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  • Home
  • Cyclodextrin Masterclass VII – Cyclodextrin basics
  • About Us
  • Pipeline
  • CarboHyde’s Blog
  • News
  • Listen to the Carbohydrate Chronicles Podcast!
    • - Carbohydrate Chronicles Season 2 / Ep 1 Application beyond pharma
    • - Carbohydrate Chronicles Season 2 / Ep 2 Cyclodextrin in biologic formulation
    • - Carbohydrate Chronicles Season 2 / Ep 3 Safety and toxicity
    • - Carbohydrate Chronicles Season 2 / Ep 4 Cyclodextrin in food and nutraceuticals
    • - Carbohydrate Chronicles Season 2 / Ep 5 Cyclodextrins to improve sport performance
    • - Carbohydrate Chronicles Season 2 / Ep 6 Cyclodextrins in 3D printing
    • - Carbohydrate Chronicles Season 2 / Ep 7 Cyclodextrin complex in the making
CarboHyde
  • Home
  • Cyclodextrin Masterclass VII – Cyclodextrin basics
  • About Us
  • Pipeline
  • CarboHyde’s Blog
  • News
  • Listen to the Carbohydrate Chronicles Podcast!
    • Carbohydrate Chronicles Season 2 / Ep 1 Application beyond pharma
    • Carbohydrate Chronicles Season 2 / Ep 2 Cyclodextrin in biologic formulation
    • Carbohydrate Chronicles Season 2 / Ep 3 Safety and toxicity
    • Carbohydrate Chronicles Season 2 / Ep 4 Cyclodextrin in food and nutraceuticals
    • Carbohydrate Chronicles Season 2 / Ep 5 Cyclodextrins to improve sport performance
    • Carbohydrate Chronicles Season 2 / Ep 6 Cyclodextrins in 3D printing
    • Carbohydrate Chronicles Season 2 / Ep 7 Cyclodextrin complex in the making

Formulations with reduced degradation of polysorbate

Nov 28, 2022Tamas SohajdaToday's cyclodextrindrug delivery, formulation development, stability

Using CDs to formulate proteins, dominantly to prevent aggregation is more or less known; there are CDs marketed for such uses (Roquette – Kleptose Biopharma) still, no product is on the market.
This patent from Genentech (Brian Connolly; Lydia Hamburg; Emily Holz) proposes another feature: when using CDs with monoclonal antibodies, degradation of polysorbates is also reduced.

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