If you even used CDs, you probably are familiar with SBECD. In this review, there is a nice colleaction of this parenteral excipient’s current and potential future applications.
Rucha Kothawade, Ashwini Markad, Sagar Pardeshi, Prashant Chaudhari, Marcela Longhi, Namdev Dhas, Jitendra Naik, Mónica Cristina García, Dr. Chandrakantsing Pardeshi [Ph.D.]
Two birds with one stone:
This study of the Silesian University of Technology and the Polish Academy of Sciences is close to our hearts as we both deal with glycoconjugates and cyclodextrin. They show the delivery of 8-Hydroxyquinoline Glycoconjugates and Doxorubicin using ACD-based hydrogel for enhanced tumor treatment.
Monika D. Gabriela Pastuch Piotr Kurcok
Have you ever tried using cyclodextrin to prevent protein folding and to stabilize them with such safe excipients instead surface active agents? From the patent of Tamas Sohajda, our board member, you can learn more about this potential.
We have known for a long time (at least since our CSO Milo‘s paper “Back to the Future”: A New Look at Hydroxypropyl Beta-Cyclodextrins that the degree of substitution (DS) plays a critical role in cyclodextrin complexation. Now Qiang Fu’s team from Shenyang Pharmaceutical University shares further proof of this by comparing HPBCDs from different sources.
As pharmacopeias currently allow a very wide range of acceptable DS and different types of HPBCDs are available on the market (just compare Kleptose HP and Kleptose HPB from Roquette as an example), this is something certainly to investigate when developing new products.
Articles
https://www.sciencedirect.com/science/article/abs/pii/S0167732222016440?via%3Dihub
https://jpharmsci.org/article/S0022-3549(16)41410-3/fulltext
We truly believe in the potential cyclodextrin hold in drug delivery in traditional formulations and upcoming applications like protein and oligonucleotide delivery, controlled or targeted release, and nanotechnology. Of course, our research is closer to the latter applications.
In this review published by Universidade de Coimbra (Laura Ferreira, Joana Campos, Francisco Veiga Catarina Cardoso, and Ana Cláudia Paiva-Santos), parenteral applications and their potential a summarized very well.
Great educative read!
