Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections
are peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables the irreversible deactivation of a wide range of T-like phages. The compounds can be used directly inside the environment of the bioreactor, but they are also a safe additive to stocks of antibiotics and expression inducers (such as isopropyl β-d-1-thiogalactopyranoside, i.e., IPTG) that cannot be autoclaved and are a common source of phage infections.
EPFL (École polytechnique fédérale de Lausanne) – Paulo Jacob Silva, Laura Roset Julià, Carla Malinverni, Lixia Wei, Marcin Los, and Francesco Stellacci et al
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