In Vitro Biological Properties of Cyclodextrin-Based Polymers: Interaction with Human Serum Albumin, Red Blood Cells and Bacteria

drug development, ,

Cyclodextrin polymers have increasing importance, as they are evaluated more and more frequenty in drug delivery solutions and non-pharma applications. This important paper deals with critical aspects of their behavior, such as interaction with human serum albumin, red blood cells bacteria.

Cyclodextrin derivatives and their polymers did not affect the secondary structure content of human serum albumin, which might mean a mild effect on the structural and functional properties of the main blood plasma protein.

Using the hemolysis test, it was found that polymers interact with red blood cells and can be assigned to non-hemolytic and slightly hemolytic groups as biocompatible materials, which are safe for in vivo use.

The cyclodextrins and their polymers did not extract proteins from bacterial cell walls and did not demonstrate any antibacterial activity against Gram-positive and Gram-negative strains.

Polysaccharides | Free Full-Text | In Vitro Biological Properties of Cyclodextrin-Based Polymers: Interaction with Human Serum Albumin, Red Blood Cells and Bacteria (mdpi.com)

Carbon quantum dots-containing poly(β-cyclodextrin) for simultaneous removal and detection of metal ions from water

carbohydrates

Moungi Bawendi, Louis Brus and Aleksey Yekimov were awarded the Nobel Prize in Chemistry 2023 for the discovery and development of quantum dots. These tiny particles have unique properties and now spread their light from television screens and LED lamps.
Did you know the QDs can also be combined with cyclodextrin? In this application, they are used for water purification, particularly to remove metal ions from water.
Great work by André Fajardo, Artur Valente & colleagues

Carbon quantum dots-containing poly(β-cyclodextrin) for simultaneous removal and detection of metal ions from water – ScienceDirect

The protective effect of cyclodextrin on color quality and stability of Cabernet Sauvignon red wine

Today's cyclodextrin,

today’s cyclodextrin: Weekend is almost here, so its time to enjoy some wine – with CDs, of course!


From this paper, you can learn about the protective effect of post-fermentation addition of CDs on color stability of red wine from the viewpoints of color characteristics, copigmentation and phenolic profiles. The evolution of anthocyanin form and the content of monomeric anthocyanins revealed that β-CD is a superior favorable cofactor during wine aging, but for the long-term aging, 2-HP-β-CD and 2-HP-γ-CD are more beneficial in promoting the formation of polymerized anthocyanins and the color stability. 

The protective effect of cyclodextrin on color quality and stability of Cabernet Sauvignon red wine1 – ScienceDirect

Welcome on board!

news

We are thrilled to share that our team has grown with two bright talents.

Daniel Bisericaru joined us after a few months of internship (through Università degli Studi di Torino) in the chemistry lab, has experience in the field of chemistry, synthesis and characterization of cyclodextrins and CD-based nanosponge complexes for drug delivery. Dani is a a Red Cross Volunteer, interested in the gym and applying science in it, loves travelling, food and manga.

Balázs Attila Kondoros is a formulation scientist with fresh PhD from University of Szeged in Pharmaceutical Sciences. Balázs has experience in designing and characterizing cyclodextrin formulations and interest in pharmaceutical technology. He enjoys swimming, playing video and board games.

Welcome guys, you make our team more colorful and more powerful!

Daniel Bisericaru
Balázs Attila Kondoros 

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

drug discovery,

Hungary is just a small grain on the beach of the pharma industry, yet from time to time we also make remarkable discoveries.
Today, its Motorpharma Ltd. a spin-off from Eötvös Loránd University that makes us proud by starting to dose their lead compounds MPH-220 to humans in Texas.
Mate Gyimesi, András Málnási-Csizmadia et al first published in 2020 in Cell about MPH-220, whish is targeting skeletal muscle myosin and can enabled muscle relaxation, in human and model systems, without cardiovascular side effects and improved spastic gait disorders after brain injury in a disease model. MPH-220 provides a potential nervous-system-independent option to treat spasticity and muscle stiffness.
Muscle spasticity after nervous system injuries and painful low back spasm affect more than 10% of global population. Current medications are of limited efficacy and cause neurological and cardiovascular side effects because they target upstream regulators of muscle contraction. Direct myosin inhibition could provide optimal muscle relaxation; however, targeting skeletal myosin is particularly challenging because of its similarity to the cardiac isoform. 

About Motorpharma: https://motorpharma.com/

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness: Cell

Preparation and evaluation of β-cyclodextrin-based nanosponges loaded with Budesonide for pulmonary delivery

carbohydrates, drug delivery, drug development,

Creating effective drug delivery systems for pulmonary applications is fascinating challenge. Recently, we have reported on the progress Aquilon Pharma made using cyclodextrins to deliver different APIs, their lead compounds being budasonide.
In this paper Francesco Trotta‘s and Aliasgar Shahiwala‘s groups proposes an alternative solution using cyclodextrin nanosponges. In vitro and in vivo studies showed almost complete drug release and drug absorption from the lungs in the initial 2 h for pure BUD, which were sustained up to 12 h from BUD loaded into nanosponges.

Preparation and evaluation of βcyclodextrin-based nanosponges loaded with Budesonide for pulmonary delivery – ScienceDirect

Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor

Today's cyclodextrin

Today’s cyclodextrin is a reminder of a fascinating application of cyclodextrins, the project CRLX-101 by Ellipses Pharma. This is a unique technology proposing a conjugate of a cyclodextrin-containing polymer to camptothecin for anticancer therapy, particularly ovarian cancer.
CRLX101 (formerly IT-101) is a first-in-class nanopharmaceutical, currently in clinical development, which has been developed by covalently conjugating camptothecin (CPT) to a linear, cyclodextrin-polyethylene glycol (CD-PEG) co-polymer that self-assembles into nanoparticles. As a nanometer-scale drug carrier system, the cyclodextrin polymeric nanoparticle technology, referred to as “CDP”, has unique design features and capabilities. Specifically, CRLX101 preclinical and clinical data confirm that CDP can address not only solubility, formulation, toxicity, and pharmacokinetic challenges associated with administration of CPT, but more importantly, can impart unique biological properties that enhance CPT pharmacodynamics and efficacy.

Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor

M2pep-Modified Cyclodextrin-siRNA Nanoparticles Modulate the Immunosuppressive Tumor Microenvironment for Prostate Cancer Therapy

carbohydrates, drug development

The fantastic coordinator of GENEGUT, Caitriona O’Driscoll just published her latest paper on using cyclodextrin in siRNA delivery.
We are proud to be part of this story. Way to go, guys!

M2pep-Modified Cyclodextrin-siRNA Nanoparticles Modulate the Immunosuppressive Tumor Microenvironment for Prostate Cancer Therapy | Molecular Pharmaceutics (acs.org)

Veterinary cosmetics with cyclodextrin

Today's cyclodextrin,

today’s #cyclodextrin: from CD News by István Puskás

Veterinary cosmetics is an emerging field, at last, no longer untouched by the application of cyclodextrins. A dog shampoo formulated with HPBCD provides spicy orange scent for the fur:

Dog Shampoo – Pet Head Ditch The Dirt – Company Of Animals

If there is no time / room for a full wash, a HPBCD containing spray is also available:

Dog Deodorant Spray – Ditch The Dirt – Company Of Animals UK