Tamas Sohajda - CarboHyde

Identification of a βCD-Based Hyper-Branched Negatively Charged Polymer as HSV-2 and RSV Inhibitor

Sep 21, 2022Tamas SohajdaEgyéb kategóriaantiviral, covid19, HIV, influenza

Cyclodextrin derivatives were demonstrated to be endowed with intrinsic antiviral action against several viruses (herpes, HIV, RSV, influenza, covid19, etc.). In this great work from Rachele Francese, Francesco Trotta, Claudio Cecone, Matteo Constantino, Gjylije Hoti, Pierangiola Bracco, and David Lembo from the University of Turin, four water-soluble hyper-branched beta cyclodextrin anionic polymer were screened against herpes simplex virus (HSV-2), respiratory syncytial virus (RSV), rotavirus (HRoV), and influenza virus (FluVA). The results suggest that the polymer virucidal activity against RSV can be exploited to produce new antiviral materials to counteract the virus dissemination through the air or direct contact.

Hydrogen sulfide and nitric oxide therapy for COVID-19 infection

Sep 20, 2022Tamas Sohajdadrug discoverycardiology, cardiovascular, covid19

This week seems to be all about cyclodextrin.
Chris Kevil’s group (Gopi Krishna Kolluru et al.) from Louisiana State University discovered the Sugammadex (among other prodrugs) could serve as an H2S donor and support the treatment of covid patients. Amazing work!

Lectin drug conjugates targeting high mannose N-glycans

Sep 19, 2022Tamas Sohajdacarbohydratesanticancer, cancer research

Great paper from The University of Kansas by Mark P. Farrell and their team on lectin drug conjugates targeting N-glycans.

Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

Sep 16, 2022Tamas Sohajdadrug discoverytoxicity, toxicology

Yet another novel use proposed for sugammadex and SBE-cyclodextrin: as antidotes against chlorpromazine-induced acute toxicity. An excellent paper by Eszter Nyúl, Rita Klaudia Csepregi, Gábor Benkovics PhD, Lajos Szente, and Poór Miklós from the University of Pécs.

For more details, follow this link.

The effect of alpha-cyclodextrin on post-prandial glucose excursions, a systematic meta-analysis

Sep 16, 2022Tamas SohajdaEgyéb kategóriablood glucose, diabetes, dietary supplement

An interesting idea proposed by Knut M. Wittkowski for the novel use of alpha-#cyclodextrin:
The effect of alpha-cyclodextrin on post-prandial glucose excursions, a systematic meta-analysis
For more details, click here

Methods for treatment of familiar heterozygous and homozygous hypercholesterolemia with cyclodextrins

Sep 16, 2022Tamas SohajdaEgyéb kategóriaatheroclerosis

Using cyclodextrins, especially 2-hydroxypropyl-beta-CD for the treatment of atherosclerosis has a hype, there are several companies and research groups chasing this holy grail. Fresh from the oven is the patent application from Beren Therapeutics explaining methods of treating familial hypercholesterolemia via different mechanisms of action.