Its our pleasure to announce our most recent paper on
Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy
resulting from a collaboration with Semmelweis University and Aalborg University.
Recognizing that the distribution of substituents significantly influences the complexation ability and overall activity of the derivative, primarily by altering cavity dimensions, we present a straightforward and non-destructive method based on liquid state NMR spectroscopy to analyze the positions of the hydroxypropyl sidechains. This method relies on a single set of routine experiments to establish quantitative assignment and it provides a simple yet effective tool to disclose the substitution pattern of this complex material, utilizing easily accessible (400 MHz NMR) instrumentation.
Szabolcs Béni, Eszter Kalydi, Thorbjørn Terndrup Nielsen, Reinhard Wimmer, Milo Malanga PhD
