzheimers, cholesterol

Understanding the mechanism of action is crucial in order to develop truly efficient cyclodextrin-based actives. Massachusetts Institute of Technology’s study on Alzheimer’s disease reveals correlations between APOE4, cholesterol transport, and therapeutic opportunities for CDs.
Important study Joel Blanchard, Li-Huei Tsai et al.

See the full article on nature.com

Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells

Nov 16, 2022Tamas Sohajdadrug developmentalzheimers, brain research, neurodegenerative diseases, rare disease

Heartwarming to see such important findings published by Hungarian researchers on the effects of Hydroxypropyl-beta-cyclodextrin on Cultured Brain Endothelial Cells. Cytotoxicity, permeability, and cellular internalization of HPBCD on primary rat and immortalized human (hCMEC/D3) brain capillary endothelial cells were investigated, which can help to develop new strategies for improved HPBCD effects after systemic administration.

See the full article

New clinical trial upcoming using cyclodextrin as active

Nov 11, 2022Tamas Sohajdacarbohydratesalzheimers, clinical trial, fda, neurodegenerative diseases

Cyclo Therapeutics, Inc. sponsors Phase II trial for early Alzheimer’s disease. The study will enroll approximately 90 male and female patients aged 50 to 80 years who will be given a minimum active dose of 500 mg/kg of Trappsol Cyclo (equivalent to 18,500 mg/m2) as an intravenous (IV) infusion once every 28 days for 6 months.
We wish the best of success to our colleagues at Cyclo Therapeutics and hope this therapy will prove useful for the benefit of these patients.
Having programs ourselves in developing NCEs for neurodegenerative diseases, we find this study particularly essential.