How does one dissolve a brick in a beaker of water?
This is a question that James Pipkin, vice president of new product development at Ligand Pharmaceuticals and The University of Kansas answers in this interview.
Today’s cyclodextrin is a great story, case-study and learning opportunity about the rise of one of the most important players in the cyclodextrin industry.
Inspiring!
From Molecule to Market (lawrencebusinessmagazine.com)
Scientists create first mouse model with complete, functional human immunesystem and a human-like gutmicrobiome that is capable of mounting specific antibody responses.
Such a model would have unlimited uses in pharma development. The work of Paolo Casali et al groundbreaking and will disrupt the animal models we use for efficacy and safety studies. How would you use this model first? I imagine studies with vaccines probably…
Nature Immunology, 5 July 2024
Today’s cyclodextrin is about the intrinsic anti-inflammatory properties of CDs.
Inflammation is an essential contributor to the pathophysiology of numerous diseases, and dysregulation of the involved signaling cascades often culminates in uncontrollable disease progression and, ultimately, chronification. Effectively addressing these disorders is challenging due to their inherent complexity and the need to mitigate inflammation while preserving essential immune functions.
Amphihilic cyclodextrin-based nanoparticles exhibit significant downregulation of crucial pro-inflammatory markers, along with changes in inflammasome activation and the lipid profile of pro-inflammatory macrophages after CD nanoparticle application. The findings of this study underscore the potential of cyclodextrin-based nanoparticles as versatile biomaterials for treating the complex pathophysiology of various acute and chronic inflammation-associated disorders.
Anti–inflammatory effects of cyclodextrin nanoparticles enable macrophage repolarization and combat inflammation | Research Square
Felix E. B. Brettner, Annika Haessler, Jonas Schreiner et al from Goethe University Frankfurt
Inspiring research and patent from our collaborators at Università degli Studi di Torino and Universidad de Murcia
Adrián Matencio Durán, Francesco Trotta, Yousef Khazaei Monfared, Fabrizio Caldera, and José Manuel López Nicolás disclosed an invention in which various cyclodextrins are investigated in the therapy of gout and hyperuricemia.
WO2024133757 CYCLODEXTRIN DERIVATIVES FOR THE TREATMENT OF GOUT AND HYPERURICEMIA (wipo.int)
Fresh from the oven, is a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.
Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.
Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.
Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers | ACS Medicinal Chemistry Letters
Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.
Fresh from the oven, a paper from our long-term collaboration with Università di Catania and Salvo Sortino‘s team about Cyclodextrin Branched Polymer Nanocarriers.
Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest.
Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.
Hopefully, our CSO Milo Malanga will continue to promote such flourishing collaborations.
Insight Heart is a 3D interactive app that offers a comprehensive and immersive journey into the human heart. It features high-resolution visuals, real-time insights, and interactive elements, making medical education engaging, accessible and enjoyable for students, physicians, and patients anytime and anywhere.
Its key features include a spatial computing experience, multi-user sessions, filter system exploration, and condition visualizations, which allow for remote and efficient collaboration, in-depth understanding of the heart’s complex structures, and an immersive experience of heart conditions.
This provides a new level of understanding and immersion in medical education.
INSIGHT HEART on Apple Vision Pro (youtube.com)
Its our pleasure to announce our most recent paper on
Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy
resulting from a collaboration with Semmelweis University and Aalborg University.
Recognizing that the distribution of substituents significantly influences the complexation ability and overall activity of the derivative, primarily by altering cavity dimensions, we present a straightforward and non-destructive method based on liquid state NMR spectroscopy to analyze the positions of the hydroxypropyl sidechains. This method relies on a single set of routine experiments to establish quantitative assignment and it provides a simple yet effective tool to disclose the substitution pattern of this complex material, utilizing easily accessible (400 MHz NMR) instrumentation.
Szabolcs Béni, Eszter Kalydi, Thorbjørn Terndrup Nielsen, Reinhard Wimmer, Milo Malanga PhD
Today’s cyclodextrin is a unique practical application by CYCLADEX INC that many of you may not know: the recovery of precious metals such as gold, silver, platinum, palladium, and rare earths from precious metal-bearing materials.
Cycladex has developed a series of technologies for the isolation of important metals, including gold, silver, and, its newest discovery, a process for lithium. The Technology has been scaled up in our demonstration plant in the US, and the results show significantly lower costs with environmentally friendly chemicals and excellent yields.
In this setup, cyclodextrins are added to the alkali metal/metal bromide solution to precipitate a metal cyclodextrin complex.
Espacenet – RECOVERY OF PRECIOUS AND RARE EARTH METALS USING CYCLODEXTRIN
today’s cyclodextrin:
I brought some applications from the textile industry. Interestingly, there are no real successful commercial examples (that I know of, at least) using CDs in the textile industry. Yet there are so many inventions in the field, I am sure, this is just a matter of time. These two applications are both interesting, on is and ultraviolet-resistant application, the other is a flame-retardant material.
Flame-retardant non-woven fabric and preparation process
Anti-ultraviolet multifunctional textile fiber material and preparation method thereof
