Tamas Sohajda, member of our scientific board talked today about innovations in cyclodextrin-based drug delivery at the Royal Society of Chemistry in London at an event dedicated to Innovations in Encapsulation.
today’s cyclodextrin:
CDs are currently not widely applied in vaccines, yet they have vast potential as stabilizers in cryopreservation (see Janssen Inc.’s covid vaccine) as well as a vaccine adjuvant. So far, it is mainly HPBCD that has been used for these purposes. In this early stage clinical trial, Vaxxas uses sulfobutyl-BCD in their quadrivalent influenza vaccine to preserve antigen potency during coating and storage.
Angus Forster, Adam Wheatley, Jesse Bodle, et al.
See the clinical trial details here
Fascinating breaking application of cyclodextrin polymer proposed by Noemi Bognanni, Francesco Bellia and Graziella Vecchio from Università di Catania. Based on the features of cyclodextrins, they derivatized cross-linked cyclodextrin polymers with histidine or carcinine moieties and found that amylase enzymes do not hydrolyze cyclodextrin polymers. The new polymers can form copper(II) complexes and may act as nanochelators to counteract copper(II) dyshomeostasis-related diseases. Furthermore, the copper(II) complexes show superoxide dismutase activity, similar to free carcinine and histidine complexes. The antioxidant biological activity of the copper(II) complex formed in situ may protect cells from oxidative damage related to #copper dyshomeostasis.
Genzyme Europe B.V. proposes oligosaccharide-acid α-glucosidase (GAA) conjugates, such as avalglucosidase alfa, to trea late-onset Pompe disease
See the full patent on Espacenet
today’s cyclodextrin:
In this invention, BioNTech SE provides a method of producing a composition comprising RNA lipoplex particles. The main focus of the description is antitumoral therapy.
In the formulation itself, the aqueous colloidal suspension of liposomes is combined with an aqueous solution comprising RNA, thereby producing the composition comprising RNA lipoplex particles. The formulation requires frozen storage conditions; hence the use of cyroprotectant is necessary. The invention proposes mono- di- and oligosaccharides to protect such compositions, including various cyclodextrins and cyclodextrin polymers.
The use of cyclodextrins as cryoprotectants and stabilizers in biopharmaceutical formulations is an emerging technology.
Dr. Hossam Hefesha, Heinrich Haas, Ferdia Bates, Christian Hotz
Katalin Karikó
See the full patent Patentscope
Antibody-drug conjugates with chito-oligosaccharide solubility tags from Merck Group (Carl Deutsch, Hélène Crassier; Dr. Christoph Korpus,; Prof. Dr. Dipl-Ing. Jörg von Hagen; Ulrike Richter-Sander)
today’s cyclodextrin:
using CDs to solubilize and stabilize cannabinoids is very popular in the pharma and nutraceutical/food industries. The most recent paper I read on the topic is from Canntab Therapeutics, yet in the past 25 years, since the first paper from Pekka Jarho et al., we have seen cannabis seed oil stabilized by BCD, an herbal medicine pill for treating constipation, fructus cannabis pill for the treatment of constipation and bowel discomfort, tea for patients in gastric cancer, intestine-lubricating and bowel relaxing granules. Among foods, yogurt enriched with herbal excipients, such as cannabis seeds, and BCD as a health food is claimed useful for soothing nerves, reducing blood pressure and blood fat, dispelling wind-damp, cold, and heat, losing weight, resisting aging, and relaxing bowels. On the analogy of powdered alcohol (Palcohol) prepared by complexing alcoholic drinks with CD, powdered weed, the cyclodextrin-encapsulated cannabinoid is expected to get on the market.
In this discovery, BCD Bioscience provides compositions comprising oligosaccharides for modulating microbiota and their metabolic products and uses them as therapeutics for treating, preventing, or improving conditions associated with various health conditions, including gastrointestinal health, cardiovascular health, renal system health, central nervous system health, immune system health, and urogenital health.
today’s #cyclodextrin:
Enevate Corporation proposes additives for energy storage devices comprising cyclodextrin-based compounds. Cyclodextrin-based compounds may serve as additives to the electrode in the device. Cyclodextrin-based compounds have a reduction potential, enabling the formation of a characteristic solid electrolyte interphase (SEI) with dense and low impedance. Battery performance is significantly influenced by the SEI thickness and components, which are solely determined by the structure of the additives.
today’s #cyclodextrin:
oral hygiene is extremely important. This is how you can use CDs in different applications:
Mouthwash: How a mouthwash can help prevent viral infection or Antiviral effect of mouthwashes against SARS-COV-2: A systematic review
Toothpaste: EURECO™ HC P11 A complex of beta-cyclodextrin and PAP
Other dental products: Cyclodextrins in dental products
