Risperidone-cyclodextrin complex reservoir combined with hydrogel-forming microneedle array patches for enhanced transdermal delivery

Today's cyclodextrin

Today’s cyclodextrin is about one of favourite novel DDS: microneedles!

Hydrogel-forming microneedle array patches (HFMAPs) are microneedles that create microconduits upon insertion and swelling in the skin, potentially allowing prolonged drug delivery without generating sharps waste.

To enhance the aqueous solubility and successfully deliver risperidone hydroxypropyl-beta-cyclodextrin (HP-β-CD) and hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) were utilized and their performance was tested using phase solubility studies.

For a 1-day application, HFMAPs showed greater systemic exposure to RIS compared to intramuscular control and exposure was extended to 5 days.

In conclusion, HFMAPs could serve as an alternative for delivering RIS in a sustained manner, potentially improving the treatment of schizophrenia.
Risperidone-cyclodextrin complex reservoir combined with hydrogel-forming microneedle array patches for enhanced transdermal delivery – ScienceDirect

Great work from Queen’s University Belfast and Ryan Donnelly – Lalitkumar Vora, PhD teams.

Hydrogel composition for use in the treatment of articular disorders

carbohydrates, drug development,

Fascinating patent by Bernard Martel, Nicolas Blanchemain and colleagues presenting hydrogels on anionic cyclodextrin polymers and chitosan for use in the treatment of articular disorders. The hydrogel combines an analgesic action with a visco-supplementation (a lubricating effect).

WO2024023350 HYDROGEL COMPOSITION FOR USE IN THE TREATMENT OF ARTICULAR DISORDERS (wipo.int)

Polysaccharide-based nanogels for biomedical applications: A comprehensive review

carbohydrates, drug delivery,

The biomedical, biotech, and food industries all use polysaccharides as vital biomolecules with a variety of applications. Polysaccharides have great potential as biomaterials, and polysaccharide-based nanogels have attracted a lot of attention as carriers for different bioactive agents due to their unique versatile groups, specifically for site-directed or controlled delivery of the payload and, particularly because of their physicochemical properties, biodegradability, and biocompatibility. The 3D polymer network of NG produced by chemical crosslinking or physical self-assembly may be used to incorporate hydrophilic or hydrophobic molecules, including tiny drugs and proteins, genetic material patterns, and even ultrasmall nanoparticles. In this review, the chemistry of specific common polysaccharides and the various methods used to fabricate polysaccharide-based NG is discussed, with an emphasis on their use NG as drug delivery systems.

FOUAD DAMIRI, Dr.Satish Rojekar, Yahya Bachra, Rajender Varma, Dr. Swetha Andra, Satheesh kumar Balu, Dr. Chandrakantsing Pardeshi, Vijaysing Pardeshi, Hitendra Patel, Ana Cláudia Paiva-Santos, Mohammed Berrada, Mónica Cristina García

See the full article here