Facile microwave-assisted synthesis of Dialdehyde−β−Cyclodextrin for evaluation of angiogenesis in wound healing
An exponential growth in chronic non-healing wounds worldwide has propelled the dire need for the design of effectual interventions. Of late, dialdehyde polysaccharides have blossomed as novel antimicrobial agents. Yet, such dialdehydes, accomplished by periodate oxidation, are mostly synthesized by the conventional strategy. Microwave-assisted synthesis, as of today, finds greater relevance than conventional methods as it is environmentally more benign. This research contribution focuses on the microwave-initiated rapid synthesis of dialdehyde−β−Cyclodextrin (DA−β−CD) for its efficient use in chronic wound healing. The antibacterial and antibiofilm activities of DA−β−CD were systematically assessed against Staphylococcus epidermidis. The hemocompatible and cytotoxicity were also evaluated. In vivo angiogenic potential was performed in chick embryo. The results suggested that the microwaved product was endowed with improved aqueous solubility and fared better in wound healing than the conventional product.
Debosmita Dash, Purnendu Parhi et al at Ravenshaw University and Odisha University of Technology and Research