Great cyclodextrin chemistry by Konstantin Lebedinskii and Jindřich Jindřich preparing a series of 6-monohalo (Cl, Br, and I) β-cyclodextrin derivatives with various types of methylations. This new method opens the way for preparing poorly investigated monofunctionalized selectively methylated cyclodextrins.
Today’s cyclodextrin:
is about the birth of these compounds. I collected two great sources; first, a review that presents a comprehensive view of CGTase produced by Bacillus spp. and other bacterial genera like Klebsiella, Paenibacillus, and Microbacterium. It also gives insight of the properties and recent biotechnological applications of cyclodextrins.
Cyclodextrin glucanotransferase: fundamentals and biotechnological implications | SpringerLink
However, the bioproduction of CDs still faces challenges in terms of optimization and process complexity. The 2nd study proposes a novel CD bioproduction system in a batch mode to increase yield and reduce costs. Scale-up to the bioreactor displayed improved growth kinetics for both bacteria and higher protein production and CGTase activity for Paenibacillus macerans.
Today’s cyclodextrin:
CO2 complexation with cyclodextrins by Mikael Bols‘ group:
Carbon dioxide emissions from industrial processes, power generation, and transportation contribute significantly to global warming and climate change. Carbon capture and storage (CCS) technologies are essential to reduce these emissions and mitigate the effects of climate change. Cyclodextrins (CDs), cyclic oligosaccharides, are studied as potential CO2 capture agents due to their unique molecular structures and high selectivity towards CO2. In this paper the binding efficiency of a number of cyclodextrins towards CO2 is investigated. It is found that the crystal structure of α-cyclodextrin with CO2 has a 1:1 stoichioimetry and that a number of simple and modified cyclodextrins bind CO2 in water with a Kg of 0.18–1.2 bar−1 (7–35 M−1) with per-O-methyl α-cyclodextrin having the highest CO2 affinity.
BJOC – CO2 complexation with cyclodextrins (beilstein-journals.org)
Excellent case study by The University of Texas at Austin on improving the bioavailabilty of Galeterone, a novel prostate cancer candidate treatment. KinetiSol(R) compounding was utilized to create galeterone amorphous solid dispersions containing the complexing agent hydroxypropyl-β-cyclodextrin or hypromellose acetate succinate with lower drug loads that both achieved a ~ 6 × increase in dissolution performance versus the 50–50 spray-dried dispersion. When compared to a spray-dried dispersion with an equivalent drug load, the KinetiSol amorphous solid dispersions formulations exhibited ~ 2 × exposure in an in vivo rat study.
Urvi Gala, Daniel Davis, Sandra Kucera, Dave A. Miller, & Robert Williams
Today’s cyclodextrin:
Organophosphates are widely used flame retardants (FR) in everyday applications, and their leaching over time is a gaining concern. In this research, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide was chosen as a representative organophosphate FR to examine inclusion complex formation with γ-CD to enhance char formation as well as prevent the unnecessary release of toxic FR chemicals.
Yaewon Park, Debjyoti Banerjee, Soo Ah Jin, Ericka Ford et al.
We are hearing a lot about how the cholesterol complexation ability of certain cyclodextrins, especially hydroxypropyl-beta-CD can be used to treat various diseases, like Alzheimer’s, Niemann Pick type C, atherosclerosis, familial hypercholesterolemia and many more.
But can this be a double-edged sword? This fascinating research suggests that High-Cholesterol Diet in Combination With Hydroxypropylβ-Cyclodextrin Induces NASH-Like Disorders in the Liver of Rats
You can read the full article here!
