Synthesis of an amphiphilic vancomycin aglycone derivative inspired by polymyxins: overcoming glycopeptide resistance in Gram-positive and Gram-negative bacteria in synergy with teicoplanin in vitro

A fascinating journey in the world of novel glycopeptide antibiotics with stops such as overcoming resistance in Gram-positive and Gram-negative bacteria and combined antiviral and antibiotic effects guided by  Anikó Borbás and her group at University of Debrecen supported by several international KOLs in the field (Ilona Bakai-Bereczki, Ferenc Fenyvesi, Pal Herczegh, Eszter Ostorhazi, Henrietta Papp, Batta Gyula, Ana Mitrović, Janko Kos, István Hajdu, Dávid Bajusz, György Keseru, et al)

See the corresponding articles on nature.com:

Synthesis of an amphiphilic vancomycin aglycone derivative inspired by polymyxins: overcoming glycopeptide resistance in Gram-positive and Gram-negative bacteria in synergy with teicoplanin in vitro

Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria