β-cyclodextrin polymer as tetrodotoxins scavenger in oyster extracts

Today’s cyclodextrin is a fascinating example of how to use the scavenging capabilities of cyclodextrins to develop tools against natural toxins by Alex Fragoso’s team.

Tetrodotoxins (TTXs) are potent marine neurotoxins involved in humans’ poisoning cases after consuming some marine organisms. In this work, five insoluble cyclodextrin polymers with different chemical structures have been investigated as novel clean-up materials for oyster extracts containing TTXs.

The best recoveries have been achieved with βCDP-14-DS2 (∼100 %), which allowed exposing cells to 27-fold higher oyster matrix concentrations and decreased the LOQ down to 46 µg equiv. TTX/kg.

Then, the applicability of this strategy has been demonstrated with oyster extracts from The Netherlands and comparing the results with immunoassay and liquid chromatography-tandem mass spectrometry (LC-MS/MS). This clean-up strategy combined with CBA could be implemented for TTXs detection in monitoring programs to ensure seafood safety.

β-cyclodextrin polymer as tetrodotoxins scavenger in oyster extracts – ScienceDirect

cyclodextrin, CarboHyde

Few days to go until 21st International Cyclodextrin Symposium

In a few days the global cyclodextrin community gathers in Dunkerque to share thoughts, and results, discuss collaborations and renew friendships.

From CarboHyde‘s perspective, there are several lectures that we look forward to with great excitement:

  1. Francesco Stellacci – our long time collaborator from EPFL , pioneer of using cyclodextrins as antiviral compounds, founder of asterivir
  2. Matthew “Oki” O’Connor – CEO of Cyclarity Therapeutics , a close partner of us doing groundbreaking science of using CDs in atherosclerosis
  3. Tamas Sohajda – CarboHyde CEO delivers a review on using cyclodextrins as active ingredients
  4. Julien Parcq & Damien TRUFFIN – from Roquette, our key partner in cyclodextrin education, discussing critical attributes of CD manufacturing & safety
  5. Milo Malanga PhD – CarboHyde CSO sharing from synthetic challenges
  6. Juan Manuel Benito – Bicyclos HEurope partner, expert in using CDs for gene delivery
  7. Caitriona O’DriscollGENEGUT coordinator, an expert in using CDs for gene delivery
  8. Francesco Trotta & Adrián Matencio Durán, our research partners on nanosponges from University of Turin
  9. Szabolcs Béni – from CarboHyde advisory board and BiCyclos member from Eötvös Loránd University, an expert on CD NMR and analysis
  10. Ilse Manet – BiCyclos coordinator, an expert in CD analysis and applications

And this is just the tip of the iceberg.

21st International Cyclodextrin Symposium, Carbohyde