Evaluation of polyanionic cyclodextrins as high affinity binding scaffolds for fentanyl

Today's cyclodextrin,

Fascinating application shared by Lawrence Livermore National Laboratory – Edmond Lau et al. on the synthesis of new CDs possessing extended thioalkylcarboxyl or thioalkylhydroxyl moieties and assess their binding affinity towards fentanyl hydrochloride. The performance of these host molecules portends their utility as platforms for medical countermeasures for opioid exposure, as biosensors, and in other forensic science applications.

See the full article on nature.com.

Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors

carbohydrates

It is fascinating how similar concepts can be used for entirely different purposes in drug delivery: while we use amphiphilic cyclodextrin for packaging oligonucleotides in the GENEGUT project, Erem Bilensoy and her team at Hacettepe University created camptothecin-loaded nanoparticles to treat colon cancer. The overall findings indicated that the strategy of orally targeting anticancer drugs such as CPT with positively charged poly-β-CD-C6 nanoparticles to colon tumors for local and/or systemic efficacy is promising.

Dr. SEDAT ÜNAL (PharmD/PhD), Gamze Varan, Yeşim Aktaş

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T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles

Today's cyclodextrin

This is a fascinating drug delivery approach focusing on CD-based nanoparticles encapsulating the Toll-like receptor 7 and 8 agonist R848 to target glioblastoma, the most common and aggressive primary brain tumor type. Results show that intravenous monotherapy with CDNP-R848 induces regression of established syngeneic experimental glioma, resulting in increased survival rates compared with unloaded CDNP controls. Mechanistically, CDNP-R848 treatment reshapes the immunosuppressive tumor microenvironment and orchestrates tumor clearing by pro-inflammatory tumor-associated myeloid cells, independently of T cells and NK cells. CDNP-R848 induces tumor regression in experimental glioma by targeting blood-borne macrophages without requiring adaptive immunity
The research was published by Heidelberg University – Verena Turco, Michael Breckwoldt, Michael Platten et al.

See the full article here on nature.com.

Impacts of β-cyclodextrin bead polymer (BBP) treatment on the quality of red and white wines: Color, polyphenol content, and electronic tongue analysis

Egyéb kategória

This is a really creative study presented by the  University of Pécs – John-Lewis Zinia Zaukuu, PhD, Lajos Szente,, Miklós Poór, et al., who examined the effects of insoluble β-CD bead polymer (BBP) on the quality of red and white wines – evaluated the BBP-induced changes in the color, the total polyphenol content as well as in the trans-resveratrol and quercetin concentrations of wine samples. Furthermore, e-tongue analyses were also performed as a highly sensitive tool to examine the influence of BBP on the taste of wines.

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Targeting galectin-driven regulatory circuits in cancer and fibrosis

carbohydrates, drug discovery,

Comprehensive summary from Gabriel Rabinovich Karina V. Marino Alejandro Cagnoni Diego Croci Russo (University of Buenos Aires) on the array of galectin-targeted strategies, including small-molecule carbohydrate inhibitors, natural polysaccharides and their derivatives, peptides, peptidomimetics, and biological agents reviewing the results of clinical trials that aim to evaluate the efficacy of galectin inhibitors in patients with idiopathic pulmonary fibrosis, nonalcoholic steatohepatitis, and cancer.

See the full article on nature.com.

Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin

drug delivery, ,

Check out the most recent paper of our collaborators in the GENEGUT Horizon Europe consortia presenting cyclodextrin-based nanoparticles for delivery of antisense oligonucleotides targeting huntingtin. Even if we were not part of this story, we are proud to get involved in the next chapter!

University College Cork – Monique Culturato Padilha Mendonça, PhD, Caitriona O’Driscoll et al
APC Microbiome Ireland – John Cryan

See the full article here