Cyclodextrins

Today's cyclodextrin,

today’s cyclodextrin:
if you wish to learn more about the role of CD’s in chiral analysis and enantioseparation, this recent book chapter is for you:
Chiral Separations and Stereochemical Elucidation – Cyclodextrins
This chapter focuses on CDs in separation sciences covering also fundamental aspects including chiral recognition mechanisms as well as the use of CDs in the major separation technologies including gas chromatography, thin-layer chromatography, high-performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis.
#analysis #analyticalchemistry
Gerhard Scriba, Dr. Mari-luiza Konjaria, Dr. Sulaiman Krait

See this book chapter here: Cyclodextrins

The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment

carbohydrates, ,

Changes in the glycosylation process appear early in carcinogenesis and evolve with the growth and spread of cancer. The correlation of the characteristic glycosylation signature with the tumor stage and the appropriate therapy choice is important in translational medicine. Oncologists also pay attention to extracellular vesicles as reservoirs of new cancer glycomarkers that can be potent for cancer diagnosis/prognosis. In this review, Karolina Grzesik, Marcelina Janik, Dorota Hoja-Łukowicz from Jagiellonian University collect glycomarkers used in oncology and show their new glycoforms of improved clinical relevance, summarize current knowledge on the biological functions of glycoepitopes in cancer-derived extracellular vesicles and their potential use in clinical practice. Is glycomics a future of cancer diagnosis? It may be but in combination with other omics analyses than alone.

See the full review here: The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment


Polysorbates versus Hydroxypropyl Beta-Cyclodextrin: Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies

Today's cyclodextrin, ,

today’s cyclodextrin from Roquette:
Polysorbates versus Hydroxypropyl Beta-Cyclodextrin: Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies.
When subjected to light stress, adalimumab, as a model mAb, formulated in the presence of HPβCD, shows a significant decrease in protein aggregation and superior monomer and total protein recovery compared to PS 80-containing formulations. HPβCD also reduces both agitation and thermal stress-induced protein aggregation and prevents subvisible particle formation compared to PS 80. 
Hailong Zhang, Shiqi Hong, Tao Peng, Kwan Hang LAM, Keat Theng Chow, Rajeev Gokhale et al

See the article here: Polysorbates versus Hydroxypropyl Beta-Cyclodextrin: Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies