aggregation - CarboHyde

Method for Reduced Aggregate Formation in Downstream Processing of Bispecific Antigen-Binding Molecules

Mar 8, 2023Tamas SohajdaToday's cyclodextrinaggregation, antibody, monoclonal antibodies

This is a great example of using CDs in a downstream processing method to produce bispecific antigen-binding molecule. In Amgen‘s invention, β-CD is applied in the process either in a buffer applied in the filtration step or added to the filtration pool after the UF/DF filtration step to keep the product in a non-aggregated form.
Yan Wang; Nicholas Marchand; Robert Brake; Maria Perry; Ashish Sharma; Eugene Sun

See the full patent here.

Stabilization of proteins with cyclodextrins

Nov 10, 2022Tamas Sohajdacarbohydrates, drug deliveryaggregation, formulation development, monoclonal antibodies, protein research, stability

Have you ever tried using cyclodextrin to prevent protein folding and to stabilize them with such safe excipients instead surface active agents? From the patent of Tamas Sohajda, our board member, you can learn more about this potential.

See the patent on Patentscope