Templated Enzymatic Synthesis of δ-Cyclodextrin

Recently, I tried to summarize in a blog post, how CDs are made from starch. Although such technologies have been used for decades, there is room for improvement for some derivatives. Sophie Beeren, Andreas Erichsen and Günther Peters at DTU – Technical University of Denmark explore this room using bolaamphiphile templates to produce δ-CD with unprecedented yields in an enzyme-mediated dynamic combinatorial library of cyclodextrins. This technology can open a new and more efficient way to produce some native cyclodextrins. Or even derivatives

See the article here.

See the Cyclodextrin Tales: From Starch to Cyclodextrins: Understanding the Production Process

A cyclodextrin polymer as supramolecular matrix for scalable green photooxygenation of hydrophobic substrates in homogeneous phase

We are proud of the fruit of our most recent collaboration with Consiglio Nazionale delle Ricerche and Semmelweis University.

Complexation of the hydrophobic substrates within a hydrophilic cyclodextrin polymer allowed their photooxygenation in a homogeneous aqueous environment. These results hold great potential for the launch of CD polymers both as reaction vessels for green, homogeneous photocatalysis and as a drug delivery carrier of oxygen-releasing agents in tissues.

Marco Agnes, Arianna Mazza, Eszter KalydiSzabolcs BéniMilo MalangaIlse Manet

See the full article here.

Comparison of the Efficacy and Safety of Adamgammadex with Sugammadex for Reversal of Rocuronium-Induced Neuromuscular Block: Results of a Phase II Clinical Trial

The success of Sugammadex inspired several further cyclodextrin research, including the development of other antidotes and discovering “follow-up” compounds for the same indication. The most advanced candidate in this field is Adamgammadex (developed by Adamerck) with its efficacy recently compared to SGM in a Phase II trial lead by Sichuan University. Although it was used in 2-3 times higher concentrations, the previously reported adverse effects were not observed in this study, including anaphylaxis, haemorrhage, recurarization, abnormal basic vital signs, or lengthened QRS intervals and QT intervals. Adamgammadex was found to be effective for reversing rocuronium-induced neuromuscular block as sugammadex.

See the full article here

Design, Synthesis, and Characterization of Stapled Oligosaccharides

From peptides to sugars: Design, Synthesis, and Characterization of Stapled Oligosaccharides. Oligosaccharide stapling increases enzymatic stability and cell penetration, opening new opportunities for using glycans in medicinal chemistry. – Max Planck Institute Manuel Garcia RicardoEmelie Ellen Reuber, Ling Yao, José Angel Danglad-FloresMartina DelbiancoPeter Seeberger
Wonderful chemistry and insightful new possibilities.

See the full article here