Cyclodextrin nanoparticles in targeted cancer theranostics

Today's cyclodextrin,

Today’s cyclodextrin:
Cyclodextrin nanoparticles in targeted cancer theranostics
The field of cancer nanotheranostics is rapidly evolving, with cyclodextrin (CD)-based nanoparticles emerging as a promising tool. CDs, serving as nanocarriers, have higher adaptability and demonstrate immense potential in delivering powerful anti-cancer drugs, leading to promising and specific therapeutic outcomes for combating various types of cancer. The unique characteristics of CDs, combined with innovative nanocomplex creation techniques such as encapsulation, enable the development of potential theranostic treatments. The review here focuses mainly on the different techniques administered for effective nanotheranostics applications of CD-associated complex compounds in the domain of cancer treatments. The experimentations on various loaded drugs and their complex conjugates with CDs prove effective in in vivo results. Various cancers can have potential nanotheranostics cures using CDs as nanoparticles along with a highly efficient process of nanocomplex development and a drug delivery system. In conclusion, nanotheranostics holds immense potential for targeted drug delivery and improved therapeutic outcomes, offering a promising avenue for revolutionizing cancer treatments through continuous research and innovative approaches.

Frontiers | Cyclodextrin nanoparticles in targeted cancer theranostics (frontiersin.org)

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

carbohydrates, drug delivery

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives
Drug delivery systems consisting of cyclodextrins (CyDs) have kept constant attention for good compatibility, negligible toxicity, and improved pharmacokinetics of drugs. The unique hollow structure has endowed a lot of functions, such as the inclusion of guest molecules, functional modification of active hydroxyl groups, and noncovalent interactions. Besides, the polyhydroxy structure has further extended the functions of CyDs by inter/intramolecular interactions and chemical modification. Furthermore, the versatile functions of the complex contribute to physicochemical characteristics alteration of the drugs, therapeutic talent, stimulus-responsive switch, self-assemble capability, and fiber formation. This review attempts to list the recent progress of CyDs and discuss their roles in the drug delivery system. Future perspectives of the construction of CyD-based drug delivery systems are also discussed at the end of this review, which may be the possible direction for the construction of more rational and cost-effective delivery vehicles.

See the full article here

Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery

drug delivery, Today's cyclodextrin, ,

Today’s cyclodextrin:
Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery
Although cyclodextrin-based renal-clearable nanocarriers have a high potential for clinical translation in targeted cancer therapy, their designs remain to be optimized for tumor retention. Here Seoul National University and Chungnam National University report on the design of renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery. The optimized cyclodextrin shows a high tumor accumulation and is used for the delivery of doxorubicin and ulixertinib. Higher tumor accumulation and tumor penetration facilitate tumor elimination. The improved antitumor efficacy is demonstrated in heterotopic and orthotopic colorectal cancer models.

See the full article here: Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery

Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

Today's cyclodextrin,

today’s #cyclodextrin:
are peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables the irreversible deactivation of a wide range of T-like phages. The compounds can be used directly inside the environment of the bioreactor, but they are also a safe additive to stocks of antibiotics and expression inducers (such as isopropyl β-d-1-thiogalactopyranoside, i.e., IPTG) that cannot be autoclaved and are a common source of phage infections.
EPFL (École polytechnique fédérale de Lausanne) – Paulo Jacob Silva, Laura Roset Julià, Carla Malinverni, Lixia Wei, Marcin Los, and Francesco Stellacci et al

See the full article here: Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections


Synergistic Antitumor Potency of a Self-Assembling Cyclodextrin Nanoplex for the Co-Delivery of 5-Fluorouracil and Interleukin-2 in the Treatment of Colorectal Cancer

drug delivery, , ,

We are proud to share Milo Malanga‘s most recent collaboration paper with Hacettepe University on creating nanoplexes via cationic cyclodextrin polymer, 5-Fluorouracil, and Interleukin-2 based on the opposite charge interaction of macromolecules without undergoing any structural changes or losing the biological activity of Interleukin-2. In the colorectal tumor-bearing animal model, survival rate, antitumor activity, metastasis, and immune response parameters were assessed using a cyclodextrin derivative, which was found to be safe based on the ALT/AST levels in healthy mice.

Histomorphometric analysis showed that the groups treated with the nanoplex formulation had significantly fewer initial tumors and lung foci when compared with the control. The dual drug-loaded nanoplex could be a promising drug delivery technique in the immunochemotherapy of colorectal cancer.

Safiye Akkın, Gamze Varan, Anıl Işık, Petek Korkusuz, Erem Bilensoy et al.

See the full article here

Photo-Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles

carbohydrates,

This an excellent paper on the green production of ultrasmall glyco gold nanoparticles by an innovative photo-induced microfluidic approach.

Università degli Studi di Milano – Patricia Perez Schmidt, Katiuscia pagano, Marta Penconi, Ruth Mateu Ferrando, Claudio Evangelisti, Luigi Lay, Laura Ragona, Marcello Marelli, Laura Polito

See the full article here.