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  • Listen to the Carbohydrate Chronicles Podcast!
    • - Carbohydrate Chronicles Season 1 / Episode 13 with László Somsák
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CarboHyde

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  • Home
  • About Us
  • Pipeline
  • Technology
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  • CarboHyde News
  • CarboHyde’s Blog
  • Listen to the Carbohydrate Chronicles Podcast!
    • Carbohydrate Chronicles Season 1 / Episode 13 with László Somsák
    • Carbohydrate Chronicles Season 1 / Episode 12 with Barbara Richichi
    • Carbohydrate Chronicles Season 1 / Episode 11 with Matthew O’Connor
    • Carbohydrate Chronicles Season 1 / Episode 10 with Elham Blouet
    • Carbohydrate Chronicles Season 1 / Episode 9 with Erem Bilensoy
    • Carbohydrate Chronicles Season 1 / Episode 8 with Matthieu Sollogoub
    • Carbohydrate Chronicles Season 1 / Episode 7 with Luigi Lay
    • Carbohydrate Chronicles Season 1 / Episode 6 with Francesco Trotta
    • Carbohydrate Chronicles Season 1 / Episode 5 with Anne Imberty
    • Carbohydrate Chronicles Season 1 / Episode 4 with Milo Malanga
    • Carbohydrate Chronicles Season 1 / Episode 3 with José Manuel Garcia Fernandez
    • Carbohydrate Chronicles Season 1 / Episode 2 with Thorsteinn Loftsson
    • Carbohydrate Chronicles Season 1 / Episode 1 with Tony Molinaro

Formulations with reduced degradation of polysorbate

Nov 28, 2022Tamas SohajdaToday's cyclodextrindrug delivery, formulation development, stability

Using CDs to formulate proteins, dominantly to prevent aggregation is more or less known; there are CDs marketed for such uses (Roquette – Kleptose Biopharma) still, no product is on the market.
This patent from Genentech (Brian Connolly; Lydia Hamburg; Emily Holz) proposes another feature: when using CDs with monoclonal antibodies, degradation of polysorbates is also reduced.

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