Prostate-specific membrane antigen (PSMA) ligands comprising an amylase cleavable linker
Using sugars in a prodrug concept is a fascinating idea as these compounds can bring so much to the table like improve stability, PK, or help in targeting. In this patent from Heidelberg University oligosaccharide conjugated prostate-specific membrane antigens are described where the bonds are cleaved by amylase in the body.
![](https://www.carbohyde.com/wp-content/uploads/2022/11/image-9.png)