toxicity - CarboHyde

Organophosphate-Cyclodextrin Inclusion Complex for Flame Retardancy in Doped Cellulose Acetate Butyrate Melt-Spun Fibers

Aug 2, 2023Tamas SohajdaToday's cyclodextrinflame retardant, toxicity

Today’s cyclodextrin:
Organophosphates are widely used flame retardants (FR) in everyday applications, and their leaching over time is a gaining concern. In this research, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide was chosen as a representative organophosphate FR to examine inclusion complex formation with γ-CD to enhance char formation as well as prevent the unnecessary release of toxic FR chemicals.

Yaewon Park, Debjyoti Banerjee, Soo Ah Jin, Ericka Ford et al.

Organophosphate-Cyclodextrin Inclusion Complex for Flame Retardancy in Doped Cellulose Acetate Butyrate Melt-Spun Fibers | Industrial & Engineering Chemistry Research (acs.org)

Transport Properties of Carbohydrates: Towards the Minimization Toxicological Risks of Cobalt and Chromium Ions

Jun 12, 2023Tamas Sohajdacarbohydratesdental health, toxicity

Cobalt and chromium are constituents of metal alloys for biomedical use, including dental prostheses. Thus, the release of these ions in the human body can lead to harmful biological effects.
The influence of oligosaccharides (α-, β-and γ-cyclodextrin), and a polysaccharide, sodium hyaluronate, on the diffusion of aqueous solutions of cobalt and chromium chlorides is presented by Ana Catarina Ribeiro et al. at Universidade de Coimbra.
It has been found that β-cyclodextrin has the highest interaction towards cobalt and chromium ions. This work will contribute to unveiling the mechanisms responsible for transport by diffusion in aqueous solutions and, therefore, mitigating the potential toxicity inherent to those metal ions.

See the full article on mdpi.com

Testing Serum Albumins and Cyclodextrins as Potential Binders of the Mycotoxin Metabolites Alternariol-3-Sulfate, Alternariol-9-Monomethylether and Alternariol-9-Monomethylether-3-Sulfate

Nov 22, 2022Tamas SohajdaToday's cyclodextrinfood&beverage, toxicity

Interesting study on mycotoxin binding CDs and serum albumin and their potential uses in food analysis delivered by the University of Pécs Medical School (POTE formerly) – and Cyclolab

Read the full article here

Inclusion Solves Insolubility —Translational Research Cycle from Bedside to Bench and Bench to Bedside for Drug Development Targeting Niemann-Pick Disease Type C

Oct 21, 2022Tamas Sohajdadrug developmentcholesterol, rare disease, toxicity, translational research

Tetsumi Irie form Kumamoto University explains the differences in the mechanisms of action for HPBCD and HPGCD in the treatment of Niemann-Pick C.

Full article: https://doi.org/10.1248/yakushi.21-00215

Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

Sep 16, 2022Tamas Sohajdadrug discoverytoxicity, toxicology

Yet another novel use proposed for sugammadex and SBE-cyclodextrin: as antidotes against chlorpromazine-induced acute toxicity. An excellent paper by Eszter Nyúl, Rita Klaudia Csepregi, Gábor Benkovics PhD, Lajos Szente, and Poór Miklós from the University of Pécs.

For more details, follow this link.