Having an interest in the applications of novel carbohydrates in neurodegenerative diseases, we applaud this paper on the aggregation of Tau fragments in the presence of different cosolutes, including urea, TMAO, sucrose, and 2-hydroxypropyl-β-cyclodextrin (2-HPβCD).
The intrinsically disordered protein Tau represents the main component of neurofibrillary tangles that are a hallmark of Alzheimer’s disease and is considered to be important for the formation of the β-structure core of the fibrils.
The remarkable ability of HPβCD to inhibit aggregation represents an extremely promising result for future applications, especially considering the widespread use of this molecule as a drug carrier to the brain and as a solubilizer/excipient in pharmaceutical formulations.
Andrea Arsiccio, Xikun Liu, Pritam Ganguly, Steve Buratto, Michael Bowers, and Joan-Emma Shea
See the full article here: Effect of Cosolutes on the Aggregation of a Tau Fragment: A Combined Experimental and Simulation Approach