Mannosylated glycans impair normal T-cell development.
Gabriel Rabinovich, Salomé S. Pinho et al. discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes, as well as dynamic alterations. In conclusion, mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility.
See the full article here on nature.com!
