Cyclodextrin derivatives for the treatment of gout and hyperuricemia

Inspiring research and patent from our collaborators at Università degli Studi di Torino and Universidad de Murcia

Adrián Matencio Durán, Francesco Trotta, Yousef Khazaei Monfared, Fabrizio Caldera, and José Manuel López Nicolás disclosed an invention in which various cyclodextrins are investigated in the therapy of gout and hyperuricemia.

WO2024133757 CYCLODEXTRIN DERIVATIVES FOR THE TREATMENT OF GOUT AND HYPERURICEMIA (wipo.int)

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers

Fresh from the oven, is a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.

Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.

Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers | ACS Medicinal Chemistry Letters

Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers

Fresh from the oven, a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.

Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.

Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.

Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers | ACS Medicinal Chemistry Letters

Giving you my heart becomes reality

Insight Heart is a 3D interactive app that offers a comprehensive and immersive journey into the human heart. It features high-resolution visuals, real-time insights, and interactive elements, making medical education engaging, accessible and enjoyable for students, physicians, and patients anytime and anywhere.

Its key features include a spatial computing experience, multi-user sessions, filter system exploration, and condition visualizations, which allow for remote and efficient collaboration, in-depth understanding of the heart’s complex structures, and an immersive experience of heart conditions.

This provides a new level of understanding and immersion in medical education.

INSIGHT HEART on Apple Vision Pro (youtube.com)

Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy

Its our pleasure to announce our most recent paper on

Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy

resulting from a collaboration with Semmelweis University and Aalborg University.

Recognizing that the distribution of substituents significantly influences the complexation ability and overall activity of the derivative, primarily by altering cavity dimensions, we present a straightforward and non-destructive method based on liquid state NMR spectroscopy to analyze the positions of the hydroxypropyl sidechains. This method relies on a single set of routine experiments to establish quantitative assignment and it provides a simple yet effective tool to disclose the substitution pattern of this complex material, utilizing easily accessible (400 MHz NMR) instrumentation.

Szabolcs BéniEszter KalydiThorbjørn Terndrup NielsenReinhard WimmerMilo Malanga PhD

Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy – ScienceDirect

Recovery of precious and rare earth metals using cyclodextrin

Today’s cyclodextrin is a unique practical application by CYCLADEX INC that many of you may not know: the recovery of precious metals such as gold, silver, platinum, palladium, and rare earths from precious metal-bearing materials.

Cycladex has developed a series of technologies for the isolation of important metals, including gold, silver, and, its newest discovery, a process for lithium. The Technology has been scaled up in our demonstration plant in the US, and the results show significantly lower costs with environmentally friendly chemicals and excellent yields.

In this setup, cyclodextrins are added to the alkali metal/metal bromide solution to precipitate a metal cyclodextrin complex.

Espacenet – RECOVERY OF PRECIOUS AND RARE EARTH METALS USING CYCLODEXTRIN

Using cyclodextrins in the textile industry

today’s cyclodextrin:
I brought some applications from the textile industry. Interestingly, there are no real successful commercial examples (that I know of, at least) using CDs in the textile industry. Yet there are so many inventions in the field, I am sure, this is just a matter of time. These two applications are both interesting, on is and ultraviolet-resistant application, the other is a flame-retardant material.

Flame-retardant non-woven fabric and preparation process

Anti-ultraviolet multifunctional textile fiber material and preparation method thereof

Live Q&A on Cyclodextrins

Breaking News: Live LinkedIn Q&A Session on Cyclodextrins Unveils Insights from Industry Experts!

Join us for an exclusive live event on LinkedIn as we delve into the fascinating world of cyclodextrins! This dynamic Q&A session brings together industry experts, researchers, and enthusiasts to explore the diverse applications and cutting-edge advancements in the field of cyclodextrin science.

📅 Date & Time: January 23, 2024 14.00 CET

📍 Location: LinkedIn Live – https://www.linkedin.com/events/7150478953097469953/?lipi=urn%3Ali%3Apage%3Ad_flagship3_company_admin%3BUXLAZXmBRdGB89QgeEFQdA%3D%3D

What to Expect:

  1. Insider Insights: Gain a deeper understanding of cyclodextrins and their versatile applications across various industries, from pharmaceuticals to food and beyond.
  2. Expert Panel: Engage with a panel of distinguished experts who will share their knowledge, experiences, and perspectives on the latest developments in cyclodextrin research.
  3. Interactive Q&A: Pose your burning questions directly to the experts during the live session. Get real-time answers and insights that matter to you.
  4. Networking Opportunities: Connect with like-minded professionals, researchers, and industry leaders who share a passion for cyclodextrin science.

How to Participate:

  • Follow our LinkedIn page to receive notifications and updates about the live event.
  • Set a reminder for the scheduled date and time to ensure you don’t miss out on this unique opportunity.
  • Prepare your questions in advance to make the most of the interactive Q&A session.

Who Should Attend:

  • Researchers and scientists in the fields of chemistry, pharmaceuticals, and materials science.
  • Professionals in industries utilizing cyclodextrins, including pharmaceuticals, food and beverages, cosmetics, and more.
  • Students and academics interested in gaining insights into the latest advancements in cyclodextrin research.

Don’t miss this chance to be part of a vibrant community discussing the groundbreaking advancements in cyclodextrin science! Mark your calendars and join us for an engaging and informative live Q&A session.

Stay tuned for more updates and surprises during the event! 🚀

If you follow us, you know that we are keen to spread the word about cyclodextrins and create educational content. Now, we would like to get closer to you and answer any questions you may have directly. Formulation, analysis, chemistry, business, future applications, everything is on the table.

Feel free to join and ask directly from our CEO, Tamas Sohajda.

You can register and learn more here: 

📍 Location: LinkedIn Live – https://www.linkedin.com/events/7150478953097469953/?lipi=urn%3Ali%3Apage%3Ad_flagship3_company_admin%3BUXLAZXmBRdGB89QgeEFQdA%3D%3D

Cyclodextrin supramolecular drug for targeted delivery of camptothecin as well as preparation method and application of cyclodextrin supramolecular drug

We believe that using cyclodextrin for targeted delivery of molecules is certainly one of the applications that will be in future’s research focus.

In this patent that we bring today as a good example, a camptothecin derivative and cyclodextrin polyrotaxane are subjected to a click chemical reaction under the catalysis of copper, and the cyclodextrin supramolecular drug for targeted delivery of camptothecin is obtained by using active folate termination. Cell experiments show that the compound has good targeting selectivity and anti-tumor effect, and also has the advantage of small toxic and side effects.

Espacenet – Cyclodextrin supramolecular drug for targeted delivery of camptothecin as well as preparation method and application of cyclodextrin supramolecular drug