CarboHyde Recognized as a Key Innovator by the European Commission’s Innovation Radar

news, Today's cyclodextrin, ,

Great recognition for the GENEGUT project and our cyclodextrin science was received recently:

“Dear EU-funded innovator(s),
We are writing to you as you are an official contact person for your organisation’s participation in the GENEGUT project funded by the European Commission under Horizon Europe.

We are delighted to inform you that one of the innovations developed in the project has been analysed by the European Commission’s Innovation Radar.

Details of this innovation, and how it was categorised by the analysis, are as follows:

Innovation Title: Scaling-up Environmentally-Friendly Processes for ad-hoc designed RNA-driven vehicles;

Market Maturity of the Innovation: Business Ready

Market Creation Potential of the innovation: Addresses needs of existing markets

In this analysis Innovation Radar also identified the following project partner(s) – including your organisation – in the project as a ‘Key Innovator’ in the development of this innovation:
CarboHyde ZARTKORUEN MUKODO RESZVENYTARSASAG

In the near future we will publish the above information about this innovation on the European Commission’s Innovation Radar platform.”

So stay tuned, as soon you can read more about our RNA delivery platform on the EU’s portal too.

Ooops, we did it again

Today's cyclodextrin,

This time our flourishing GENEGUT collaboration produced a great paper on the SAR investigations of cyclodextrins in gene delivery.

This topic is essential to understand how cyclodextrins actually work when encapsulating different oligos and what are the ideal structures for the nanoparticle formation loading and transfection.

Got your attention?

Huge admiration to our collaborators, Ayse Kont, PhD, Monique Mendonca, PhD, Andrew Lindsay, Michael Cronin, Mary Cahill and Caitriona O’Driscoll

And last but not least, our team members, Milo and Kristóf.

The impact of cyclodextrin architecture and charge for optimized nucleic acid delivery: A comparison of monomers, dimers, and polymers – ScienceDirect

Ooops, we did it again.

Today's cyclodextrin, ,

This time our flourishing GENEGUT collaboration produced a great paper on the SAR investigations of cyclodextrins in gene delivery.

This topic is essential to understand how cyclodextrins actually work when encapsulating different oligos and what are the ideal structures for the nanoparticle formation loading and transfection.

Got your attention?

Huge admiration to our collaborators, Ayse Kont, PhD, Monique Mendonca, PhD, Andrew Lindsay, Michael Cronin, Mary Cahill and Caitriona O’Driscoll

And last but not least, our team members, Milo and Kristóf.

Learn all here: The impact of cyclodextrin architecture and charge for optimized nucleic acid delivery: A comparison of monomers, dimers, and polymers – ScienceDirect

The impact of cyclodextrin architecture and charge for optimized nucleic acid delivery: A comparison of monomers, dimers, and polymers

Today's cyclodextrin, ,

Ooops, we did it again.

This time our flourishing GENEGUT collaboration produced a great paper on the SAR investigations of cyclodextrins in gene delivery.

This topic is essential to understand how cyclodextrins actually work when encapsulating different oligos and what are the ideal structures for the nanoparticle formation loading and transfection.

Got your attention?

Huge admiration to our collaborators, Ayse Kont, PhD, Monique Mendonca, PhD, Andrew Lindsay, Michael Cronin, Mary Cahill and Caitriona O’Driscoll

And last but not least, our team members, Milo and Kristóf.

The impact of cyclodextrin architecture and charge for optimized nucleic acid delivery: A comparison of monomers, dimers, and polymers – ScienceDirect

CarboHyde in Ireland!

news,

We are super lucky to have many amazing collaborations in Ireland.

The CarboHyde delegation (Balázs, Dani and Ibi as a special guest) first visits the head of the GENEGUT project, Caitriona O’Driscoll at University College Cork then learns from Mary McNamara at Technological University Dublin in the Bicyclos HEurope project.

All about fancy amphiphilic cyclodextrins and their use in drug delivery and cancer therapy.

At University College Cork, School of Pharmacy, where Daniel and Balázs delivered a seminar highlighting two key pillars of CarboHyde’s expertise.

Dani gave an insightful talk on synthetic chemistry of amino acid–cyclodextrin systems, showcasing the innovations driving the field forward.

Balazs followed with an excellent overview of marketed formulations and new opportunities for peptide, nucleotide, and other bioactive compound delivery.

Thanks to UCC for hosting and to the engaged audience for the thoughtful discussions!

Genegut
Ireland genegut
Genegut Ireland

GENEGUT meeting in Uppsala

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We are proud to be part of the GENEGUT consortium, which just had its 7th general assembly in Uppsala.

Our main goal is to develop a novel drug delivery system for oral gene therapy, targeting Crohn’s disease.

CarboHyde’s contribution is the synthesis of nanoparticle-forming cyclodextrin building blocks, that can efficiently encapsulate and transfect siRNA into endothelial cells.

GENEGUt, Uppsala

Dr. Milo Malanga on what are cyclodextrins?

education,

🔎 In this video, Milo Malanga from CarboHyde explains how cyclodextrins are being harnessed to support the safe and effective delivery of RNA-based therapies for Crohn’s disease within the GENEGUT project.

🔬 GENEGUT is developing a first-in-class oral RNA-based therapy to target intestinal inflammation at its source, and cyclodextrins are playing an essential role.

The RNA delivery will be enabled by a combination approach using novel Biomaterials, including patented amphiphilic cyclodextrins and amino polyesters, are designed to protect and carry RNA through the gastrointestinal tract by forming nanoparticles.

Structure-activity relationship of modified amphiphilic cationic cyclodextrins for enhanced siRNA delivery

Egyéb kategória, Today's cyclodextrin, ,

Today’s cyclodextrin was a little gift under CarboHyde’s and GENEGUT’s Christmas tree.

This study identified the structural modifications that enhance gene delivery activity of a range of cationic amphiphilic CDs, including both β- and γ-CD.

Each CDs incorporated a C12 lipid chain on the primary face of the CD. On the secondary rim, at positions C2 and C3, either primary or tertiary amine groups.

A comparative in vitro study was conducted to assess the gene silencing efficacy of these nanoparticles using the luciferase reporter gene in A549-luc cells.

Gene silencing levels for both β- and γ-CDs increased when modified with a primary amine compared to a tertiary amine group at position C2. Gene expression inhibition was further improved when the CDs were functionalized with amine functionalities at positions C2 and C3.

Modification of the secondary side of γ-cyclodextrins with two sets of primary amine functionalities via a thiopropyl linker, as compared to a triazole linker, achieved up to 80% gene knockdown, regardless of dose.

Ayse Kont, Monique Mendonça, PhD, Milo Malanga PhD, Kristóf Felegyi, Andrew Lindsay, Michael Cronin, Mary Cahill, Caitriona O’Driscoll

Structure-activity relationship of modified amphiphilic cationic cyclodextrins for enhanced siRNA delivery – ScienceDirect

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Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin

drug delivery, ,

Check out the most recent paper of our collaborators in the GENEGUT Horizon Europe consortia presenting cyclodextrin-based nanoparticles for delivery of antisense oligonucleotides targeting huntingtin. Even if we were not part of this story, we are proud to get involved in the next chapter!

University College Cork – Monique Culturato Padilha Mendonça, PhD, Caitriona O’Driscoll et al
APC Microbiome Ireland – John Cryan

See the full article here