The cyclodextrin-enabled formulation of melphalan is an excellent example of how outdated excipients could be replaced with safer and more effective cyclodextrins to create patient-friendly and superior drug products!
Espacenet – Stable, liquid pharmaceutical compositions comprising melphalan
here you can find similar examples: Formulation development – www.carbohydesolutions.com
Today’s cyclodextrin is a new type of wound dressing developed at Cornell University by Tamer Uyar‘s team.
Bioactive compounds like lawsone offer dual benefits of wound healing and infection prevention, however, their limited solubility and viability hinder their applications. To address this, Hydroxypropyl-beta-cyclodextrin (HP-β-CD) and Hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) were employed.
Electrospinning yielded smooth and uniform nanofibers with an average diameter of ∼300–700 nm. The nanofibers exhibited ∼100 % loading efficiency of lawsone and its rapid release upon dissolution.
Notably, antibacterial assays demonstrated the complete elimination of Escherichia coli and Staphylococcus aureus colonies. The CD/lawsone nanofibers also showed suitable antioxidant activity ranging from 50% to 70%.
Today’s cyclodextrin is a nice collaborative formulation and in vivo (porcine) study between Semmelweis University and Cyclolab R&D Ltd.
In the project, the hemodynamic effect of inhalative SIN-1a (the unstable active metabolite of molsidomine, stabilized by cyclodextrine) was studied. The pulmonary vasodilator effect of SIN-1 was dose dependent, and in case of larger dose it was comparable to that of iNO. However, the vasodilatory effects of SIN-1 inhalation was not limited to the pulmonary circulation, a significant and dose-dependent systemic vasodilation could also be documented.
My only regret here is not all contributors met the authors’ list finally.
We have a nice read to propose for the week-started coffee, the most recent work of Szabolcs Béni from our advisory board and András Dohárszky, Fejős Ida, Eszter Kalydi and Gergely Völgyi.
A comprehensive investigation of the stability of cathinone derivatives and their cyclodextrin complexes.
Today’s cyclodextrin is highlighting a wonderful and important achievement from Aalborg University by Mads Koustrup Jørgensen and Thorbjørn Terndrup Nielsen, who are combining cyclodextrin chemistry and membrane technology in a new filtration project. They hope to present an effective and economically sustainable method for removing PFAS from our drinking water within a few years.
“In short, by rinsing a membrane in a specific alcohol solution of cyclodextrins, we can make the cyclodextrins bind to the membrane surface, making it functional for PFAS absorption without the need for complex chemistry,” says Mads Koustrup Jørgensen.
Learn more about the project here: Towards an efficient method for removing PFAS from water – Aalborg University (aau.dk)
today’s cyclodextrin:
is a fascinating and one-of-a-kind drug delivery vehicle. Nicole Steinmetz and Ivonne González-Gamboa created nanoparticles based on tobamovirus, to which they covalently attached beta-cyclodextrin that can non-covalently bind one or more active ingredients.
Such chemistry is not easy; you can learn more about it here: Custom synthesis of cyclodextrins – www.carbohydesolutions.com
METHODS AND COMPOSITIONS COMPRISING TOBACCO MILD GREEN MOSAIC VIRUS (TMGMV)
We have seen many applications for using cyclodextrin as active ingredients, yet diabetes has not been on the list yet.
Until now.
Alessia Fornoni and Merscher Sandra shared a concept for reducing lipid content in a cell or plasma membrane of a cell in a patient suffering from diabetes to redistribute or reduce cellular cholesterol accumulation.
US20230338412 METHOD OF USING CYCLODEXTRIN (wipo.int)
Today’s cyclodextrin:
Ready for some weekend workout? Have you planned to take some cyclodextrin afterward?
This study by Ismael Martínez Guardado and colleagues looks into the effect of taking 30 g cyclodextrin (Cluster Dextrin® – which is not clear to me what kind of cyclodextrin is, if any) during CrossFit Training on Performance and Fatigue. Although some differences were found, supplementation with 30 g of cyclodextrin did not have any metabolic or performance effects in CrossFit tests.
We are fond of developing advanced drug delivery solutions, including targeted precision systems. In this patent, you can find a great approach to such a process by combining cyclodextrin with Galnac for liver targeting.
Liver-targeted drug delivery carrier as well as preparation method and application
In the past few years, we have created dozens of educational materials on various uses of cyclodextrin, such as complex preparation, monoclonal antibody formulation, uses in vaccines, gene therapy, and various non-pharma applications.
We collected these decks for you in two easy-to-digest platforms.
Here you can find (and download) the decks: https://www.carbohydesolutions.com/natures-gift-for-mankind-are-cyclodextrins/
On our YouTube channel, you can watch them as short videos:
https://www.youtube.com/@CarboHyde
Learn and enjoy!