Screening of sugars and cyclodextrins as carriers in montelukast dry powder inhalers processed by spray freeze drying
This study aimed to develop a site targeting montelukast sodium (MTK) microparticles as a respiratory drug delivery system using the spray freeze-drying process. A range of sugars and cyclodextrins were screened as carriers in order to find compatible excipients for the preparation of dry powder inhalers.
Powders containing CDs mostly showed proper aerodynamic behavior, especially in formulations containing alfa-cyclodextrin (A-CD), beta-cyclodextrin (β-CD), and highly branched cyclic dextrin (HBCD). Overall, data indicated that the CDs were excellent excipients for use with MTK for respiratory drug delivery.