We have known for a long time (at least since our CSO Milo‘s paper “Back to the Future”: A New Look at Hydroxypropyl Beta-Cyclodextrins that the degree of substitution (DS) plays a critical role in cyclodextrin complexation. Now Qiang Fu’s team from Shenyang Pharmaceutical University shares further proof of this by comparing HPBCDs from different sources.

As pharmacopeias currently allow a very wide range of acceptable DS and different types of HPBCDs are available on the market (just compare Kleptose HP and Kleptose HPB from Roquette as an example), this is something certainly to investigate when developing new products.