Co-Delivery of 8-Hydroxyquinoline Glycoconjugates and Doxorubicin by Supramolecular Hydrogel Based on α-Cyclodextrin and pH-Responsive Micelles for Enhanced Tumor Treatment

drug delivery, ,

Two birds with one stone:
This study of the Silesian University of Technology and the Polish Academy of Sciences is close to our hearts as we both deal with glycoconjugates and cyclodextrin. They show the delivery of 8-Hydroxyquinoline Glycoconjugates and Doxorubicin using ACD-based hydrogel for enhanced tumor treatment.

Monika D. Gabriela Pastuch Piotr Kurcok 

See the full article here

Genetically encoded chemical crosslinking of carbohydrate

carbohydrates, ,

Covalent linkages are engineered between proteins and carbohydrates under biocompatible conditions. Genetically encoding the chemical crosslinking of proteins to carbohydrates offers a solution to address the low affinity and weak strength of protein–sugar interactions.
The University of California, San Francisco – Shanshan Li, Nanxi Wang, Bingchen Yu Wei Sun Lei Wang present pure beauty!
Read the full article on nature.com

carbohydrate, carbohyde, gene encode

The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3

carbohydrates, ,

Great read on pore-forming lectin SaroL-1 punching holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3 presented by a well-known team led by Anne Imberty (Grenoble University), Winfried Römer (Université de Fribourg – Universität Freiburg) and Frederique Lisacek (University of Geneva)
Fascinating!


#carbohydrates #glycotime #cancerresearch #cancer