Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity
Mannosylated glycans impair normal T-cell development.
Gabriel Rabinovich, Salomé S. Pinho et al. discovered stage-speciﬁc glycome compositions during T-cell development in human and murine thymocytes, as well as dynamic alterations. In conclusion, mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inﬂammation susceptibility.