Method for Reduced Aggregate Formation in Downstream Processing of Bispecific Antigen-Binding Molecules

This is a great example of using CDs in a downstream processing method to produce bispecific antigen-binding molecule. In Amgen‘s invention, β-CD is applied in the process either in a buffer applied in the filtration step or added to the filtration pool after the UF/DF filtration step to keep the product in a non-aggregated form.
Yan WangNicholas MarchandRobert BrakeMaria PerryAshish SharmaEugene Sun

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