stability - CarboHyde

Formulations with reduced degradation of polysorbate

Nov 28, 2022Tamas SohajdaToday's cyclodextrindrug delivery, formulation development, stability

Using CDs to formulate proteins, dominantly to prevent aggregation is more or less known; there are CDs marketed for such uses (Roquette – Kleptose Biopharma) still, no product is on the market.
This patent from Genentech (Brian Connolly; Lydia Hamburg; Emily Holz) proposes another feature: when using CDs with monoclonal antibodies, degradation of polysorbates is also reduced.

Stabilization of proteins with cyclodextrins

Nov 10, 2022Tamas Sohajdacarbohydrates, drug deliveryaggregation, formulation development, monoclonal antibodies, protein research, stability

Have you ever tried using cyclodextrin to prevent protein folding and to stabilize them with such safe excipients instead surface active agents? From the patent of Tamas Sohajda, our board member, you can learn more about this potential.

See the patent on Patentscope