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  • Listen to the Carbohydrate Chronicles Podcast!
    • Carbohydrate Chronicles Season 1 / Episode 13 with László Somsák
    • Carbohydrate Chronicles Season 1 / Episode 12 with Barbara Richichi
    • Carbohydrate Chronicles Season 1 / Episode 11 with Matthew O’Connor
    • Carbohydrate Chronicles Season 1 / Episode 10 with Elham Blouet
    • Carbohydrate Chronicles Season 1 / Episode 9 with Erem Bilensoy
    • Carbohydrate Chronicles Season 1 / Episode 8 with Matthieu Sollogoub
    • Carbohydrate Chronicles Season 1 / Episode 7 with Luigi Lay
    • Carbohydrate Chronicles Season 1 / Episode 6 with Francesco Trotta
    • Carbohydrate Chronicles Season 1 / Episode 5 with Anne Imberty
    • Carbohydrate Chronicles Season 1 / Episode 4 with Milo Malanga
    • Carbohydrate Chronicles Season 1 / Episode 3 with José Manuel Garcia Fernandez
    • Carbohydrate Chronicles Season 1 / Episode 2 with Thorsteinn Loftsson
    • Carbohydrate Chronicles Season 1 / Episode 1 with Tony Molinaro

Synthesis, binding affinity, and inhibitory capacity of cyclodextrin-based multivalent glycan ligands for human galectin-3

Sep 28, 2022Tamas Sohajdacarbohydrates, drug discoveryanticancer, cancer research

Bathing in carbs: Lai-Xi Wang and his group from the University of Maryland reported the synthesis of cyclodextrin-based multivalent glycan ligands for human galectin-3. The GalNAc (Tn antigen) containing heptavalent ligand showed the highest affinity for human Gal-3 among the synthetic ligands tested, with an EC50 of 1.4 μM in binding to human Gal-3.

Link to the article

carbohyde, galectin, cyclodextrin


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