today’s #cyclodextrin:
is an upcoming field: continuous manufacturing of 6-monoamino-6-monodeoxy-β-cyclodextrin developed at Budapest University of Technology and Economics by Erika Bálint, Dóra Ujj, and Gábor Benkovics
See the full article here: Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin
Recently, I tried to summarize in a blog post, how CDs are made from starch. Although such technologies have been used for decades, there is room for improvement for some derivatives. Sophie Beeren, Andreas Erichsen and Günther Peters at DTU – Technical University of Denmark explore this room using bolaamphiphile templates to produce δ-CD with unprecedented yields in an enzyme-mediated dynamic combinatorial library of cyclodextrins. This technology can open a new and more efficient way to produce some native cyclodextrins. Or even derivatives
See the Cyclodextrin Tales: From Starch to Cyclodextrins: Understanding the Production Process
We are proud of the fruit of our most recent collaboration with Consiglio Nazionale delle Ricerche and Semmelweis University.
Complexation of the hydrophobic substrates within a hydrophilic cyclodextrin polymer allowed their photooxygenation in a homogeneous aqueous environment. These results hold great potential for the launch of CD polymers both as reaction vessels for green, homogeneous photocatalysis and as a drug delivery carrier of oxygen-releasing agents in tissues.
Marco Agnes, Arianna Mazza, Eszter Kalydi, Szabolcs Béni, Milo Malanga, Ilse Manet
The success of Sugammadex inspired several further cyclodextrin research, including the development of other antidotes and discovering “follow-up” compounds for the same indication. The most advanced candidate in this field is Adamgammadex (developed by Adamerck) with its efficacy recently compared to SGM in a Phase II trial lead by Sichuan University. Although it was used in 2-3 times higher concentrations, the previously reported adverse effects were not observed in this study, including anaphylaxis, haemorrhage, recurarization, abnormal basic vital signs, or lengthened QRS intervals and QT intervals. Adamgammadex was found to be effective for reversing rocuronium-induced neuromuscular block as sugammadex.
From peptides to sugars: Design, Synthesis, and Characterization of Stapled Oligosaccharides. Oligosaccharide stapling increases enzymatic stability and cell penetration, opening new opportunities for using glycans in medicinal chemistry. – Max Planck Institute Manuel Garcia Ricardo, Emelie Ellen Reuber, Ling Yao, José Angel Danglad-Flores, Martina Delbianco, Peter Seeberger
Wonderful chemistry and insightful new possibilities.
Olivier Renaudet, David Goyard, Ángela Martín-Serrano Ortiz and Didier Boturynlick from Université Grenoble Alpes presents click chemistry to decorate synthetic multivalent scaffolds with glycans to mimic the cell surface glycocalyx and to develop applications in glycosciences.
Great reivew on glycoconjugates, their synthesis and pharmaceutical applications from Scripps Research (Sachin S. Shivatare, PhD, Vidya Shivatare and Chi-Huey Wong)
A new automated glycan synthesizer offering one-pot chemical glycosylations in the solution presented by Sir Fraser’s team from Northwestern University: Yong Wu, Yunyan Qiu, and Yuanning Feng
https://pubs.acs.org/doi/10.1021/acscentsci.2c01043
What a great day when we can celebrate Carolyn Bertozzi, a pioneer in glycochemistry, and the fathers of click reaction Barry Sharpless and Morten Meldal, whose innovation we use day-by-day in our humble research.
Thank you for your groundbreaking work that enables many and more new discoveries!
Automated solution-phase multiplicative synthesis of complex glycans enabled by preactivation-based, multi-component, one-pot glycosylation and continuous multiplying amplification published by Peking University. Wonderful!
