Fascinating breaking application of cyclodextrin polymer proposed by Noemi Bognanni, Francesco Bellia and Graziella Vecchio from Università di Catania. Based on the features of cyclodextrins, they derivatized cross-linked cyclodextrin polymers with histidine or carcinine moieties and found that amylase enzymes do not hydrolyze cyclodextrin polymers. The new polymers can form copper(II) complexes and may act as nanochelators to counteract copper(II) dyshomeostasis-related diseases. Furthermore, the copper(II) complexes show superoxide dismutase activity, similar to free carcinine and histidine complexes. The antioxidant biological activity of the copper(II) complex formed in situ may protect cells from oxidative damage related to #copper dyshomeostasis.
